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URL: https://web.expasy.org/cellosaurus/CVCL_0019
Proper Citation: RRID:CVCL_0019
Description: Cell line SH-SY5Y is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Female
Disease: Neuroblastoma
Defining Citation: PMID:1354203, PMID:2535691, PMID:2846152, PMID:3968181, PMID:4748425, PMID:6137586, PMID:7687927, PMID:10630978, PMID:11668190, PMID:12505268, PMID:14676279, PMID:15150091, PMID:15720811, PMID:16120276, PMID:16822308, PMID:16957166, PMID:17506115, PMID:18957096, PMID:20655465, PMID:22213050, PMID:22460905, PMID:23421552, PMID:24466371, PMID:25182563, PMID:25730103, PMID:25884760, PMID:26342562, PMID:26972028, PMID:27141528, PMID:28118852, PMID:28350380, PMID:28601559, PMID:29468137, PMID:30894373, PMID:31068700, PMID:35893584
Comments: Virology: Low susceptibility to infection by Zika virus (ZIKV) (PubMed=29468137)., Characteristics: Particularly suitable for research in neurodegenerative diseases due to the fact that it has a specific uptake of norepinephrine (NA), expresses bona fide neurofilament proteins, and shows activity of enzymes involved in catecholaminergic systems (tyrosine and dopamine-beta-hydroxylases) (PubMed=35893584)., Characteristics: There seem to be differences in the retinoic acid (RA)-induced neuronal phenotype of SH-SY5Y cells from ATCC and ECACC. After 5 days of RA treatment, ECACC cells are slightly larger in size and contains significant amount of neuroblastic (N-type) cells and a small fraction of epithelial (S-type) cells (PubMed=18957096)., Characteristics: Neuroblastic type (N-type) (PubMed=15720811)., Population: Caucasian., From: Memorial Sloan Kettering Cancer Center; New York; USA., Part of: Human Protein Atlas, Cell Atlas panel., Part of: ENCODE project common cell types; tier 3., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Partially contaminated. Some laboratories that are redistributing this cell line are in fact redistributing a contaminated cell line of mouse origin (PubMed=25182563)..
Category: Cancer cell line
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Partially Contaminated
Problematic cell line: Partially contaminated. Some laboratories that are redistributing this cell line are in fact redistributing a contaminated cell line of mouse origin (PubMed=25182563).
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 810.
Source: Cellosaurus
