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URL: http://sfld.rbvi.ucsf.edu/
Proper Citation: Structure-function linkage database (RRID:SCR_001375)
Description: A database of hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities. The SFLD classifies evolutionarily related enzymes according to shared chemical functions and maps these shared functions to conserved active site features. The classification is hierarchical, where broader levels encompass more distantly related proteins with fewer shared features. It thus serves as the analysis and archive site for superfamilies targeted by the Enzyme Function Initiative, and is developed by the Babbitt Laboratory in collaboration with the UCSF Resource for Biocomputing, Visualization, and Informatics. The resource also provides a collection of tools and data for investigating sequence-structure-function relationships and hypothesizing function.
Abbreviations: SFLD
Resource Type: data or information resource, analysis service resource, service resource, production service resource, database, data analysis service
Defining Citation: PMID:18428763, PMID:16489747
Keywords: software, enzyme, structure-function relationship, blast, reaction, superfamily, hidden markov model, sequence alignment, protein similarity network, sequence, structure, function
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