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URL: https://netbio.bgu.ac.il/labwebsite/software/responsenet/
Proper Citation: ResponseNet (RRID:SCR_003176)
Description: WebServer that identifies high-probability signaling and regulatory paths that connect input data sets. The input includes two weighted lists of condition-related proteins and genes, such as a set of disease-associated proteins and a set of differentially expressed disease genes, and a molecular interaction network (i.e., interactome). The output is a sparse, high-probability interactome sub-network connecting the two sets that is biased toward signaling pathways. This sub-network exposes additional proteins that are potentially involved in the studied condition and their likely modes of action. Computationally, it is formulated as a minimum-cost flow optimization problem that is solved using linear programming.
Abbreviations: ResponseNet
Resource Type: data analysis service, production service resource, service resource, analysis service resource
Defining Citation: PMID:23761447, PMID:21576238
Keywords: interactome, gene, protein, signaling pathway, signaling, regulatory, pathway, regulatory pathway, bio.tools
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