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URL: http://nd4bb-enable.eu/

Proper Citation: European Gram Negative AntiBacterial Engine (RRID:SCR_003859)

Description: Consortium working to advance the development of potential antibiotics against Gram-negative bacteria, such as Escherichia coli. The project creates and manages a drug discovery engine for testing and optimizing molecules that are still in the earlier stages of drug discovery but have the potential to become future drug candidates capable of treating resistant Gram-negative infections. The project will focus on the discovery and pre-clinical stages of drug development, as well as (potentially) phase 1 clinical trials. ENABLE will run several drug discovery programs in parallel and the consortium seeks external hit and lead programs to join, through a series of open calls during the project. Researchers who have interesting molecules will have the opportunity to collaborate with a diverse range of experts in microbiology, pharmacology and chemistry to help advance their molecule through the drug development process until it is an attractive candidate for clinical testing. Specifically, the project is working towards: # identifying three antibacterial lead molecules which, following extensive testing, have been identified as having promising antimicrobial activity; # identifying two antibacterial clinical candidate molecules # advancing at least one compound into preclinical and phase 1 clinical studies, i.e. early clinical safety testing in humans.

Abbreviations: ENABLE

Synonyms: European Gram Negative Antibacterial Engine (ENABLE), European Gram-negative Antibacterial Engine

Resource Type: portal, consortium, organization portal, data or information resource

Keywords: drug, drug discovery, drug candidate, molecule, antibiotic, antimicrobial resistance, drug development, tool development, basic research, clinical trial, pre-clinical, antimicrobial, antibacterial, gram-negative bacteria