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South Carolina Medical University Mass Spectrometry Core Facility (RRID:SCR_017959)Copy Citation Copied
URL: http://cores.musc.edu/Core/MS
Proper Citation: South Carolina Medical University Mass Spectrometry Core Facility (RRID:SCR_017959)
Description: Core provides expertise, services, education, and instrumentation to enhance biomedical research through LC-MS/MS-based proteomics. Services are offered for protein identification; characterization of post-translational modifications; and quantitative proteomics to identify differentially expressed/degraded proteins, regulated sites of post-translational modification, protein-protein interactions, and protein targets of drugs identified in phenotypic screens. Analyses include sample preparation, LC-MS/MS, database searching, generation of reports, and assistance with data interpretation. Faculty and staff assist with experimental design and development/optimization of customized methodology for analysis of post-translationally modified peptides (e.g. phosphorylation and O-GlcNAc modification, N- and O-linked glycosylation, Cys modifications including S-glutathionylation, and glycation of Lys and Arg). Quantitative approaches including metabolic labeling (SILAC), isobaric tagging (iTRAQ/TMT), and label free proteomics (LFQ) are performed on Orbitrap Elite or Orbitrap Fusion Lumos Mass Spectrometers. Developes methodology to identify alterations in post-translational modifications that impact signal transduction, transcription, translation, and response to therapeutics with goal of enabling investigators to discover molecular mechanisms underlying disease progression and therapeutic response.
Synonyms: MUSC Mass Spectrometry Facility
Resource Type: service resource, core facility, access service resource
Keywords: Mass, spectrometry, expertise, service, education, instrumentation, proteomics, protein, identification, characterization, post translational, modification, target, drug, identification, phenotypic, screen, analysis, disease, service, core, ABRF
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