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URL: http://www.bioconductor.org/packages/release/bioc/html/vsn.html
Proper Citation: vsn (RRID:SCR_001459)
Description: Software package that implements a method for normalizing microarray intensities, both between colours within array, and between arrays. The method uses a robust variant of the maximum-likelihood estimator for the stochastic model of microarray data described in the references. The model incorporates data calibration (a.k.a. normalization), a model for the dependence of the variance on the mean intensity, and a variance stabilizing data transformation. Differences between transformed intensities are analogous to normalized log-ratios. However, in contrast to the latter, their variance is independent of the mean, and they are usually more sensitive and specific in detecting differential transcription.
Abbreviations: vsn
Synonyms: vsn - Variance stabilization and calibration for microarray data
Resource Type: software resource
Keywords: microarray, preprocessing, bio.tools
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