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Adult to Adult Living Donor Liver Transplantation Cohort Study (RRID:SCR_001494)Copy Citation Copied
URL: http://www.nih-a2all.org/
Proper Citation: Adult to Adult Living Donor Liver Transplantation Cohort Study (RRID:SCR_001494)
Description: Study consisting of nine liver transplant centers with expertise in adult living-donor liver transplantation (LDLT) and a central data coordinating center to provide valuable information on the outcomes of adult to adult living donor liver transplantation (AALDLT) to aid decisions made by physicians, patients, and potential donors. The study will establish and maintain the infrastructure required to accrue and follow sufficient numbers of patients being considered for and undergoing AALDLT to provide generalizable data from adequately powered studies. The major aims of A2ALL are as follows: * Quantify the impact of choosing LDLT on the candidate for transplantation * Characterize the difference between LDLT and deceased donor liver transplant (DDLT) in terms of post-transplant outcomes, including patient and graft survival, surgical morbidity, and resource utilization on the recipient of a transplant * Determine the short- and long-term health and quality of life (QOL) impact of donation, including (a) morbidity after liver donation and (b) long-term health-related QOL of donors. * Standardize and assess the role of informed consent in affecting the decision to donate and satisfaction after living liver donation * Other aims include comparison of the severity of recurrence of hepatocellular carcinoma for DDLT versus LDLT, the systematic characterization of liver regeneration and function in donors and recipients, the evaluation of the differences in the immune response to LDLT versus DDLT, and the establishment of a robust data and sample repository on liver transplantation that may be used to study clinical and biological questions as new technologies and resources become available. Patients enrolled in the study will be followed and managed in a standardized fashion.
Abbreviations: A2ALL
Synonyms: A2ALL: The Adult to Adult Living Donor Liver Transplantation Cohort Study
Resource Type: data or information resource, research forum portal, portal, resource, topical portal, disease-related portal
Defining Citation: PMID:18976306, PMID:18756453, PMID:16135918
Keywords: transplant, liver, adult human, risk factor, surgery, outcome, quality of life, clinical
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