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URL: http://hembase.niddk.nih.gov/
Proper Citation: HemBase (RRID:SCR_002880)
Description: Database designed for web-based examination of the human erythroid transcriptome. The database is organized to provide a cytogenetic band position, a unique name as well as a concise annotation for each entry. Search queries may be performed by name, keyword or cytogenetic location. Search results are linked to primary sequence data and three major human genome browsers for access to information considered current at the time of each search. Hembase provides interested scientists and clinical hematologists with a genome-based approach toward the study of erythroid biology. Red blood cells in the circulation arise from hematopoietic stem cells that proliferate as erythroid progenitors and differentiate into erythroid precursor cells in response to the hormone erythropoietin. Messenger RNA was isolated from those cells and used to generate gene libraries. Sequencing several thousand expressed sequence tags (EST) from those libraries was then performed. Those EST and sequences encoding several hundred additional genes with known expression in erythroid cells are compiled here as a database of human erythroid gene activity. The database is organized and linked according to the location of these sequences within the human genome.
Synonyms: Hembase
Resource Type: database, resource, data or information resource
Defining Citation: PMID:14681483, PMID:10409428
Keywords: erythroid, erythroid cell, erythroblast, expressed sequenced tag, transcriptome, gene, erythropoiesis, cytogenetic location, hematology, genome, red blood cell, progenitor cell, precursor cell, chromosome
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NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
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