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URL: http://tiger.dbs.nus.edu.sg/AllerHunter
Proper Citation: AllerHunter: Cross-reactive Allergen Prediction Home (RRID:SCR_002950)
Description: A cross-reactive allergen prediction program built on a combination of Support Vector Machine (SVM) and pairwise sequence similarity. Cross-reactivity is based on similarity of proteins to allergens. However, not all proteins with similar sequence or structure to known allergens are cross-reactive allergens. AllerHunter aims to predict allergens and non-allergens with high sensitivity and specificity, without compromising efficiency at classification of proteins with similar sequence to known allergens. There are distinct differences between prediction of allergenicity and cross-reactivity of allergens. Allergenicity is the immunogenic potential of an allergen to induce IgE antibody production, whereas cross-reactivity is the potential of a substance to bind to IgE previously induced by a known allergen. It is difficult to predict allergenicity because causes of immunogenicity of allergens are still not completely clear. However it is possible to predict cross-reactivity since it implies similarity in IgE binding sites. Please provide protein sequence in fasta format.
Abbreviations: AllerHunter
Synonyms: AllerHunter: Cross-reactive Allergen Prediction Program
Resource Type: service resource, analysis service resource, production service resource, data analysis service
Defining Citation: PMID:19516900
Keywords: fasta, allergen, prediction program, support vector machine
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