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URL: http://www.imi-marcar.eu/
Proper Citation: MARCAR (RRID:SCR_003755)
Description: Consortium to identify early biological indicators (biomarkers) that can be used to predict the development of cancer, as an unintended and adverse response to a new drug. The use of these biomarkers that detect early carcinogenicity will hopefully accelerate drug development and increase patient safety. The project focuses on non-genotoxic carcinogenesis (NGC) specifically looking at the role of epigenetic effects that could be caused as unintended consequences of new drugs. Using a combination of molecular analysis technologies, the consortium combines expertise in the field of biomarkers, human and rodent cancer models, imaging, molecular profiling and bioinformatics. Participants will focus on liver tumors, the organ most affected by non-genotoxic carcinogenesis, during the preclinical safety evaluations of candidate-medicines. Their findings aim to facilitate tumor identification in other organs as well, in hopes of providing insights in the mechanisms of tumor growth. The main objectives of the consortium are to: * Identify early biomarkers for predicting which compounds have a potential for later cancer development * Improve the scientific basis for assessing carcinogenic potential of non-genotoxic (NGC) drugs * Identify the molecular response to NGC exposure that underpins development of early exposure biomarkers * Improve drug safety and the efficiency of drug development by advancing the development of alternative research methods
Abbreviations: MARCAR
Synonyms: MARCAR - towards novel biomarkers for cancer risk assessment, bioMARkers and molecular tumor classification for non-genotoxic CARcinogenesis
Resource Type: portal, consortium, organization portal, data or information resource
Keywords: biomarker, tumor classification, non genotoxic carcinogen, drug-induced tumor, safety, drug development, drug, consortium, carcinogen, adverse response, liver, mri, gene interaction, dna modification, drug exposure, gene expression, mutation, nuclear receptor, drug safety, biological process, gene, imaging, molecular profiling
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