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Proper Citation: EpiTarget (RRID:SCR_003771)
Description: A multidisciplinary project focused on the process leading to epilepsy, epileptogenesis, in adults. Their main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Their central premise and vision is that a combinatorial approach is necessary to identify appropriate biomarkers and develop effective antiepileptogenic therapeutics. The project will focus on: * identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE); * exploring multiple basic mechanisms of epileptogenesis and their mutual interactions; * and translating these findings towards the clinic by validating biomarkers in human samples accessible to the consortium.
Abbreviations: EPITARGET
Synonyms: EPITARGET - Targets and biomarkers for antiepileptogenesis
Resource Type: portal, data or information resource
Keywords: common data element, preclinical, target, biomarker, antiepileptogenesis, adult human, animal model, clinical
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