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Towards novel translational safety biomarkers for adverse drug toxicity (RRID:SCR_004006)Copy Citation Copied
Proper Citation: Towards novel translational safety biomarkers for adverse drug toxicity (RRID:SCR_004006)
Description: Consortium to develop novel in vitro predictive screening tools and in vivo translational models and biomarkers to improve adverse drug reaction (ADR) hazard identification. This project studies the metabolic effects of eight drugs (among which are paracetamol and diclofenac ) with known side effects in the liver. By looking into the mechanics on a level ranging from the molecule to the patient, the researchers in this project aim to find biomarkers and develop tools for the early prediction of side effects of drugs. One of the breakthroughs in the project is the discovery that a person''''s genetic profile appears to be one of the mechanics that have an influence on the resistance to adverse drug reactions. The ability to identify adverse effects in an early stage will prevent much discomfort in patients and economic loss. Several PhD theses have been written from this project.
Abbreviations: ADR Research,
Synonyms: ADR Safety Biomarkers, Adverse Drug Reaction Research
Resource Type: portal, consortium, organization portal, data or information resource
Keywords: biomarker, drug development, adverse drug reaction, in vitro, in vivo, screening tool, translational model, drug, liver, side effect, thesis, paracetamol, diclofenac, genetic profile, gene, safety
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