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URL: http://www.wikigenes.org/e/art/e/258.html
Proper Citation: International Genomics of Alzheimers Project (RRID:SCR_004029)
Description: Consortium to discover and map the genes that contribute to Alzheimer's disease and completely understand the role inheritance plays. To achieve this goal, they will work to identify all the genes that contribute to the risk of developing this disease. Investigators will have access to combined genetic data from a large number of Alzheimer's disease subjects and compare it to genetic data from an equally large number of elderly people who do not have Alzheimer's. In the initial phase of the work, more than 20,000 people with Alzheimer's and about 20,000 healthy elderly subjects will be compared. As the study progresses, 10,000 additional people with Alzheimer's and the same number of healthy elderly subjects will be added to the study. The subjects for these studies come from different Alzheimer research project locations across Europe, the UK, the US, and Canada. Data is available from their 2014 publication in Translational Psychiatry at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944635/ (http://www.ncbi.nlm.nih.gov/pubmed/24495969) Currently, there is no public access to the raw individual level genetic data because of privacy considerations. Researchers working with US cohorts deposit data in the database of genotypes and phenotypes (dbGaP), where it is available to all researchers who can show that they are able to guarantee the security of the data. After scanning the DNA of over 74,000 patients and controls from 15 countries, the IGAP consortium reported 11 new regions of the genome involved in late-onset Alzheimer's disease. IGAP published its results in Nature Genetics on October 27, http://www.ncbi.nlm.nih.gov/pubmed/24162737
Abbreviations: IGAP
Synonyms: International Genomics of Alzheimer's Project
Resource Type: data or information resource, organization portal, portal, data set, consortium
Keywords: gene, inheritance, late adult human, genome-wide association study, database, basic science, biomarker, dna, data sharing
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Cohorts for Heart and Aging Research in Genomic Epidemiology |
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University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA |
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University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA |
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