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URL: http://www.ncbi.nlm.nih.gov/tools/cobalt/cobalt.cgi?link_loc=BlastHomeAd
Proper Citation: COBALT: Constraint-based Multiple Alignment Tool (RRID:SCR_004152)
Description: COBALT is a multiple sequence alignment tool that finds a collection of pairwise constraints derived from conserved domain database, protein motif database, and sequence similarity, using RPS-BLAST, BLASTP, and PHI-BLAST. Pairwise constraints are then incorporated into a progressive multiple alignment. A Linux executable for COBALT, and CDD and PROSITE data used is available at ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/cobalt/ COBALT has reasonable runtime performance and alignment accuracy comparable to or exceeding that of other tools for a broad range of problems.
Synonyms: NCBI COBALT, NCBI Constraint-based Multiple Alignment Tool, Constraint-based Multiple Alignment Tool
Resource Type: computation service resource, software resource
Defining Citation: PMID:17332019
Keywords: gold standard
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