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URL: http://syndb.cbi.pku.edu.cn
Proper Citation: SynDB: Synapse DataBase (RRID:SCR_005918)
Description: SynDB is an online resource of proteins known or predicted to be related to the synapse or synaptic activity, and extensive information on the proteins'' functions, sequences, structures, expression, pathways, interactions, and disease associations. It is intended to be a repository of current knowledge and data as well as a starting point for future proteomics research in neurobiology. SynDB is the first focused database of the molecular biology of the synapse proteome. It contains the most comprehensive collection of proteins (13809 unique proteins spanning 1979 species and 104 protein domains, Aug 2006) that are known or predicted to be associated with synaptic activities. It integrates extensive information on protein functions, sequences, structures, expression, pathways, interactions, and disease associations. SynDB was generated using a combination of automated approaches, including keyword- and domain-based searches, and manual curation. It serves as a starting point for future neurobiology, neuropharmacology, and neuroinformatics research. Synapse ontology is a set of standard vocabulary which help to describe all synaptic gene products in a consistant way. As in common ontology, synapse ontolgy is composed of all the terms in a hierarchical structure, but specifically restricted to the function and structure annotation of synapse related gene products. Synapse ontology is a callaborative fruit of bioinformatists and neural biologists. Synapse ontolgy is aimed to describe all the synaptic molecules in terms of structure/biochemistry of synapse and physiology/function at synapse in a specied-independent manner. The controled vocabularies are hierarchically structured, so you can browser the related gene products in different levels: for example, you can find all the gene products of synaptic vesicle cycling or ion channels and receptors, or you can zoom in on all the gene products playing roles in the priming step of synaptic vesicle cycling.
Synonyms: SynDB
Resource Type: controlled vocabulary, data or information resource, database, ontology
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