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URL: http://refold.med.monash.edu.au
Proper Citation: REFOLD (RRID:SCR_007889)
Description: It contains entries for refolding protocols for a wide range of proteins. REFOLD provides a means of dissminating refolding protocols and techniques to the scientific community. A large number of recombinant proteins expressed in bacteria are insoluble and thus require renaturation. Identifying optimal conditions and methodology for refolding can be time consuming and often rate-limiting. To this end, REFOLD was designed to assist in the design and implementation of methodologies for the in vitro refolding of proteins. The database contains heavily annotated entries for the refolding of a wide range of proteins which can be searched via multiple parameters using either simple or advanced search functions. The database can also be browsed by categories such as structural class, family, or refolding method. The web interface allows a detailed, sortable, spreadsheet-like list of results allowing quick visualisation of search results. Each entry contains detailed information regarding the protein of interest, methods and conditions employed, as well as reference and links to the relevant journal publication. Effective use of hyperlinks in results pages also allows useful browsing of entries for other proteins sharing similar properties or methods. REFOLD also provides analysis of the database through graphical representation of the data. The available graphs show the breakdown of refolding records in the database according to different parameters, such as refolding method, protein constructs and various refolding conditions. REFOLD graphs can be found here.
Synonyms: REFOLD
Resource Type: data or information resource, database
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Source: SciCrunch Registry
