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URL: http://www.cmbn.no/ottersen/
Proper Citation: Laboratory of Molecular Neuroscience, University of Oslo (RRID:SCR_008097)
Description: A laboratory that investigates the molecular mechanisms involved in the development of acute and chronic neurodegenerative disease, with a focus on the role of glutamate excitotoxicity. It aims at unraveling the molecular basis for cell death and edema development in stroke, and explores the pathophysiology of Alzheimer's disease and temporal lobe epilepsy. The main objective of the LMN is to advance understanding of the role of glutamate, as a transmitter substance in the normal brain and as a mediator of excitotoxicity in pathological conditions such as stroke. To this end the LMN employs several vital and nonvital imaging techniques. Model systems includes organotypic slice cultures and transgenic animals. An important focus of the LMN is to explore the role of DNA damage and repair in the pathogenesis of neurodegenerative disease. LMN is also engaged in research on molecular mechanism underlying brain edema, epilepsy, and Alzheimer's disease.
Abbreviations: UiO LMN
Synonyms: University of Oslo LMN
Resource Type: topical portal, data or information resource, portal
Keywords: epilepsy, excitotoxicity, acute, alzheimer's disease, brain, brain edema, cell death, chronic, damage, dna, glutamate, imaging, model systems, molecular, molecular mechanism, neurodegenerative disease, neuroprotective, neuroscience, repair, stroke, transmitter
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