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Adenylate Uridylate-rich-Rich Element-Containing mRNA Database (RRID:SCR_013107)Copy Citation Copied
URL: http://brp.kfshrc.edu.sa/ARED
Proper Citation: Adenylate Uridylate-rich-Rich Element-Containing mRNA Database (RRID:SCR_013107)
Description:
Database that contains the complete entries of human ARE-containing full-length mRNAs.
ARED is further clustered into five groups depending on the number of motifs in the ARE stretch. Groups 1-4 contain five, four, three and two pentameric (AUUUA) repeats, respectively, while Group 5 contains only one repeat within the 13-bp pattern. Clustering was performed in such a way that, for example, Group 1 included not only exact five or more continuous ARE pentamers but also those with 10% ambiguity, so that a stretch of NUUUAUUUAUUUAUUUAUUUN would fall in this category. This process was verified by a phylogenic tree relationship using Clustal-W alignment of ARE stretches and their variations. As could be expected, this analysis showed that the lower the number of ARE motifs in a group, the higher the number of sequences that were included, and apparently the more functionally diverse the corresponding ARE-genes.
Abbreviations: ARED
Synonyms: Adenylate Uridylate-Rich Element-mRNA database
Resource Type: database, data or information resource
Keywords: adenylate uridylate-rich element-mrna, are-gene, mrna, rna sequence database
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