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Texas A and M University Health Institute of Biosciences and Technology Microphysiological Lead Optimization and Toxicity Screening Core Facility (RRID:SCR_023717)Copy Citation Copied
URL: https://ibt.tamu.edu/centers/translational-cancer-research/stephan-lab/mlots/index.html
Proper Citation: Texas A and M University Health Institute of Biosciences and Technology Microphysiological Lead Optimization and Toxicity Screening Core Facility (RRID:SCR_023717)
Description: Supports lead optimization programs and has established roster of medium throughput microphysiologic screening platforms including tissue- and tumor-on-a-chip platforms, organoid, and spheroid culture systems that will be used to evaluate efficacy and toxicity of new lead compounds and drug combinations.Provides resources to identify toxic liabilities in lead series molecules before entering pre-clinical or clinical testing. MLOTS can evaluate NME for cardiovascular, neuro, or liver toxicity relative to reference standards using in vitro screening platforms. Facility will potentially enhance the effectiveness of CPRITs drug discovery programs.
Abbreviations: MLOTS
Synonyms: Texas A&M Health Science Center TAMU-Microphysiological Lead Optimization and Toxicity Screening facility (MLOTS), TAMU-Microphysiological Lead Optimization and Toxicity Screening facility (MLOTS)
Resource Type: service resource, access service resource, core facility
Keywords: USEDit, ABRF, evaluate efficacy and toxicity of new lead compounds, drug discovery, drug combinations,
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