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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=202
Proper Citation: RRID:MMRRC_000202-MU
Description: Mus musculus with name B6.Cg-Sod2tm1Cje/Mmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cardiovascular, Cell Biology, Diabetes, Hematology, Metabolism, Models for Human Disease, Neurobiology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased hematocrit [MP:0000208]| enlarged heart [MP:0000274]| thin ventricular wall [MP:0000280]| abnormal liver physiology [MP:0000609]| tremors [MP:0000745]| abnormal skeletal muscle morphology [MP:0000759]| abnormal forebrain morphology [MP:0000783]| abnormal cerebral cortex morphology [MP:0000788]| abnormal frontal lobe morphology [MP:0000798]| abnormal hippocampus morphology [MP:0000807]| abnormal thalamus morphology [MP:0000832]| abnormal cerebellum morphology [MP:0000849]| abnormal trigeminal V mesencephalic nucleus morphology [MP:0000906]| abnormal trigeminal motor nucleus morphology [MP:0000911]| abnormal motor neuron morphology [MP:0000937]| decreased spinal cord size [MP:0000956]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| abnormal optic nerve morphology [MP:0001330]| ataxia [MP:0001393]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| impaired righting response [MP:0001523]| cardiac hypertrophy [MP:0001625]| postnatal growth retardation [MP:0001732]| increased tumor incidence [MP:0002020]| seizures [MP:0002064]| premature death [MP:0002083]| abnormal brain morphology [MP:0002152]| hyperoxia [MP:0002319]| abnormal blood gas level [MP:0002329]| increased circulating ketone body level [MP:0002575]| hepatic steatosis [MP:0002628]| spongiform encephalopathy [MP:0002654]| dilated heart left ventricle [MP:0002753]| dilated heart right ventricle [MP:0002754]| dilated cardiomyopathy [MP:0002795]| increased heart weight [MP:0002833]| fatigue [MP:0002899]| increased circulating alkaline phosphatase level [MP:0002968]| increased liver weight [MP:0002981]| abnormal blood pH regulation [MP:0003027]| acidosis [MP:0003031]| hypocapnia [MP:0003032]| abnormal skeletal muscle fiber morphology [MP:0003084]| cardiac fibrosis [MP:0003141]| calcinosis [MP:0003195]| neuron degeneration [MP:0003224]| oxidative stress [MP:0003674]| pallor [MP:0003717]| abnormal retinal photoreceptor layer morphology [MP:0003728]| increased hepatocyte apoptosis [MP:0003887]| hypotonia [MP:0004144]| decreased fetal size [MP:0004200]| decreased spinal cord ventral horn cell number [MP:0005113]| abnormal retinal pigment epithelium morphology [MP:0005201]| abnormal brainstem morphology [MP:0005277]| abnormal enzyme/coenzyme level [MP:0005319]| increased circulating aspartate transaminase level [MP:0005343]| axon degeneration [MP:0005405]| decreased circulating glucose level [MP:0005560]| increased blood urea nitrogen level [MP:0005565]| abnormal cell physiology [MP:0005621]| abnormal mitochondrial physiology [MP:0006036]| brain vacuoles [MP:0008025]| thin retinal inner nuclear layer [MP:0008511]| decreased neuron number [MP:0008948]| decreased skeletal muscle fiber size [MP:0009400]| abnormal blood homeostasis [MP:0009642]| abnormal urine homeostasis [MP:0009643]| aciduria [MP:0010028]| abnormal respiratory electron transport chain [MP:0010955]| abnormal aerobic respiration [MP:0010957]| abnormal tricarboxylic acid cycle [MP:0010958]| decreased body surface temperature [MP:0011015]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011089]| perinatal lethality [MP:0011109]| complete penetrance [MP:0012431]| lethality throughout fetal growth and development [MP:0012551]| incomplete penetrance [MP:0013404]| increased lymphoma incidence [MP:0020543]
Affected Gene: Sod2
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
