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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=435
Proper Citation: RRID:MMRRC_000435-UNC
Description: Mus musculus with name STOCK Ptf1atm1.1(cre)Cvw/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Diabetes, Endocrine Deficiency; Mutation Type: Targeted Mutation ; Collection: BCBC-Beta Cell Biology Consortium
Phenotype: jaundice [MP:0000611]| enlarged spleen [MP:0000691]| paralysis [MP:0000753]| abnormal cerebellar molecular layer [MP:0000889]| weight loss [MP:0001263]| distended abdomen [MP:0001270]| increased metastatic potential [MP:0001272]| decreased metastatic potential [MP:0001273]| abnormal eye development [MP:0001286]| abnormal retina morphology [MP:0001325]| ataxia [MP:0001393]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| abnormal motor coordination/balance [MP:0001516]| hepatic necrosis [MP:0001654]| abnormal pancreas morphology [MP:0001944]| increased tumor incidence [MP:0002020]| premature death [MP:0002083]| abnormal innervation [MP:0002184]| abnormal brain commissure morphology [MP:0002199]| abnormal inhibitory postsynaptic currents [MP:0002945]| increased retinal ganglion cell number [MP:0002983]| abnormal digestive system development [MP:0003119]| abnormal GABAergic neuron morphology [MP:0003245]| abnormal duodenum morphology [MP:0003271]| pancreas fibrosis [MP:0003334]| pancreas cysts [MP:0003336]| chronic pancreas inflammation [MP:0003341]| enlarged pancreas [MP:0003450]| abnormal nervous system morphology [MP:0003632]| absent pancreas [MP:0003655]| abnormal pancreas development [MP:0003934]| small pancreas [MP:0004247]| abnormal synaptic vesicle number [MP:0004792]| abnormal paired-pulse inhibition [MP:0004807]| abnormal thrombosis [MP:0005048]| increased susceptibility to injury [MP:0005165]| abnormal pancreatic islet morphology [MP:0005215]| abnormal amacrine cell morphology [MP:0005240]| abnormal retinal neuronal layer morphology [MP:0006069]| absent amacrine cells [MP:0006095]| absent horizontal cells [MP:0008107]| thick retinal ganglion layer [MP:0008508]| absent retinal inner plexiform layer [MP:0008514]| abnormal synaptic bouton morphology [MP:0008571]| abnormal Purkinje cell differentiation [MP:0008579]| increased pancreas weight [MP:0009108]| abnormal pancreatic duct morphology [MP:0009143]| dilated pancreatic duct [MP:0009144]| abnormal pancreatic acinar cell morphology [MP:0009146]| increased pancreatic ductal adenocarcinoma incidence [MP:0009151]| increased pancreatic intraepithelial neoplasia incidence [MP:0009152]| increased pancreas tumor incidence [MP:0009153]| absent pancreatic acini [MP:0009156]| dilated gallbladder [MP:0009343]| abnormal hepatic portal vein morphology [MP:0010668]| neonatal lethality [MP:0011087]| complete penetrance [MP:0011270]| decreased excitatory postsynaptic current amplitude [MP:0013184]| hemorrhagic ascites [MP:0013221]
Affected Gene: crePtf1a
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
