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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=11791
Proper Citation: RRID:MMRRC_011791-MU
Description: Mus musculus with name 129S4/SvJae-Cd80tm1Shr Cd86tm1Shr Ctla4tm1Shr/Mmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased cell proliferation [MP:0000352]| abnormal spleen morphology [MP:0000689]| decreased IgG level [MP:0001805]| brain inflammation [MP:0001847]| abnormal lymph node B cell domain morphology [MP:0002344]| abnormal T cell physiology [MP:0002444]| abnormal immunoglobulin level [MP:0002490]| increased IgM level [MP:0002494]| abnormal cytokine secretion [MP:0003009]| insulitis [MP:0004031]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased regulatory T cell number [MP:0004974]| decreased double-positive T cell number [MP:0005092]| decreased B cell proliferation [MP:0005093]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005623]| abnormal meninges morphology [MP:0006387]| abnormal T cell number [MP:0008495]| decreased IgG1 level [MP:0008496]| decreased IgG2a level [MP:0008502]| increased IgG3 level [MP:0008560]| increased tumor necrosis factor secretion [MP:0008566]| increased interferon-gamma secretion [MP:0008688]| decreased interleukin-2 secretion [MP:0009023]| paresis [MP:0000754]| hindlimb paralysis [MP:0000755]| demyelination [MP:0000921]| abnormal dorsal root ganglion morphology [MP:0000961]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| brain inflammation [MP:0001847]| muscular atrophy [MP:0002269]| abnormal nervous system morphology [MP:0003632]| increased autoantibody level [MP:0003725]| abnormal myelin sheath morphology [MP:0003871]| abnormal ventral spinal root morphology [MP:0003993]| abnormal dorsal spinal root morphology [MP:0003994]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased regulatory T cell number [MP:0004974]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| abnormal action potential [MP:0005402]| abnormal nerve conduction [MP:0005403]| absent spleen germinal center [MP:0008474]| increased tumor necrosis factor secretion [MP:0008560]| decreased tumor necrosis factor secretion [MP:0008561]| increased interferon-gamma secretion [MP:0008566]| decreased interleukin-12 secretion [MP:0008664]| decreased nerve conduction velocity [MP:0008814]| decreased grip strength [MP:0010053]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| autoimmune response [MP:0001844]| myocarditis [MP:0001856]| lung inflammation [MP:0001861]| vasculitis [MP:0001864]| pancreas inflammation [MP:0001869]| salivary gland inflammation [MP:0001870]| premature death [MP:0002083]| abnormal T cell differentiation [MP:0002145]| abnormal T cell physiology [MP:0002444]| joint inflammation [MP:0002933]| abnormal cytokine secretion [MP:0003009]| increased length of allograft survival [MP:0004751]| abnormal regulatory T cell physiology [MP:0004946]| abnormal CD8-positive [MP:0005010]| alpha beta T cell morphology [MP:0005015]| increased T cell number [MP:0005090]| increased double-negative T cell number [MP:0005092]| decreased double-positive T cell number [MP:0005095]| decreased T cell proliferation [MP:0005348]| increased T cell proliferation [MP:0005350]| increased susceptibility to autoimmune disorder [MP:0008037]| abnormal T cell morphology [MP:0008075]| decreased CD4-positive [MP:0008568]| alpha beta T cell number [MP:0008750]| abnormal interleukin secretion [MP:0008826]| abnormal interferon level [MP:0008828]
Affected Gene: |Cd80||Cd86||Ctla4
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
