Searching the RRID Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=17238
Proper Citation: RRID:MMRRC_017238-UNC
Description: Mus musculus with name C.Cg-Igk-Jtm2Mwg Igh-Jtm2(3H9-VDJ*)Mwg Prkdcscid/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection:
Phenotype: spleen hypoplasia [MP:0000694]| increased anti-double stranded DNA antibody level [MP:0004762]| decreased B cell number [MP:0005017]| abnormal marginal zone B cell morphology [MP:0008180]| increased marginal zone B cell number [MP:0008181]| abnormal B cell receptor editing [MP:0008766]| small ears [MP:0000018]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| decreased leukocyte cell number [MP:0000221]| absent pre-B cells [MP:0000238]| increased granulocyte number [MP:0000322]| decreased bone marrow cell number [MP:0000333]| broad head [MP:0000346]| short snout [MP:0000445]| abnormal intestinal epithelium morphology [MP:0000488]| small salivary gland [MP:0000618]| abnormal immune system morphology [MP:0000685]| small lymphoid organs [MP:0000687]| spleen hypoplasia [MP:0000694]| abnormal Peyer's patch morphology [MP:0000696]| abnormal thymus morphology [MP:0000703]| small thymus [MP:0000706]| absent lymphocyte [MP:0000726]| absent CD8-positive [MP:0000727]| alpha-beta T cells [MP:0000807]| abnormal hippocampus morphology [MP:0000849]| abnormal cerebellum morphology [MP:0001153]| small seminiferous tubules [MP:0001156]| abnormal spermatogenesis [MP:0001262]| decreased body weight [MP:0001265]| decreased body size [MP:0001380]| reduced male mating frequency [MP:0001385]| pup cannibalization [MP:0001405]| impaired coordination [MP:0001559]| hyperglycemia [MP:0001661]| extended life span [MP:0001764]| abnormal homeostasis [MP:0001800]| abnormal humoral immune response [MP:0001802]| arrested B cell differentiation [MP:0001805]| decreased IgG level [MP:0001825]| arrested T cell differentiation [MP:0001841]| decreased level of surface class I molecules [MP:0001870]| salivary gland inflammation [MP:0001873]| stomach inflammation [MP:0001921]| reduced fertility [MP:0001925]| male infertility [MP:0001926]| female infertility [MP:0002024]| increased T cell derived lymphoma incidence [MP:0002052]| decreased tumor incidence [MP:0002078]| abnormal glucose homeostasis [MP:0002083]| premature death [MP:0002145]| abnormal T cell differentiation [MP:0002152]| abnormal brain morphology [MP:0002217]| small lymph nodes [MP:0002223]| lymphoid hypoplasia [MP:0002339]| abnormal lymph node morphology [MP:0002344]| abnormal lymph node B cell domain morphology [MP:0002357]| abnormal spleen white pulp morphology [MP:0002367]| abnormal thymus lobule morphology [MP:0002396]| abnormal hematopoietic system morphology/development [MP:0002406]| increased susceptibility to infection [MP:0002408]| abnormal double-positive T cell morphology [MP:0002411]| decreased susceptibility to bacterial infection [MP:0002432]| abnormal CD4-positive [MP:0002441]| alpha beta T cell morphology [MP:0002460]| abnormal granulocyte morphology [MP:0002471]| decreased immunoglobulin level [MP:0002473]| abnormal complement pathway [MP:0002590]| impaired complement classical pathway [MP:0002591]| increased mean corpuscular volume [MP:0002687]| decreased mean corpuscular volume [MP:0002722]| oligozoospermia [MP:0002727]| abnormal immune system organ morphology [MP:0002773]| decreased circulating insulin level [MP:0002780]| decreased circulating luteinizing hormone level [MP:0002782]| decreased circulating testosterone level [MP:0002790]| abnormal testes secretion [MP:0002804]| decreased circulating follicle stimulating hormone level [MP:0002831]| abnormal motor learning [MP:0002841]| absent Peyer's patches [MP:0002875]| impaired skeletal muscle contractility [MP:0002879]| decreased erythrocyte cell number [MP:0003339]| increased cellular sensitivity to X-ray irradiation [MP:0003402]| decreased pancreatic beta cell number [MP:0003642]| decreased liver weight [MP:0003790]| absent seminal vesicle [MP:0003918]| absent CD4-positive [MP:0004077]| alpha beta T cells [MP:0004097]| decreased kidney weight [MP:0004503]| abnormal striatum morphology [MP:0004703]| abnormal cerebellar cortex morphology [MP:0004751]| decreased incidence of tumors by ionizing radiation induction [MP:0004803]| abnormal vertebral column morphology [MP:0004804]| increased length of allograft survival [MP:0004816]| increased susceptibility to autoimmune diabetes [MP:0004953]| decreased susceptibility to autoimmune diabetes [MP:0005010]| abnormal class switch recombination [MP:0005011]| decreased spleen weight [MP:0005016]| abnormal CD8-positive [MP:0005017]| alpha beta T cell morphology [MP:0005018]| increased eosinophil cell number [MP:0005042]| decreased lymphocyte cell number [MP:0005065]| decreased B cell number [MP:0005070]| decreased T cell number [MP:0005093]| abnormal level of surface class II molecules [MP:0005095]| abnormal neutrophil morphology [MP:0005215]| impaired natural killer cell mediated cytotoxicity [MP:0005270]| decreased B cell proliferation [MP:0005277]| decreased T cell proliferation [MP:0005416]| abnormal pancreatic islet morphology [MP:0005425]| abnormal zygomatic bone morphology [MP:0005559]| abnormal brainstem morphology [MP:0005630]| abnormal circulating protein level [MP:0005671]| increased macrophage cell number [MP:0005673]| increased circulating glucose level [MP:0006198]| increased lung weight [MP:0006380]| abnormal response to transplant [MP:0008044]| decreased susceptibility to graft versus host disease [MP:0008045]| enophthalmos [MP:0008070]| abnormal spermatid morphology [MP:0008071]| increased NK cell number [MP:0008075]| decreased NK cell number [MP:0008079]| absent T cells [MP:0008081]| absent B cells [MP:0008101]| decreased CD4-positive [MP:0008135]| alpha beta T cell number [MP:0008195]| decreased CD8-positive [MP:0008209]| alpha-beta T cell number [MP:0008211]| abnormal single-positive T cell number [MP:0008215]| lymph node hypoplasia [MP:0008470]| small Peyer's patches [MP:0008807]| abnormal professional antigen presenting cell morphology [MP:0008826]| decreased pre-B cell number [MP:0008838]| decreased mature B cell number [MP:0009305]| decreased immature B cell number [MP:0009332]| abnormal spleen B cell follicle morphology [MP:0009401]| increased liver iron level [MP:0009404]| abnormal splenic cell ratio [MP:0009412]| decreased transforming growth factor level [MP:0009419]| decreased retroperitoneal fat pad weight [MP:0009543]| abnormal splenocyte morphology [MP:0009697]| increased skeletal muscle fiber diameter [MP:0009856]| centrally nucleated skeletal muscle fibers [MP:0010179]| skeletal muscle fiber degeneration [MP:0010250]| skeletal muscle fibrosis [MP:0010766]| abnormal thymus corticomedullary boundary morphology [MP:0011473]| abnormal copulation [MP:0012106]| failure of ejaculation [MP:0014127]| rough coat [MP:0014130]
Affected Gene: |Igk-J||||Prkdc
Expand AllWe found {{ ctrl2.mentions.all_count }} mentions in open access literature.
We have not found any literature mentions for this resource.
We are searching literature mentions for this resource.
Most recent articles:
{{ mention._source.dc.creators[0].familyName }} {{ mention._source.dc.creators[0].initials }}, et al. ({{ mention._source.dc.publicationYear }}) {{ mention._source.dc.title }} {{ mention._source.dc.publishers[0].name }}, {{ mention._source.dc.publishers[0].volume }}({{ mention._source.dc.publishers[0].issue }}), {{ mention._source.dc.publishers[0].pagination }}. (PMID:{{ mention._id.replace('PMID:', '') }})
Check
for all resource mentions.
A list of researchers who have used the resource and an author search tool
A list of researchers who have used the resource and an author search tool. This is available for resources that have literature mentions.
No rating or validation information has been found for C.Cg-Igk-Jtm2Mwg Igh-Jtm2(3H9-VDJ*)Mwg Prkdcscid/Mmnc.
No alerts have been found for C.Cg-Igk-Jtm2Mwg Igh-Jtm2(3H9-VDJ*)Mwg Prkdcscid/Mmnc.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
