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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=30044
Proper Citation: RRID:MMRRC_030044-UNC
Description: Mus musculus with name STOCK Nkx2-1tm1Shk/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Endocrine Deficiency, Models for Human Disease, Neurobiology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal foregut morphology [MP:0000474]| abnormal forebrain morphology [MP:0000783]| abnormal diencephalon morphology [MP:0000830]| abnormal hypothalamus morphology [MP:0000837]| abnormal lung development [MP:0001176]| pulmonary hypoplasia [MP:0001178]| impaired coordination [MP:0001405]| abnormal bronchus morphology [MP:0002264]| abnormal type II pneumocyte morphology [MP:0002275]| abnormal trachea morphology [MP:0002282]| abnormal pulmonary circulation [MP:0002295]| abnormal testes secretion [MP:0002782]| abnormal Leydig cell morphology [MP:0002786]| small thyroid gland [MP:0002951]| abnormal tracheal cartilage morphology [MP:0003120]| tracheoesophageal fistula [MP:0003321]| abnormal thyroid gland development [MP:0003421]| decreased tracheal cartilage ring number [MP:0004551]| abnormal thoracic cavity morphology [MP:0004733]| decreased testis weight [MP:0004852]| increased circulating thyroid-stimulating hormone level [MP:0005122]| absent thyroid gland [MP:0005314]| absent pituitary gland [MP:0005315]| decreased lung weight [MP:0005631]| abnormal lung epithelium morphology [MP:0006382]| abnormal adrenal cortex morphology [MP:0008288]| decreased fetal weight [MP:0009431]| absent type II pneumocytes [MP:0010812]| absent alveolar lamellar bodies [MP:0010814]| abnormal lung saccule morphology [MP:0010825]| abnormal pulmonary alveolus epithelium morphology [MP:0010898]| abnormal pulmonary alveolar parenchyma morphology [MP:0010901]| abnormal bronchus epithelium morphology [MP:0010943]| decreased surfactant secretion [MP:0010993]| impaired branching involved in bronchus morphogenesis [MP:0011028]| postnatal lethality [MP:0011086]| incomplete penetrance [MP:0011087]| neonatal lethality [MP:0011143]| complete penetrance [MP:0012684]| thick lung-associated mesenchyme [MP:0013337]| abnormal pleural cavity morphology [MP:0013351]| abnormal adenohypophysis development [MP:0013352]| abnormal Rathke's pouch development [MP:0014198]| abnormal Rathke's pouch apoptosis [MP:0020556]| absent pituitary infundibular stalk [MP:0020558]
Affected Gene: Nkx2-1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
