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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=30638
Proper Citation: RRID:MMRRC_030638-UNC
Description: Mus musculus with name B6;129-Apobec1tm1Rub Ldlrtm1Her Apobtm1Mae/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Cardiovascular, Metabolism; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased circulating LDL cholesterol level [MP:0000183]| abnormal circulating HDL cholesterol level [MP:0000184]| abnormal triglyceride level [MP:0000187]| exencephaly [MP:0000914]| hydroencephaly [MP:0001891]| decreased circulating VLDL cholesterol level [MP:0005146]| decreased circulating cholesterol level [MP:0005179]| abnormal blood homeostasis [MP:0009642]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating LDL cholesterol level [MP:0000183]| decreased circulating HDL cholesterol level [MP:0000186]| increased circulating triglyceride level [MP:0001552]| increased circulating HDL cholesterol level [MP:0001556]| abnormal lipid homeostasis [MP:0002118]| increased circulating VLDL triglyceride level [MP:0003975]| decreased circulating cholesterol level [MP:0005179]| abnormal microglial cell morphology [MP:0000136]| abnormal circulating cholesterol level [MP:0000180]| abnormal circulating LDL cholesterol level [MP:0000181]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating LDL cholesterol level [MP:0000183]| decreased circulating HDL cholesterol level [MP:0000186]| abnormal triglyceride level [MP:0000187]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| hypertension [MP:0000231]| altered response to myocardial infarction [MP:0000343]| alopecia [MP:0000414]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| decreased corpus callosum size [MP:0000781]| abnormal hippocampus morphology [MP:0000807]| abnormal cerebellum morphology [MP:0000849]| abnormal Purkinje cell morphology [MP:0000877]| decreased Purkinje cell number [MP:0000880]| abnormal CNS glial cell morphology [MP:0000952]| scaly skin [MP:0001192]| thick skin [MP:0001200]| spontaneous skin ulceration [MP:0001209]| skin lesions [MP:0001212]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| decreased anxiety-related response [MP:0001364]| hyperactivity [MP:0001399]| abnormal response to new environment [MP:0001413]| abnormal spatial learning [MP:0001463]| abnormal cardiovascular system physiology [MP:0001544]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| abnormal circulating enzyme level [MP:0001570]| cardiac hypertrophy [MP:0001625]| skin edema [MP:0001786]| impaired macrophage phagocytosis [MP:0001798]| decreased IgG level [MP:0001805]| liver inflammation [MP:0001860]| abnormal glucose homeostasis [MP:0002078]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal brain morphology [MP:0002152]| abnormal astrocyte morphology [MP:0002182]| abnormal macrophage physiology [MP:0002451]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| heart left ventricle hypertrophy [MP:0002625]| hepatic steatosis [MP:0002628]| decreased circulating triglyceride level [MP:0002644]| decreased circulating corticosterone level [MP:0002665]| decreased circulating insulin level [MP:0002727]| abnormal aortic valve morphology [MP:0002747]| increased circulating alanine transaminase level [MP:0002941]| increased liver weight [MP:0002981]| decreased myocardial infarction size [MP:0003038]| altered response to CNS ischemic injury [MP:0003075]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal leukocyte migration [MP:0003156]| abnormal aorta elastic fiber morphology [MP:0003211]| amyloid beta deposits [MP:0003329]| liver fibrosis [MP:0003333]| increased cardiac output [MP:0003394]| abnormal response/metabolism to endogenous compounds [MP:0003638]| oxidative stress [MP:0003674]| abnormal microglial cell physiology [MP:0003691]| xanthoma [MP:0003692]| maternal effect [MP:0003718]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| abnormal feces composition [MP:0003868]| decreased macrophage cell number [MP:0003884]| increased hepatocyte apoptosis [MP:0003887]| abnormal ST segment [MP:0003897]| abnormal heart left ventricle morphology [MP:0003921]| abnormal cholesterol level [MP:0003947]| decreased lean body mass [MP:0003961]| increased circulating VLDL triglyceride level [MP:0003975]| decreased circulating VLDL triglyceride level [MP:0003976]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| abnormal arteriole morphology [MP:0004112]| abnormal bile secretion [MP:0004772]| skin inflammation [MP:0004947]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal thrombosis [MP:0005048]| decreased cardiac muscle contractility [MP:0005140]| abnormal circulating VLDL cholesterol level [MP:0005144]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| abnormal retinal pigment epithelium morphology [MP:0005201]| abnormal Bruch membrane morphology [MP:0005239]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| decreased triglyceride level [MP:0005318]| insulin resistance [MP:0005331]| abnormal fat pad morphology [MP:0005334]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal circulating protein level [MP:0005416]| abnormal food intake [MP:0005449]| increased susceptibility to weight gain [MP:0005455]| increased percent body fat/body weight [MP:0005458]| decreased percent body fat/body weight [MP:0005459]| abnormal eye electrophysiology [MP:0005551]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to diet-induced obesity [MP:0005659]| increased apoptosis [MP:0006042]| decreased cerebral infarction size [MP:0006058]| decreased susceptibility to ischemic brain injury [MP:0006059]| calcified aortic valve [MP:0006116]| aortic valve stenosis [MP:0006117]| artery occlusion [MP:0006134]| abnormal choriocapillaris morphology [MP:0006238]| aortic aneurysm [MP:0006278]| abnormal epididymal fat pad morphology [MP:0006319]| abnormal macrophage derived foam cell morphology [MP:0008243]| abnormal adrenal gland zona fasciculata morphology [MP:0008294]| abnormal spatial working memory [MP:0008428]| abnormal short term spatial reference memory [MP:0008431]| abnormal long term spatial reference memory [MP:0008432]| slow postnatal weight gain [MP:0008489]| increased circulating tumor necrosis factor level [MP:0008553]| decreased tumor necrosis factor secretion [MP:0008561]| decreased interferon-gamma secretion [MP:0008567]| abnormal interleukin secretion [MP:0008568]| abnormal synaptic bouton morphology [MP:0008571]| photoreceptor outer segment degeneration [MP:0008584]| increased circulating interleukin-10 level [MP:0008593]| decreased circulating interleukin-10 level [MP:0008594]| increased circulating interleukin-6 level [MP:0008596]| increased circulating interleukin-1 beta level [MP:0008641]| decreased survivor rate [MP:0008770]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal uterine fat pad morphology [MP:0008900]| increased liver triglyceride level [MP:0009355]| decreased liver triglyceride level [MP:0009356]| abnormal synapse morphology [MP:0009538]| increased sensitivity to induced morbidity/mortality [MP:0009763]| abnormal cellular extravasation [MP:0009858]| abnormal aorta elastic tissue morphology [MP:0009862]| abnormal ascending aorta morphology [MP:0009867]| increased total body fat amount [MP:0010024]| decreased liver cholesterol level [MP:0010026]| increased liver cholesterol level [MP:0010027]| increased grip strength [MP:0010052]| increased pruritus [MP:0010072]| aortitis [MP:0010139]| decreased brain cholesterol level [MP:0010161]| decreased susceptibility to weight gain [MP:0010182]| abnormal circulating apolipoprotein level [MP:0010332]| abnormal circulating apolipoprotein E level [MP:0010333]| aorta dilation [MP:0010574]| abdominal aorta aneurysm [MP:0010659]| ascending aorta aneurysm [MP:0010661]| increased aorta wall thickness [MP:0010996]| decreased aorta wall thickness [MP:0010997]| decreased macrophage apoptosis [MP:0011081]| postnatal lethality [MP:0011086]| incomplete penetrance [MP:0011101]| prenatal lethality [MP:0011572]| incomplete penetrance [MP:0011579]| abnormal aorta bulb morphology [MP:0011939]| decreased lipoprotein lipase activity [MP:0011951]| increased food intake [MP:0012223]| increased cardiac stroke volume [MP:0012224]| increased circulating prothrombin level [MP:0012326]| abnormal sterol level [MP:0012355]| increased circulating antithrombin level [MP:0012688]| decreased prothrombin time [MP:0013277]| abnormal heart ventricles weight [MP:0020332]
Affected Gene: |Apobec1||Ldlr||Apob
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No rating or validation information has been found for B6;129-Apobec1tm1Rub Ldlrtm1Her Apobtm1Mae/Mmnc.
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
