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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32103
Proper Citation: RRID:MMRRC_032103-JAX
Description: Mus musculus with name B6.129S6-Ptpn11tm6Bgn/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Hematology, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal bone marrow cell number [MP:0000172]| increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| abnormal erythropoiesis [MP:0000245]| abnormal heart morphology [MP:0000266]| double outlet right ventricle [MP:0000284]| increased granulocyte number [MP:0000322]| decreased bone marrow cell number [MP:0000333]| enlarged liver [MP:0000599]| enlarged spleen [MP:0000691]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| anemia [MP:0001577]| premature death [MP:0002083]| abnormal definitive hematopoiesis [MP:0002123]| thin myocardium [MP:0002652]| increased atrioventricular cushion size [MP:0003808]| heart valve hyperplasia [MP:0003958]| decreased hematopoietic stem cell number [MP:0004810]| abnormal leukopoiesis [MP:0005460]| intermingled spleen red and white pulp [MP:0008475]| decreased cranium height [MP:0008525]| embryonic lethality [MP:0008762]| decreased common myeloid progenitor cell number [MP:0008813]| abnormal splenic cell ratio [MP:0008826]| abnormal liver sinusoid morphology [MP:0008989]| impaired cued conditioning behavior [MP:0009456]| abnormal hippocampus neuron morphology [MP:0009939]| ventricular septal defect [MP:0010402]| atrial septal defect [MP:0010403]| preweaning lethality [MP:0011100]| complete penetrance [MP:0013697]| decreased granulocyte monocyte progenitor cell number [MP:0030166]
Affected Gene: Ptpn11
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
