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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=36953
Proper Citation: RRID:MMRRC_036953-UNC
Description: Mus musculus with name B6.Cg-Smad3tm1Par Smad2tm2Rob Tg(Cd4-cre)1Cwi/2AchMmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal heart development [MP:0000267]| abnormal heart looping [MP:0000269]| enlarged pericardium [MP:0000291]| pericardial edema [MP:0001787]| no abnormal phenotype detected [MP:0002169]| abnormal rostral-caudal axis patterning [MP:0005221]| abnormal anterior definitive endoderm morphology [MP:0008926]| fused somites [MP:0011733]| absent foregut [MP:0012083]| truncated foregut [MP:0012084]| absent midbrain [MP:0012087]| absent forebrain [MP:0012136]| rostral body truncation [MP:0012157]| ruffled hair [MP:0000420]| abnormal rectum morphology [MP:0000492]| rectal prolapse [MP:0000493]| abnormal colon morphology [MP:0000495]| abnormal ovarian folliculogenesis [MP:0001130]| abnormal ovarian follicle morphology [MP:0001131]| decreased body size [MP:0001265]| distended abdomen [MP:0001270]| increased metastatic potential [MP:0001272]| abnormal posture [MP:0001504]| increased circulating follicle stimulating hormone level [MP:0001750]| increased circulating luteinizing hormone level [MP:0001751]| increased inflammatory response [MP:0001846]| reduced female fertility [MP:0001923]| decreased litter size [MP:0001935]| increased adrenal gland tumor incidence [MP:0002031]| premature death [MP:0002083]| abnormal fertility/fecundity [MP:0002161]| abnormal Sertoli cell morphology [MP:0002784]| increased intestinal adenocarcinoma incidence [MP:0002957]| abnormal cytokine secretion [MP:0003009]| colon polyps [MP:0003269]| intestinal obstruction [MP:0003270]| decreased susceptibility to kidney reperfusion injury [MP:0004042]| lethargy [MP:0005202]| decreased oocyte number [MP:0005431]| decreased circulating creatinine level [MP:0005554]| decreased blood urea nitrogen level [MP:0005566]| increased ovary tumor incidence [MP:0008000]| abnormal circulating interleukin-6 level [MP:0008595]| decreased interleukin-6 secretion [MP:0008706]| increased colon adenocarcinoma incidence [MP:0009314]| abnormal secondary ovarian follicle morphology [MP:0009363]| abnormal cumulus expansion [MP:0009373]| increased adenoma incidence [MP:0010383]
Affected Gene: |Smad3|Smad2||Cd4|cre|
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
