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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41278
Proper Citation: RRID:MMRRC_041278-UCD
Description: Mus musculus with name B6.SB-Lynm2Anu/AnuApbMmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation; Mutation Type: chemically induced mutation ; Collection: NHMRC Australian PhenomeBank
Phenotype: decreased mature B cell number [MP:0008211]| increased immature B cell number [MP:0008214]| increased monocyte cell number [MP:0000220]| abnormal mast cell morphology [MP:0000359]| abnormal hair follicle morphology [MP:0000377]| abnormal hair follicle orientation [MP:0000383]| sparse hair [MP:0000416]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| thick epidermis [MP:0001219]| decreased body size [MP:0001265]| absent vibrissae [MP:0001284]| extended life span [MP:0001661]| decreased IgG level [MP:0001805]| abnormal immune cell physiology [MP:0001819]| autoimmune response [MP:0001844]| increased T cell derived lymphoma incidence [MP:0002024]| premature death [MP:0002083]| abnormal kidney morphology [MP:0002135]| abnormal B cell differentiation [MP:0002144]| abnormal lymph node morphology [MP:0002339]| abnormal effector T cell morphology [MP:0002435]| increased IgG level [MP:0002493]| abnormal monocyte morphology [MP:0002620]| abnormal immune serum protein physiology [MP:0002723]| glomerulonephritis [MP:0002743]| decreased erythrocyte cell number [MP:0002875]| increased urine protein level [MP:0002962]| increased autoantibody level [MP:0003725]| abnormal T cell subpopulation ratio [MP:0003944]| increased anti-double stranded DNA antibody level [MP:0004762]| increased anti-single stranded DNA antibody level [MP:0004771]| increased anti-nuclear antigen antibody level [MP:0004794]| decreased anti-nuclear antigen antibody level [MP:0004795]| increased anti-erythrocyte antigen antibody level [MP:0004797]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| increased anti-chromatin antibody level [MP:0004829]| increased spleen weight [MP:0004952]| decreased B cell number [MP:0005017]| increased susceptibility to autoimmune disorder [MP:0005350]| decreased susceptibility to autoimmune disorder [MP:0005351]| increased susceptibility to type III hypersensitivity reaction [MP:0005615]| porphyria [MP:0005654]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008097]| increased plasma cell number [MP:0008182]| decreased marginal zone B cell number [MP:0008470]| abnormal spleen B cell follicle morphology [MP:0008499]| increased IgG1 level [MP:0008500]| increased IgG2a level [MP:0008501]| increased IgG2b level [MP:0008502]| increased IgG3 level [MP:0009060]| increased circulating interleukin-21 level [MP:0009333]| abnormal splenocyte physiology [MP:0009336]| increased splenocyte proliferation [MP:0009338]| increased splenocyte number [MP:0012431]| increased lymphoma incidence [MP:0020519]
Affected Gene: |Lyn|
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No rating or validation information has been found for B6.SB-Lynm2Anu/AnuApbMmucd.
Issue
Warning. Researchers have noted that this genotype does not sufficiently model human systemic lupus erythematosus.
Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
