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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41425
Proper Citation: RRID:MMRRC_041425-UCD
Description: Mus musculus with name B6J.Cg-Aff2tm1Dln Fmr1tm1Cgr/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Cell Biology, Developmental Biology, Metabolism, Models for Human Disease, Neurobiology, Research Tools, Sensorineural; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased body size [MP:0001265]| abnormal cued conditioning behavior [MP:0001454]| abnormal spatial learning [MP:0001463]| premature death [MP:0002083]| abnormal CNS synaptic transmission [MP:0002206]| abnormal excitatory postsynaptic potential [MP:0002912]| enhanced long term potentiation [MP:0003008]| decreased thermal nociceptive threshold [MP:0003998]| abnormal dentate gyrus morphology [MP:0000812]| abnormal Purkinje cell morphology [MP:0000877]| convulsive seizures [MP:0000947]| enlarged testis [MP:0001148]| increased body weight [MP:0001260]| abnormal retina morphology [MP:0001325]| increased aggression towards mice [MP:0001353]| abnormal social investigation [MP:0001360]| social withdrawal [MP:0001361]| abnormal anxiety-related response [MP:0001362]| increased anxiety-related response [MP:0001363]| decreased anxiety-related response [MP:0001364]| hyperactivity [MP:0001399]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| increased stereotypic behavior [MP:0001409]| increased exploration in new environment [MP:0001415]| increased grooming behavior [MP:0001441]| abnormal object recognition memory [MP:0001458]| abnormal spatial learning [MP:0001463]| abnormal contextual conditioning behavior [MP:0001469]| reduced long term potentiation [MP:0001473]| abnormal startle reflex [MP:0001486]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| audiogenic seizures [MP:0001496]| abnormal vocalization [MP:0001529]| abnormal long term depression [MP:0001898]| increased thermal nociceptive threshold [MP:0001973]| abnormal associative learning [MP:0002062]| abnormal learning/memory/conditioning [MP:0002063]| abnormal brain morphology [MP:0002152]| increased vertical activity [MP:0002574]| abnormal hippocampal mossy fiber morphology [MP:0002761]| abnormal eye blink conditioning behavior [MP:0002807]| abnormal response to novelty [MP:0003107]| abnormal locomotor activation [MP:0003313]| abnormal response to novel object [MP:0003461]| abnormal nerve fiber response [MP:0003477]| decreased aggression towards mice [MP:0003863]| tonic-clonic seizures [MP:0003997]| impaired passive avoidance behavior [MP:0004000]| increased testis weight [MP:0004851]| abnormal neuronal precursor proliferation [MP:0004948]| abnormal dendrite morphology [MP:0008143]| abnormal retinal rod cell outer segment morphology [MP:0008456]| increased prepulse inhibition [MP:0009141]| impaired cued conditioning behavior [MP:0009456]| impaired conditioned place preference behavior [MP:0009712]| abnormal dendritic spine morphology [MP:0009936]| abnormal neuron differentiation [MP:0009937]| hypodipsia [MP:0011737]| decreased a wave amplitude [MP:0012143]| decreased b wave amplitude [MP:0012144]| abnormal circadian behavior [MP:0020467]
Affected Gene: |Aff2|Fmr1|
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
