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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=43951
Proper Citation: RRID:MMRRC_043951-JAX
Description: Mus musculus with name B6J(Cg)-Tg(tetO/CMV-ATP2B4,-lacZ)1Husa Tg(Myh6-tTA)6Smbf/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Cardiovascular, Models for Human Disease, Research Tools; Mutation Type: Transgenic ; Collection:
Phenotype: abnormal heart morphology [MP:0000266]| abnormal heart development [MP:0000267]| enlarged heart [MP:0000274]| abnormal myocardial fiber morphology [MP:0000278]| thin ventricular wall [MP:0000280]| alopecia [MP:0000414]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| hypoactivity [MP:0001402]| dehydration [MP:0001429]| decreased grooming behavior [MP:0001442]| hunched posture [MP:0001505]| abnormal cardiovascular system physiology [MP:0001544]| abnormal lipid level [MP:0001547]| cyanosis [MP:0001575]| cardiac hypertrophy [MP:0001625]| irregular heartbeat [MP:0001636]| edema [MP:0001785]| heart inflammation [MP:0001853]| abnormal atrial thrombosis [MP:0001855]| myocarditis [MP:0001856]| respiratory distress [MP:0001954]| premature death [MP:0002083]| disorganized myocardium [MP:0002190]| dilated heart left ventricle [MP:0002753]| dilated cardiomyopathy [MP:0002795]| increased heart weight [MP:0002833]| thick ventricular wall [MP:0002953]| abnormal heart atrium morphology [MP:0003105]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| increased cardiomyocyte apoptosis [MP:0003222]| decreased left ventricle systolic pressure [MP:0003822]| pulmonary edema [MP:0003828]| prolonged PR interval [MP:0003896]| abnormal heart left ventricle morphology [MP:0003921]| abnormal endocardium morphology [MP:0003974]| abnormal P wave [MP:0004070]| prolonged P wave [MP:0004071]| abnormal cardiac muscle relaxation [MP:0004084]| absent heartbeat [MP:0004086]| abnormal atrioventricular node morphology [MP:0004114]| abnormal myocardial fiber physiology [MP:0004215]| enlarged myocardial fiber [MP:0004564]| decreased myocardial fiber number [MP:0004567]| decreased cardiac muscle contractility [MP:0005140]| cachexia [MP:0005150]| lethargy [MP:0005202]| abnormal metabolism [MP:0005266]| abnormal heart ventricle morphology [MP:0005294]| ascites [MP:0005324]| abnormal myocardium layer morphology [MP:0005329]| decreased heart rate [MP:0005333]| hyporesponsive to tactile stimuli [MP:0005498]| decreased ventricle muscle contractility [MP:0005598]| cardiac interstitial fibrosis [MP:0005608]| myocardial necrosis [MP:0006085]| abnormal cardiac outflow tract development [MP:0006126]| congestive heart failure [MP:0006138]| decreased systemic arterial systolic blood pressure [MP:0006264]| dilated heart ventricle [MP:0008022]| atrial fibrillation [MP:0008543]| increased heart ventricle size [MP:0008772]| abnormal cardiac epithelial to mesenchymal transition [MP:0008825]| ventricular tachycardia [MP:0008950]| pulmonary vascular congestion [MP:0010018]| liver vascular congestion [MP:0010019]| decreased skeletal muscle weight [MP:0010239]| pleural effusion [MP:0010334]| prolonged QRS complex duration [MP:0010392]| abnormal ventricle endocardium morphology [MP:0010494]| abnormal T wave [MP:0010505]| atrioventricular block [MP:0010519]| heart block [MP:0010559]| cardiac muscle necrosis [MP:0010632]| myocardial hypertrophy [MP:0010633]| lethality throughout fetal growth and development [MP:0011099]| complete penetrance [MP:0011101]| prenatal lethality [MP:0011108]| incomplete penetrance [MP:0011925]| embryonic lethality during organogenesis [MP:0011940]| incomplete penetrance [MP:0011953]
Affected Gene: ATP2B4||lacZ|||Myh6||tTA
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
