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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170599
Proper Citation: RRID:RGD_626170599
Description: Rattus norvegicus with name LE-Syngap1em1Sidb from RGD.
Species: Rattus norvegicus
Notes: This KO allele was generated by Sigma Advanced Genetic Engineering (SAGE) Labs (St. Louis, MO, US) by injecting CRISPR/Cas9 reagents and sgRNA targeting exon 8 (gtgcatagagcatgtcgtccAGG) into Long Evans (LE) zygotes. Founder #23 displayed a 2bp deletion and 1bp insertion, leading to a frameshift mutation in exon 8 of Syngap1, which prevents expression of the protein. Homozygous Syngap1 KO rats die perinatally, but heterozygous Syngap1 KO rats appear healthy and are fertile. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
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Source: Rat Genome Database (RGD) (RRID:SCR_006444)
Description: Database for genetic, genomic, phenotype, and disease data generated from rat research. Centralized database that collects, manages, and distributes data generated from rat genetic and genomic research and makes these data available to scientific community. Curation of mapped positions for quantitative trait loci, known mutations and other phenotypic data is provided. Facilitates investigators research efforts by providing tools to search, mine, and analyze this data. Strain reports include description of strain origin, disease, phenotype, genetics, immunology, behavior with links to related genes, QTLs, sub-strains, and strain sources.
URL: http://rgd.mcw.edu
Source Database: Rat Genome Database (RGD)
