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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=222
Proper Citation: RRID:MMRRC_000222-UNC
Description: Mus musculus with name STOCK Cd4tm1Litt Tg(Cd4-CD4)2362Litt/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Developmental Biology, Hematology, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Transgenic ; Collection:
Phenotype: enlarged lymph nodes [MP:0000702]| premature death [MP:0002083]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal immune system organ morphology [MP:0002722]| abnormal cytokine secretion [MP:0003009]| absent CD4-positive [MP:0003790]| alpha beta T cells [MP:0005010]| abnormal CD8-positive [MP:0005090]| alpha beta T cell morphology [MP:0005095]| increased double-negative T cell number [MP:0005348]| decreased T cell proliferation [MP:0005463]| increased T cell proliferation [MP:0005466]| abnormal CD4-positive [MP:0006413]| alpha-beta T cell physiology [MP:0008075]| abnormal T-helper 2 physiology [MP:0008078]| increased T cell apoptosis [MP:0008560]| decreased CD4-positive [MP:0008698]| alpha beta T cell number [MP:0008699]| increased CD8-positive [MP:0008705]
Affected Gene: Cd4|CD4|||Cd4
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No rating or validation information has been found for STOCK Cd4tm1Litt Tg(Cd4-CD4)2362Litt/Mmnc.
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
