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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=439
Proper Citation: RRID:MMRRC_000439-UNC
Description: Mus musculus with name STOCK Pdx1tm1Cvw/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Diabetes, Endocrine Deficiency, Research Tools; Mutation Type: Targeted Mutation ; Collection: BCBC-Beta Cell Biology Consortium
Phenotype: sparse hair [MP:0000416]| abnormal stomach morphology [MP:0000470]| abnormal foregut morphology [MP:0000474]| abnormal small intestine morphology [MP:0000496]| abnormal liver development [MP:0000596]| thin skin [MP:0001199]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| dehydration [MP:0001429]| hyperglycemia [MP:0001559]| postnatal growth retardation [MP:0001732]| increased urine glucose level [MP:0001759]| abnormal pancreas morphology [MP:0001944]| decreased circulating insulin level [MP:0002727]| increased insulin sensitivity [MP:0002891]| abnormal bile duct development [MP:0002929]| decreased insulin secretion [MP:0003059]| abnormal duodenum morphology [MP:0003271]| decreased pancreatic beta cell number [MP:0003339]| abnormal pancreatic beta cell physiology [MP:0003562]| absent pancreas [MP:0003655]| small pancreas [MP:0004247]| abnormal pancreatic islet morphology [MP:0005215]| abnormal pancreatic beta cell morphology [MP:0005217]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| increased circulating glucose level [MP:0005559]| decreased pancreas weight [MP:0009109]| abnormal pancreatic duct morphology [MP:0009143]| abnormal pancreatic acinar cell morphology [MP:0009146]| abnormal pancreatic islet size [MP:0009170]| small pancreatic islets [MP:0009172]| abnormal pancreatic beta cell differentiation [MP:0009175]| increased pancreatic alpha cell number [MP:0009176]| increased pancreatic delta cell number [MP:0009180]| disorganized pancreatic islets [MP:0009254]| abnormal pyloric sphincter morphology [MP:0009861]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011820]| decreased pancreatic beta cell proliferation [MP:0012520]| absent Brunner's glands [MP:0014109]| increased pancreatic alpha cell proliferation [MP:0014117]
Affected Gene: Pdx1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
