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URL: http://www.wormbase.org/db/get?name=WBStrain00026463
Proper Citation: RRID:WB-STRAIN:WBStrain00026463
Description: Caenorhabditis elegans with name mei-1(ct46) unc-13(e1091) I; unc-119(ed3) III; abcIs3. from WB.
Species: Caenorhabditis elegans
Synonyms: mei-1(ct46) unc-13(e1091) I; unc-119(ed3) III; abcIs3.
Notes: abcIs3 [pie-1p::ebp-2::GFP + unc-119(+)]. Embryonic-lethal at 25C due to dominant gain-of-function mutation mei-1(ct46), and Uncoordinated due to unc-13 mutation. Maternal expression of EBP-2::GFP microtubule end-binding protein. EBP-2 encodes an EB1-like protein (end-binding) that, in early embryos, locates to the growing tips of microtubules. A strong fluorescent signal localizes to the centrosomes of early embryos due to a high concentration of polymerizing microtubules. mei-1(ct46)-based ectopic microtubule severing causes mitotic spindle defects in the early embryo. References: Gusnowski EM, Srayko M. J Cell Biol. 2011 Aug 8;194(3):377-86. Tegha-Dunghu J, et al. Methods Mol Biol. 2014;1136:103-16.
Affected Gene: WBGene00003183(mei-1)|WBGene00006752(unc-13)|WBGene00006843(unc-119)
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Source: Integrated Animals
Source Database: WormBase (WB)
