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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
Offers investigators clinical space, equipment, skilled nursing and nutrition services, project management and study coordinator support, resources for conducting community engagement research, as well as one-on-one consultation with Clinical/Translational Research Navigators.
Proper citation: BIDMC Clinical Research Center Clinical Services Core Facility (RRID:SCR_027766) Copy
https://imaging.uci.edu/fibre/
Facility for Imaging and Brain Research houses 3T Siemens Prisma scanner, mock scanner, and data analysis facilities. Research dedicated MRI scanning facility designed to suit wide range of basic and translational research programs by researchers across the UCI campus and beyond.
Proper citation: University of California at Irvine FIBRE Core Facility (RRID:SCR_027777) Copy
https://www.mskcc.org/research/ski/core-facilities/integrated-genomics-operation-igo
Core provides services and expertise to Center investigators interested in evaluating gene expression, chromosome structure, and nucleotide sequence on a broad scale. Enables basic, clinical, and translational research projects across the Center. Through its production group, the Core enables genomic and transcriptomic analyses and has the expertise to process challenging samples from all origins (tissue, dissociated single cells and cell pellets, paraffin curls, blood, serum, etc.). Bulk DNA/RNA assays operate in highly automated environment, from sample reception to sequencing library preparation.
Proper citation: Memorial Sloan Kettering Cancer Center Integrated Genomics Operation Core Facility (RRID:SCR_027801) Copy
https://www.mskcc.org/research/ski/core-facilities/nuclear-magnetic-resonance-analytical
Core provides analytical services, access and education for analytical instrumentation and related shared scientific resources. Instrumentation includes high field nuclear magnetic resonance, mass spectrometry and optical spectroscopic instruments. Facility offers investigators the ability to monitor chemical reactions, analysis for determination of molecular structure, chemical mechanisms, purity, stability, biological uptake and other properties of chemical compounds.
Proper citation: Memorial Sloan Kettering Cancer Center Nuclear Magnetic Resonance (Analytical) Core Facility (RRID:SCR_027804) Copy
https://www.mskcc.org/research/ski/core-facilities/mouse-genetics
Core facilitates the use of mouse molecular genetics at MSK for in vivo studies of gene functions germane to cancer. Provides expertise in generation and effective use of genetically engineered mouse (GEM) models—namely, molecular and cell biology, embryo micromanipulation, and reproductive biology. Molecular and cellular biology services cover design and assembly of genome engineering reagents, such as donor transgenes and CRISPR/Cas9; performing all aspects of gene targeting in mouse embryonic stem (ES) cells; identification and verification of alleles carried by a generated GEM model; and establishment of new ES cells from a variety of GEM lines. Provides consultation and training for the design and production of GEM models, ES cell culture and manipulation, and mouse reproduction and genetic crosses.
Proper citation: Memorial Sloan Kettering Cancer Center Mouse Genetics Core Facility (RRID:SCR_027803) Copy
https://www.mskcc.org/research/ski/core-facilities/pro-cel
Core supports MSK investigators who wish to capture self-reported information from culturally diverse patients, caregivers, clinical staff, and community members. The faculty of the PRO-CEL Core are nationally recognized social and behavioral scientists and community engagement experts who provide technical assistance to all users throughout multiple stages of research, including grant and protocol development, research study assistant and support staff training, and result dissemination. Provides methodological support for clinical trial, behavioral, and population-based research that seeks to engage community or minority populations.
Proper citation: Memorial Sloan Kettering Cancer Center Patient- Reported Outcomes, Community Engagement, and Language Core Core Facility (RRID:SCR_027805) Copy
https://www.vai.org/research/core-services/spatial-collaborative-services/
Spatial Collaborative Services combines expertise and technology from VAIs Genomics Core and Optical Imaging Core to offer investigators a seamless pipeline for spatial imaging. Services include consultation, histology preparation, sequencing and imaging based spatial platforms.
Proper citation: Van Andel Institute Spatial Collaborative Services Core Facility (RRID:SCR_027861) Copy
https://www.augusta.edu/research/core/medical-sculpture.php
Department of Medical Illustration’s Medical Sculpture Core advances education and research capabilities in medical sculpture. The space serves as an AU Core Research Lab to provide expertise in medical sculpture, volumetric visualization, and 3D printing. This lab space will offer educational and research opportunities for students to develop medical models such as surgical simulation models and patient education models. The research will improve surgical and medical training and provide insight into materials and technology to improve patient care.
Proper citation: Augusta University Medical Sculpture Core Facility (RRID:SCR_027863) Copy
https://mic.massgeneralbrigham.org
Core facility that provides microscopy training, imaging solutions, image processing and analysis services, and consultation. Offers imaging techniques and expertise, including spinning disc confocal microscopy, two-photon confocal microscopy, super resolution microscopy, total internal reflection microscopy, wide field microscopy, fluorescence spectroscopy, photo-manipulation techniques (e.g. FRAP, photoablation, optogenetics, and optical tweezers) and live cell imaging.
Proper citation: Massachusetts General Hospital Brigham Center of Excellence for Molecular Imaging Core Facility (RRID:SCR_027865) Copy
Core for building and testing mobility innovation is part of the University of Michigan Transportation Research Institute. Helps advance safe and efficient transportation and mobility solutions. Makerspace for mobility and transportation innovators. Offers open-source tools, remote or on-site testing.
Proper citation: University of Michigan MCity Core Facility (RRID:SCR_027857) Copy
https://cryo-em.charite.de/en/
Facility for high resolution imaging of biological samples at cryogenic temperatures. Amongst other applications such as single particle data collection, our high-end instrumentation is suited to perform in situ structural biology by combining cryoCLEM, lamella FIB-milling, and cryo-electron tomography.
Proper citation: Charité Berlin University of Medicine Cryo-Electron Microscopy Core Facility (RRID:SCR_027961) Copy
https://experimentelle-medizin.charite.de/en/transgenic_technologies
Core provides services supporting generation, modification, cryopreservation, and rederivation of genetically modified rodent models for biomedical research, generates genetically modified mouse models via both targeted and random mutagenesis using tools such as CRISPR/Cas9 in zygotes or embryonic stem (ES) cells, provides cryopreservation and rederivation of existing animal models to preserve hygienic integrity. Services for rodent transgenic model development include: Pronuclear Injection and amp; Viral Transgenesis with introduction of genetic constructs into zygotes using microinjection or lentiviral systems; ES Cell-Based Techniques: use of embryonic stem cell manipulation for genetic targeting; Embryo Transfer: transferring manipulated embryos into recipient females; In Vitro Fertilization (IVF): assisted reproductive technology to generate embryos for manipulation or cryopreservation; Cryopreservation: freezing of embryos and sperm for archiving or rederivation of lines as required. Facility’s expertise includes quality control of cryopreserved material to ensure viability upon thawing.
Proper citation: Charité Berlin University of Medicine Transgenic Technologies Core Facility (RRID:SCR_027960) Copy
Core provides comprehensive services for generation of viral particles from existing vectors or newly created vectors.
Proper citation: Charité Berlin University of Medicine Viral Core Facility (RRID:SCR_027965) Copy
https://www.mayo.edu/research/core-resources/precision-mouse-engineering-core/overview
Core generates transgenic and gene-targeted mice for researchers at Mayo Clinic's campuses in Arizona, Florida and Minnesota to enable researchers to observe how genes, or mutant variations of genes, are expressed. Provides services to all Mayo Clinic faculty and staff engaged in research. Also, services are offered to non-Mayo investigators and research collaborators.
Proper citation: Mayo Clinic Precision Mouse Engineering Core Facility (RRID:SCR_027967) Copy
https://www.mayo.edu/research/core-resources/biomedical-imaging-resource-core/overview
Mayo Clinic's Biomedical Imaging Resource Core in Rochester, Minnesota, focuses on supporting and advancing research in biomedical imaging and visualization sciences. Provides guidance on protocol design, routine image analysis, and custom software and hardware solutions. Also, media and model production resources are available to investigators for the creation of high-quality visualizations and physical models of research data.Core provides services to all Mayo Clinic faculty and staff engaged in research. Also, services may be available on a limited basis to investigators and research collaborators outside Mayo Clinic. Before scheduling, contact the core to design optimal settings for the specified imaging task.
Proper citation: Mayo Clinic Biomedical Imaging Resource Core Facility (RRID:SCR_027968) Copy
https://www.lsuhs.edu/centers/center-for-post-transcriptional-regulation/research-cores
Core enables generation of genetically defined human iPSC-derived hepatocytes, CRISPR/Cas9 mediated gene editing, and primary mouse hepatocyte isolation.
Proper citation: Louisiana State University Health Sciences Center Shreveport hiPSC and Cell Models Core Facility (RRID:SCR_027946) Copy
https://mass-spec.wp.st-andrews.ac.uk/
Core provides services in mass spectrometry including protein identification and analysis, measuring the intact mass of proteins and quantitative proteomics.
Proper citation: University of St Andrews Mass Spectrometry and Proteomics Core Facility (RRID:SCR_027881) Copy
https://github.com/schwartzlab-methods/CellNEST
Software tool to decipher patterns of communication. Used to relay-network communication detection that identifies putative ligand–receptor–ligand–receptor communication. Detects T cell homing signals in human lymph nodes, identifies aggressive cancer communication in lung adenocarcinoma and colorectal cancer, and predicts new patterns of communication that may act as relay networks in pancreatic cancer.
Proper citation: CellNEST (RRID:SCR_027883) Copy
https://health.ucdavis.edu/cancer/research/sharedresources/mouse
Mouse Biology Shared Resource (MBSR) provides knockout, transgenic, and humanized murine cancer models and related services for advancing translational cancer research. Additionally, the MBSR offers services to enhance the use of existing mouse models or to facilitate the development of new mouse models for cancer research, including genetic alteration (e.g., CRISPR/Cas9-mediated gene targeting, transgenesis), surgical manipulation (e.g., patient-derived xenografts (PDX), cell-derived allografts (CDA) and xenografts (CDX)), and environmental challenges (e.g., diet, chemotherapeutic agents). can produce a wide range of allele-speci?c mouse models and offers innovative technologies to phenotype mouse models that mimic human conditions.
Proper citation: UC Davis Health Comprehensive Cancer Center Mouse Biology Shared Resource MBSR Core Facility (RRID:SCR_027912) Copy
https://www.uvic.ca/science/biology/research/facilities/em-lab
Electron microscopy core provides microscopy and image analysis, applications development, and services.
Proper citation: University of Victoria Biology Electron Microscopy Laboratory Core Facility (RRID:SCR_027894) Copy
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