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http://academicdepartments.musc.edu/aging/

A center dedicated to research, service, and education concerning aging. MUSC primarily promotes the health, increased longevity, and improved quality of life of senior South Carolinians. This organization does such through the establishment of a national translational research program about aging, the development of a comprehensive/coordinated system of health care delivery for older individuals, and providing health education and outreach to students, faculty members, practicing health providers and the overall public. This center consists of several different research programs, including the Movement Disorder program, Stroke program, Alzheimer's program, Biology of Aging program, Outreach and Education program, and the Clinical Geriatric program.

Proper citation: Medical University of South Carolina Center on Aging (RRID:SCR_008825) Copy   

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http://www.mssm.edu/research/centers/alzheimers-disease-research-center/

A research facility and clinical program that is dedicated to the study and the treatment of both normal aging and Alzheimer's disease. This facility will accommodate requests for its resources (for example, data or tissue) from investigators that are not funded by the ADRC. Their team is composed of experts in geriatrics, geriatric psychiatry and psychology, neurology, pathology, and radiology. All team members work to provide services to those with memory disorders. This center sponsors educational programs for healthcare professionals and community groups. Data from the ADRC cores are available to all ADRC investigators after approval from the PI who collected the data. Data generated by the ADRC cores are communicated to the National Alzheimer's Coordinating Center (NACC) and can be available through them. Tissue can be distributed after approval of the Tissue Allocation Committee, and can be used for further research.

Proper citation: Mount Sinai Alzheimer's Disease Research Center (RRID:SCR_008780) Copy   

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http://depts.washington.edu/adrcweb/

Research center investigating the basic mechanisms underlying the development of Alzheimer's disease and related disorders, directing particular attention to biomarkers and experimental new treatments. They also continue to search for genetic risk factors underlying Alzheimer's disease (AD). Their main priorities are to find causes, effective treatments, and prevention strategies. Their investigators also are partnering with other Alzheimer's Centers across the country to evaluate promising new medications and other treatments for AD. The ultimate goal of their basic and clinical studies is to improve patient care and function, and improve the quality of life for both the patient and the caregiver. ADRC Cores: * Administration * Clinical Core * Satellite Core * Data Management & Biostatistics * Neuropathology Core * Education & Information Transfer * Genetics

Proper citation: University of Washington Alzheimers Disease Research Center (RRID:SCR_008814) Copy   

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http://alzheimers.med.umich.edu/research/resources-for-investigators/

An organization that provides scientists with human tissue from Alzheimer's patients and patients with related brain disorders. Brain tissue is collected from research studies at the University of Michigan, as well as other research centers, and are donated by the families of the patients or the participants themselves. Tissues that are present in the Brain Bank are pre-characterized by pathologists and can be provided to researchers upon request.

Proper citation: Michigan Alzheimer's Disease Center Brain Bank (RRID:SCR_008774) Copy   

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http://www.opwdd.ny.gov/institute-for-basic-research/home

A research arm of the New York State Office for People with Developmental Disabilities (OPWDD), which conducts basic and clinical research into the causes, treatment, and prevention of intellectual disabilities and other developmental disabilities. The goals of the IBR's research, services and education program are designed to provide prevention, earlier detection, and improved treatment of intellectual disabilities and other developmental disabilities. This research program has a total of 46 laboratories over 7 departments. These programs include the George A. Jervis Clinic (a tertiary-level diagnostic and research clinic), the Specialty Clinical Laboratories (conduct specialty testing for genetic, metabolic, neurodegenerative disorders), and the Comprehensive Genetic Disease Program at Richmond County (provides genetics and genetic counseling services). This institute provides educational activities in the graduate studies program, and the Programs in Developmental Neuroscience and Developmental Disabilities (PDNDD). The PDNDD collaborates with the faculty from the City University of New York and the State University of New York. The IBR staff regularly conducts public education workshops and professional seminars about developmental disabilities.

Proper citation: Institute for Basic Research in Developmental Disabilities (RRID:SCR_008806) Copy   

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http://www.utsouthwestern.edu/education/medical-school/departments/neurology/programs/alzheimers-disease-center/index.html

A center dedicated to discovering treatments and providing preventative measures for Alzheimer's Disease. Research is strongly focused on brain changes in regards to healthy aging, mild cognitive impairment and other disorders, such as dementia. It aims to improve diagnostic measures and care giving techniques, discover more effective medical interventions, and understand the etiology of the disease and find an eventual cure. The center provides diagnostic evaluations of adult memory problems, as well as the opportunity to participate in clinical research to aid in finding better Alzheimer's treatments.

Proper citation: University of Texas Southwestern Medical Center - Alzheimer's Disease Center (RRID:SCR_008836) Copy   

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https://www.musc.edu/website/research/brainbank/braindonor.html

A brain bank and biospecimen repository that provides research materials to clinicians, scientists and pathologists in South Carolina. The bank provides both control and diseased biospecimens and brain tissue needed for research in Alzheimer's disease, Parkinson's disease and other related neurological disorders. The Campbell Laboratory coordinates the brain tissue donation program, provides post-mortem confirmation of a patient having neurological disorders, and leads research trials. Any South Carolina resident can choose to sign up as a tissue donor and have their brain tissue donated post-mortem to be used for neurological disorder research. The tissue bank will process and analyze these tissue samples and send the results to the deceased person's family.

Proper citation: MUSC Center on Aging Campbell Neuropathology Laboratory (RRID:SCR_008826) Copy   

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http://tools.researchonresearch.org/dodsg/web/WebDatabaseHTML.php?service=detail&id=64

THIS RESOURCE IS NO LONGER IN SERVICE, documented on Septemeber 02, 2014. Through a collaborative effort with experts in doctor-elderly patient interaction who participated in the development of ADEPT, a database of approximately 435 audio and video tapes of visits of patients age 65 and older (n=46) to their primary physician was established for testing ADEPT and for access by medical educators and researchers. Data associated with each tape include reason for visit, physician characteristics (age, race, gender), patient characteristics (age, race, gender), companion characteristics (age, race, gender), and length of doctor-patient relationship. Through a collaborative effort with experts in doctor-elderly patient interaction who participated in the development of ADEPT, a database of approximately 435 audio and video tapes of visits of patients age 65 and older (n=46) to their primary physician was established for testing ADEPT and for access by medical educators and researchers. Data associated with each tape include reason for visit, physician characteristics (age, race, gender), patient characteristics (age, race, gender), companion characteristics (age, race, gender), and length of doctor-patient relationship. Patient visits to their primary physician were videotaped at four sites: an academic medical center in the Midwest, an academic medical center in the Southwest, a suburban managed care medical group, and an urban group of physicians in independent practice. Repeat visits between the same doctor and patient were taped for 19 patients resulting in 48 tapes of multiple visits. Patients were recruited in the waiting room for a convenience sample. Before the visit, patients provided demographic data and completed a global satisfaction form. Following the visit, patients completed the SF-36, and the ABIM for patient satisfaction. Two weeks following the visit, patients were contacted by telephone and asked about their understanding, compliance and their utilization of health services over the past year. At twelve months, patients were contacted by telephone for administration of the SF-36, the global satisfaction form, and the utilization of health services survey. Data Availability: Archived at the Saint Louis University School of Medicine Library. Interested researchers and medical educators should contact the PI, Mary Ann Cook, JVCRadiology (at) sbcglobal.net * Dates of Study: 1998-2001 * Study Features: Longitudinal, Anthropometric Measures * Sample Size: 46

Proper citation: ADEPT - Assessment of Doctor-Elderly Patient Encounters (RRID:SCR_008901) Copy   

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http://trans.nih.gov/bmap/index.htm

The Brain Molecular Anatomy Project is a trans-NIH project aimed at understanding gene expression and function in the nervous system. BMAP has two major scientific goals: # Gene discovery: to catalog of all the genes expressed in the nervous system, under both normal and abnormal conditions. # Gene expression analysis: to monitor gene expression patterns in the nervous system as a function of cell type, anatomical location, developmental stage, and physiological state, and thus gain insight into gene function. In pursuit of these goals, BMAP has launched several initiatives to provide resources and funding opportunities for the scientific community. These include several Requests for Applications and Requests for Proposals, descriptions of which can be found in this Web site. BMAP is also in the process of establishing physical and electronic resources for the community, including repositories of cDNA clones for nervous system genes, and databases of gene expression information for the nervous system. Most of the BMAP initiatives so far have focused on the mouse as a model species because of the ease of experimental and genetic manipulation of this organism, and because many models of human disease are available in the mouse. However, research in humans, other mammalian species, non-mammalian vertebrates, and invertebrates is also being funded through BMAP. For the convenience of interested investigators, we have established this Web site as a central information resource, focusing on major NIH-sponsored funding opportunities, initiatives, genomic resources available to the research community, courses and scientific meetings related to BMAP initiatives, and selected reports and publications. When appropriate, we will also post initiatives not directly sponsored by BMAP, but which are deemed relevant to its goals. Posting decisions are made by the Trans-NIH BMAP Committee

Proper citation: BMAP - Brain Molecular Anatomy Project (RRID:SCR_008852) Copy   

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http://www.fli-leibniz.de/

The Leibniz Institute for Aging Research - Fritz Lipmann Institute (FLI) is the first national research institute in Germany that deals with biomedical research into human aging. Aging is a multifactorial process that is influenced by the environment and genetic factors.

Proper citation: Fritz Lipmann Institute; Jena; Germany (RRID:SCR_011250) Copy   

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http://www.mst.edu/

Founded in 1870 as one of the first technological schools west of the Mississippi, Missouri S&T is one of the nation''s top technological research universities. Missouri S&T produced the engineers, scientists and innovators who helped drive the Industrial Revolution and launch the Space Age. Today, our graduates are poised to lead the new global, green economy.

Proper citation: Missouri University of Science and Technology; Missouri; USA (RRID:SCR_011396) Copy   

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http://www.progeriaresearch.org/index.html

The mission of The Progeria Research Foundation is to discover treatments and the cure for Progeria, and its aging related disorders. Progeria is a rare and fatal genetic disease characterized by an appearance of accelerated aging in children. Without the discovery of new treatments, all children with Progeria will die of heart disease at an average age of 13 years. The Progeria Research Foundation (PRF) was founded in 1999 in response to the complete lack of progress being made to help children with Progeria. We have filled a void, taking these children out of the background where they had been for over 100 years and putting them and Progeria at the forefront of scientific efforts. In just 11.5 years, we have achieved extraordinary progress towards our mission: the Progeria gene discovery in 2003, first-ever clinical drug trials initiated in 2007, extensive global awareness of the disease and PRF''s work, and discovery of critical biological links between Progeria, heart disease and aging we all experience.

Proper citation: Progeria Research Foundation (RRID:SCR_012786) Copy   

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http://www.ncl.ac.uk/ion/research/themes/

This resource provides detailed information about the major research themes in the Institute of Neuroscience at the New Castle University. The major research themes of this department include: * Behavior, Psychology and Cognitive Neurosciences * Developmental Neuroscience, Aging and Neurodegeneration * Neural Circuits and Neuroimaging * Neurology, Neurosurgery, and Motor Control * Neuropharmacology and Neurotechnology * Psychiatric Neurosciences * Visual, Auditory and Sensory Neuroscience

Proper citation: New Castle University, The Institute of Neuroscience: Major Research Themes (RRID:SCR_012952) Copy   

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http://projectreporter.nih.gov/project_info_description.cfm?aid=8662111&icde=19363315&ddparam=&ddvalue=&ddsub=&cr=2&csb=default&cs=ASC

A multi-center and multi-disciplinary study designed to dramatically increase understanding of chronic traumatic encephalopathy (CTE) and other late effects of traumatic brain injury (TBI). Overlapping clinical features, postmortem pathologies and patterns of involvement exist in TBI, CTE, and Alzheimer''s disease pose challenges to accurate diagnosis. Premortem diagnosis of CTE is currently impossible. The neuropathological consequences of single mild or moderate-severe TBI and its relationship with CTE and known dementias are unclear. The proposed project will leverage extensive resources from an ongoing population-based prospective cohort study of brain aging (Adult Changes in Thought; ACT, n=2,305) which includes excellent medical, behavioral, and genetic characterization of a cohort (20% of whom have a history of mild-moderate TBI) in addition to state-of-the-art neuropathology workup upon death. Neuropathological study of TBI effects can begin immediately in the existing ACT autopsy sample (n=489, 20% with TBI exposure). Additional cohorts of TBI- exposed individuals will come from the Brain Injury Research Center at Mount Sinai (n=150 individuals with moderate-severe TBI), the University of Texas Southwestern (n=50 retired boxers with repetitive TBI exposure), and the National Football League (n=76 retired players with repetitive TBI exposure). All participants in the proposed study (ACT and other sites) will undergo uniform harmonized neurobehavioral assessment (chosen to maximize correspondence with existing large-scale TBI and dementia studies), MRI scan, and genomic analysis. Those individuals who expire during the course of the study will undergo ex-vivo neuroimaging and extensive neuropathological exam using state-of-the-art techniques (such as Histelide) designed to quantify tau and A�� in whole brain specimens. Only by examining postmortem pathology in a sample of individuals with varying levels of TBI exposure who are well characterized during life (as proposed herein) can postmortem pathology facilitate identification of in-vivo biomarkers that can act as diagnostic tools. This project represents the most systematic and scientifically rigorous effort to date to develop a more complete understanding of the long-term clinical and neuropathological sequelae of single and multiple TBI.

Proper citation: Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo Diagnostics (RRID:SCR_012951) Copy   

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http://www.primate.wisc.edu/

Research center aimed towards increasing understanding of basic primate biology and improving human health and quality of life. Its goals include helping discover treatments, preventative measures and cures for human disease; gathering knowledge of primate biology and ecosystems; providing resources to scientists world wide; and collecting and disseminating research to the larger scientific community and public.

Proper citation: Wisconsin National Primate Research Center (RRID:SCR_012987) Copy   

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http://www.brain.northwestern.edu/research/for-researchers/index.html

Tissue bank for collecting, cataloging and storing postmortem brain tissue samples from subjects with and without neurological disorders. Specimens are available for research on cognitive impairment, Alzheimer's, dementia and other disorders along with clinical data such as demographic information, health and family history and neuropsychological test scores. The bank provides services to distribute postmortem brain tissue and other samples to investigators for use in research that will provide qualitative and quantitative diagnostic information to physicians, families, and researchers.

Proper citation: Northwestern CNADC Tissue Bank / Neuropathology Core (RRID:SCR_013178) Copy   

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http://brain.ubc.ca/

Research facility for research on neurological and psychiatric disorders on the learning brain and the aging brain. The Centre utilizes a multidisciplinary approach to explore the causes and potential treatments of disorders like Alzheimer's disease, mental health and addiction, stroke and neurotrauma. The Centre focuses on translating research into patient care and therapies.

Proper citation: Djavad Mowafaghian Centre for Brain Health (RRID:SCR_013149) Copy   

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http://www.siumed.edu/alz/index.html

Resource center that provides assistance for patients and families affected by Alzheimer's disease and related conditions. The Center provides patient care through the Memory and Aging Clinic as well as through research, education and service to the community. Additionally the Center provides training in dementia care, maintains centralized data collection, and sponsors programs of research that qualify for federal financial participation.

Proper citation: SIU Center for Alzheimer's Disease and Related Disorders (RRID:SCR_013199) Copy   

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http://www.ohsu.edu/xd/health/services/brain/

A clinical care and research center for neurological conditions such as Alzheimer's, dementia and seizure disorders. It provides a dynamic setting for training healthcare professionals and neuroscience researchers to develop and implement evidence-based treatment.

Proper citation: OHSU Brain Institute (RRID:SCR_008932) Copy   

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http://gero.usc.edu/CBPH/network/index.shtml

A network to improve measurement of biological risk for late life health outcomes in large representative samples of populations. Activities of the network include designing and carrying out a series of focused meetings, interactive activities, workshops, and pilot projects to harmonize and develop measurement of biological risk in populations. This project will improve the methods of measuring health used in populations and improve comparability of results over time and across studies, which is important for monitoring population health. Biological risk represents objective measurement of major dimensions of population health. The level of risk can indicate the health of the population, need for health care treatment in a population, and the effectiveness of that treatment in controlling risk or delaying disease progression, and death. The measurement of biological risk in large populations often requires adoption of methods not used in laboratory settings. The overarching goal of the network is to promote interdisciplinary research that clarifies the biological paths to health outcomes that can be measured or monitored in population surveys. The network will address the following questions: * What array of biological markers can be included reliably and validly in population studies in order to better monitor health and predict health outcomes at the older ages? * What are the best methods of collecting biological risk information under a variety of circumstances? * What are the best methods for processing the biological risk information collected? * What methods of harmonization will allow us to compare biological risk across studies? * What are the best approaches to measurement of cumulative biological risk or dimensions of biological risk for a variety of health outcomes in a variety of settings? * What are the best approaches in including indicators of genetic risk for complex diseases and conditions into data from population-based surveys? * How do we best capture indicators of life-long social, psychological and economic conditions along with lifelong biological risk to explain later life health outcomes? * What particular ethical issues are posed by our linking of biological data to extensive social, psychological, and economic information? A dataset of descriptions of Selected Population Studies with Biomarkers is available.

Proper citation: Biomarker Network (RRID:SCR_008951) Copy   

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