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We are the Computational Biology and Bioinformatics Group of the Biosciences Division of Oak Ridge National Laboratory. We conduct genetics research and system development in genomic sequencing, computational genome analysis, and computational protein structure analysis. We provide bioinformatics and analytic services and resources to collaborators, predict prospective gene and protein models for analysis, provide user services for the general community, including computer-annotated genomes in Genome Channel. Our collaborators include the Joint Genome Institute, ORNL''s Computer Science and Mathematics Division, the Tennessee Mouse Genome Consortium, the Joint Institute for Biological Sciences, and ORNL''s Genome Science and Technology Graduate Program.
Proper citation: Computational Biology at ORNL (RRID:SCR_005710) Copy
http://neuroamer.wordpress.com/
Neuroamer is a researcher-oriented blog about neuroscience, psychiatry, and psychology. It is an attempt to fill the space between journal articles and pop science journalism.
Proper citation: Neuroamer (RRID:SCR_000624) Copy
http://www.genetics.med.ed.ac.uk/blog/
This resource aims to provide information for the general public on the background and current progress of scientific research into the role of genetics in these disorders. Additionally, it also aims to provide a forum for the discussion of aspects of psychiatric genetics open to members of the research community.
Proper citation: Schizophrenia and Bipolar Disorder Genetics Blog (RRID:SCR_001541) Copy
http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-335
Cell signaling pathways can be explored using PathFinder, the interactive, online graphical representation of cell signaling pathways. The user can use PathFinder to explore the relationships between different cell signaling pathway components while being presented with our high quality small molecules, antibodies, enzymes, siRNA for gene knockdown and qPCR components to aid them in their research.
Proper citation: Cell Signaling Pathways (RRID:SCR_002070) Copy
http://www.angis.org.au/Databases/Heart/
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The aim of this locus-specific mutation database was to provide an online resource that contains summarized and updated information on familial hypertrophic cardiomyopathy (FHC)-associated mutations and related data, for researchers and clinicians. It also serves as a means of publishing previously unpublished data, which could be of value in understanding genotype/phenotype correlations. This database contains mutations in various genes known to cause familial hypertrophic cardiomyopathy, a genetic disorder associated with defects in the sarcomere [1]. Only gene symbols approved by HUGO are used and mutations are reported in accordance with guidelines recommended by the Mutation Database Initiative of HUGO and EBI.
Proper citation: Familial Hypertrophic Cardiomyopathy DNA Mutation Database (RRID:SCR_002346) Copy
Center for patient care, education and research on cancer. The institute focuses its research on prevention methods, early detection, treatment and finding cures.
Proper citation: Karmanos Cancer Institute (RRID:SCR_000508) Copy
The National Bioscience Database Center (NBDC) intends to integrate all databases for life sciences in Japan, by linking each database with expediency to maximize convenience and make the entire system more user-friendly. We aim to focus our attention on the needs of the users of these databases who have all too often been neglected in the past, rather than the needs of the people tasked with the creation of databases. It is important to note that we will continue to honor the independent integrity of each database that will contribute to our endeavor, as we are fully aware that each database was originally crafted for specific purposes and divergent goals. Services: * Database Catalog - A catalog of life science related databases constructed in Japan that are also available in English. Information such as URL, status of the database site (active vs. inactive), database provider, type of data and subjects of the study are contained for each database record. * Life Science Database Cross Search - A service for simultaneous searching across scattered life-science databases, ranging from molecular data to patents and literature. * Life Science Database Archive - maintains and stores the datasets generated by life scientists in Japan in a long-term and stable state as national public goods. The Archive makes it easier for many people to search datasets by metadata in a unified format, and to access and download the datasets with clear terms of use. * Taxonomy Icon - A collection of icons (illustrations) of biological species that is free to use and distribute. There are more than 200 icons of various species including Bacteria, Fungi, Protista, Plantae and Animalia. * GenLibi (Gene Linker to bibliography) - an integrated database of human, mouse and rat genes that includes automatically integrated gene, protein, polymorphism, pathway, phenotype, ortholog/protein sequence information, and manually curated gene function and gene-related or co-occurred Disease/Phenotype and bibliography information. * Allie - A search service for abbreviations and long forms utilized in life sciences. It provides a solution to the issue that many abbreviations are used in the literature, and polysemous or synonymous abbreviations appear frequently, making it difficult to read and understand scientific papers that are not relevant to the reader's expertise. * inMeXes - A search service for English expressions (multiple words) that appear no less than 10 times in PubMed/MEDLINE titles or abstracts. In addition, you can easily access the sentences where the expression was used or other related information by clicking one of the search results. * HOWDY - (Human Organized Whole genome Database) is a database system for retrieving human genome information from 14 public databases by using official symbols and aliases. The information is daily updated by extracting data automatically from the genetic databases and shown with all data having the identifiers in common and linking to one another. * MDeR (the MetaData Element Repository in life sciences) - a web-based tool designed to let you search, compare and view Data Elements. MDeR is based on the ISO/IEC 11179 Part3 (Registry metamodel and basic attributes). * Human Genome Variation Database - A database for accumulating all kinds of human genome variations detected by various experimental techniques. * MEDALS - A portal site that provides information about databases, analysis tools, and the relevant projects, that were conducted with the financial support from the Ministry of Economy, Trade and Industry of Japan.
Proper citation: NBDC - National Bioscience Database Center (RRID:SCR_000814) Copy
http://www.jsps.go.jp/english/
Research and outreach organization dedicated to promoting science, research and education. The society has four main objectives, including building international cooperative networks, enhancing education and research at universities, building evidence-based science-promotion systems and creating diverse world level knowledge.
Proper citation: Japan Society for the Promotion of Science (RRID:SCR_001085) Copy
http://www.nationalacademies.org/nrc/
Private, non-profit institution dedicated to utilizing knowledge in science, engineering, technology and health to improve government decision making and public policy as well as increase public education and understanding. The council collects, analyzes and shares information and knowledge through activities such as consensus studies, meetings and workshops, and program and research management.
Proper citation: National Research Council (RRID:SCR_000446) Copy
http://neuroscience.berkeley.edu/
Portal for UC Berkeley's neuroscience research center. The group focuses on interdisciplinary collaboration between neuroscientists and members of UC Berkeley programs in engineering, chemistry, statistics, and computation. It also runs the neuroscience PhD program.
Proper citation: Helen Wills Neuroscience Institute (RRID:SCR_001991) Copy
The Centre for Vision Research focuses on interdisciplinary research into human and machine vision and visual processes, into vision's interactions with other senses and with motor and cognitive processes, and in applications such as visually-guided robotics or clinical diagnosis and treatment. The Centre for Vision Research includes the following major research themes: - Human Visual Performance - Visual Human-Computer Interaction, Graphics and Virtual Reality - Visual Psychophysics - Eye Movements and Hand-Eye Coordination - Computational Modeling and Computer Vision - Electrophysiology - Clinical and Developmental Studies - Brain Imaging
Proper citation: Centre for Vision Research (RRID:SCR_002879) Copy
http://www.scrm.uzh.ch/biobank.html
The SCRM-CTBB offers state-of-the-art infrastructure and technologies (e.g. cryogenic work bench, semiautomatic cryogenic storage system, uninterrupted cooling chain) and is structured into two areas, including research and a GMP/GCP regulated therapeutic applications. Research: For pre-clinical studies, the SCRM-CTBB provides researchers guidance regarding cell and tissue cryo-preservation, comprising registration, handling, storage and distribution. In order to ensure complete traceability on samples and belonging information all processes are controlled by a Laboratory Information Management System (LIMS) and Quality Assurance (QA) system. The SCRM Biobank is designed to create database that allows connection with other biobanks nationally and internationally. This meta-data file will enable a unique scientific resource for interdisciplinary research. For every new study a contract is established describing the study and the disposition rights. Assistance in writing Biobank Agreements (BAs) and Material Transfer Agreements (MTAs) is provided. Therapeutical applications: As a new feature, apart from research, the SCRM Biobank enables the asservation and preservation of cells and tissues under GMP conditions for later therapeutic use. A special focus will be on a conceptional combination of private and public umbilical cord blood banking (hybrid banking), which allows autologous and/or allogeneic cell applications.
Proper citation: University of Zurich SCRM - Cell-and Tissue Biobank (RRID:SCR_004959) Copy
With expertise in the preservation of biological specimens, Swiss Biobank is a biobank of cell therapy products (stem cells, progenitor). Strategically located in Suisse Romande, the center is accessible 7J/7J, 365 days / year. The laboratories and technology platforms are tailored to international standards. Service is prompt, courteous, and responsive to your needs. The first opportunity to harvest adult stem cells, which is the only type at Swiss Biobank, occurs just after the birth of a baby. The umbilical cord blood and placenta are rich in hematopoietic stem cells and can regenerate all cells in the bloodstream. The cord and placenta tissues themselves contain mesenchymal cells that can be used for the regeneration of connective tissue. The standardized procedures for collecting cord blood units are made ����??����??by the medical staff of the hospital / clinic according to international standards. The sample is transported by a courier Swiss Medical Biobank in which it is prepared and cryo-preserved by qualified personnel within 24 hours. In the case of public biobanking, cells, tissues, organs are donated and can be used with consent of the donor, a third person for transplantation, or as part of clinical research. The HLA (Human Leukocyte Antigen) is a group of proteins on the cell surface, and specific to each individual. This allows the immune system to distinguish our own cells for foreign elements (pathogens) that are likely to be attacked. Histocompatibility between the donor and recipient is of primary importance in organ transplantation, tissues and / or cells, to minimize the chances of rejection. There is one chance in four that two siblings have the same HLA code.
Proper citation: Swiss Biobank (RRID:SCR_004516) Copy
http://www.tmf-ev.de/EnglishSite/Home.aspx
As an umbrella organization for medical research networks, the TMF is responsible for improving the organization and infrastructure of medical research in networked structures. It supports researchers at the various locations in jointly identifying and solving problems of an organizational, legal and technical nature that are often not associated with the particular clinical problem or research focus. The network not only focuses on legal and ethical frameworks for networked medical research but also on the development of IT infrastructure, quality management activities for science-initiated trials and questions on the intermeshing of research and patient care. Under the umbrella organization of the TMF, expert opinions, studies, concepts, requirements specifications, services and tools are created. The products of the cooperation within the TMF are available to the research community. The aims of joint work in the TMF are: * Improvement of medical research in terms of quality, organization and cooperation * Solution of questions spanning networked medical research, e.g. on the collection, processing and exchange of research data * Clarification of the legal and ethical foundations for performing medical research * Issues of quality assurance and quality management * Development and extension of efficient IT infrastructures and their implementation in cross-institutional networked structures * Realization of cross-location solutions * Contributions to sustainable and efficient health research by means of the improved transfer of research findings to patient care
Proper citation: TMF (RRID:SCR_004993) Copy
http://nimh-repository.rti.org/
A program that synthesizes, purifies, and distributes otherwise unavailable essential compounds to stimulate basic and clinical research in psychopharmacology relevant to mental health in areas such as the molecular pharmacology and signaling of CNS receptors, longitudinal studies to evaluate the molecular, biochemical, and behavioral actions of psychoactive compounds, and functional brain imaging in both primates and humans. WHAT IS AVAILABLE: * Ligands for CNS receptors, radiolabeled compounds for autoradiography and neuroimaging, biochemical markers, drug analogs and metabolites, and reference standards * Synthesis (including GMP) of promising compounds for mental health research, including preclinical toxicology and safety studies, especially compounds for PET neuroimaging * A listing of currently available NIMH CSDSP compounds is available online at www.nimh-repository.rti.org. RTI International scientists can provide investigators with technical assistance and additional information about the compounds on request. Data sheets containing purity, storage, and handling information are supplied with all NIMH CSDSP compounds. WHO IS ELIGIBLE: Investigators involved in basic or clinical research relevant to mental health are eligible to submit requests. To learn more about current NIMH research areas, please visit the NIMH website at www.nimh.nih.gov. NIMH CSDSP compounds are free to qualified academic investigators, but payment may be required from nonacademic requestors. Investigators interested in obtaining radiolabeled compounds but uncertain about what type of label or specific activity would work best for them may obtain help by communicating with the technical contacts listed on the website.
Proper citation: NIMH Chemical Synthesis and Drug Supply Program (RRID:SCR_004921) Copy
A long-term health research project which follows pregnant women and their offspring in a continuous health and developmental study. More than 14,000 mothers enrolled during pregnancy in 1991 and 1992, and the health and development of their children has been followed in great detail. The ALSPAC families have provided a vast amount of genetic and environmental information over the years which can be made available to researchers globally.
Proper citation: ALSPAC (RRID:SCR_007260) Copy
http://www.ngfn.de/en/start.html
The program of medical genome research is a large-scale biomedical research project which extends the national genome research net (NGFN) and will be funded by the federal ministry of education and research (BMBF) from 2008-2013. Currently the program includes two fields: * Research ** NGFN-Plus: With the aim on combating diseases that are central to health policy, several hundred researchers are systematically investigating the complex molecular interactions of the human body. They are organized in 26 Integrated Genome Research Networks. * Application ** NGFN-Transfer: The rapid transfer of results from medical genome research into medical and industrial application is the aim of the scientists from research institutes and biomedical enterprises that cooperate in eight Innovation Alliances. AREAS OF DISEASE * Cardiovascular disease * Cancer * Neuronal diseases * Infections and Inflammations * Environmental factors
Proper citation: National Genome Research Network (RRID:SCR_006626) Copy
Mimas is an organization of experts. Our role is to support the advancement of knowledge, powering world-class research and teaching. Technology is at the heart of everything we do. As a nationally designated data center, we host a significant number of the UK''s research information assets. But our core expertise is building applications that enable a wide range of users to make the most of this rich resource from students and researchers working with census data to investigate social inequalities, to scientists using satellite imagery to survey and protect our environment. We have a longstanding relationship with JISC, developing services that support teaching, learning and research and strong connections with research councils, especially the Economic and Social Research Council (ESRC). We also have partnerships with commercial groups, universities and colleges, government agencies, and national libraries and archives. * An organization of experts: We''re experts in technological development, information management, user support, training, project management, and applied research. * What we do: We maintain and support quality services, develop applications and software, provide data hosting and storage, and share our learning. * What we stand for: Four main principles guide our activities: commitment to our users, technological experimentation and innovation, communication within our community, and investment in staff.
Proper citation: Mimas (RRID:SCR_006529) Copy
http://www.proquest.com/en-US/
Service that helps users navigate the research journey, connecting people and information from dissertations to governmental and cultural archives to news, in all its forms. Its role is essential to libraries and other organizations whose missions depend on the delivery of complete, trustworthy information. ProQuest''s massive information pool, built through partnerships with content creators, is navigated through technological innovations that enable users to quickly find just the right information. The ProQuest platform moves beyond navigation to empower researchers to use, create, and share contentaccelerating research productivity. The Summon web-scale discovery service is a boon to academic libraries worldwide. ProQuest expanded into corporate and government markets, with the ProQuest Dialog service and acquiring Congressional Information Services and University Publications of America. It acquired ebrary, expanding ProQuest''s content base to include e-books and adding to the technology expertise resident across the enterprise, which also includes such units as Serials Solutions, RefWorks-COS, and Bowker.
Proper citation: ProQuest (RRID:SCR_006093) Copy
A blog presented by Faculty of 1000 highlighting and linking to the latest, greatest research recommended by F1000. Contributors include F1000 staff, freelance journalists, and scientists. We encourage readers to participate in the conversation via email to suggest topics and contribute guest posts.
Proper citation: Naturally Selected (RRID:SCR_006572) Copy
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