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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://text0.mib.man.ac.uk/software/mldic/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 9, 2022. System that retrieves relevant UniProt IDs from BioThesaurus entries using a soft string matching algorithm.
Proper citation: Smart Dictionary Lookup (RRID:SCR_000568) Copy
A stem cell bank in Malaysia which provides and carries out long-term human stem cells and tissue cryopreservation and research. The general public can use their biobanking services for personal use.
Proper citation: CryoCord Stem Cell Bank (RRID:SCR_000329) Copy
http://brainvis.wustl.edu/wiki/index.php/Caret:Atlases
THIS RESOURCE IS NO LONGER IS SERVICE. Documented on July,29,2022. Surface-based atlases of human, macaque, rat and mouse cerebral and cerebellar cortices derived from structural MRI volumes developed in the Van Essen laboratory can be downloaded by direct links on the SumsDB database and can be viewed using freely available Caret (offline) and WebCaret (online) software. The human and macaque atlases include a large and growing compendium of experimental data pertaining to the structural and functional organization of primate cerebral cortex.
Proper citation: Surface-Based Atlases (RRID:SCR_002099) Copy
http://mirna.imbb.forth.gr/SSCprofiler.html
Tool which can be used to identify novel miRNA gene candidates in the human genome.
Proper citation: SSCprofiler (RRID:SCR_001282) Copy
http://www.cabiatl.com/mricro/anatomy/home.html
Annotated magnetic resonance brain images, both slices and surface views, normalized to Talairach space, along with annotations and a nice tutorial on image normalization. A viewer for MRI images (MRicro) is available and is described in a separate entry. Series of coronal, axial and sagittal brain slices along with some rendered volumes with major brain structures delineated. Slices are presented as static series with partial overlap of slices, so they are not suitable for 3d reconstruction. This neuroanatomy atlas shows regions on normalized MRI scans. Normalization is the process of warping a brain to match a standard size, orientation and shape of other brains. You can normalize MRI scans using programs like AIR, FLIRT or SPM. Once normalized, the overall shape of your MRI scan will approximately match those in this atlas. However, normalization preserves the unique sulcal features of each brain, so there will be some variation between your image and the images shown in this atlas. There is a great deal of individual variability even after normalization, so any atlas is only a rough guide to the shape and location of structures in an individuals brain. As I have noted before, secondary and tertiary sulci are not found in all individuals (Ono et al. 1990, Atlas of Cerebral Sulci). Another benefit of normalizing brains is it makes it easy to complete an accurate "scalp stripping" with brain extracting software (my MRIcro software implements Steve Smith's BET for this task). You can then create a useful volume rendering of the cortical surface. Typically, it is much easier to identify cortical sulci and gyri by looking at a rendered image of the brain's surface. This atlas shows you how to recognize these landmarks on a rendered MRI scan.
Proper citation: Neuroanatomy Atlas (RRID:SCR_002402) Copy
http://neurosurgery.ucsf.edu/index.php/research_tissue_bank.html
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 4th,2023. Brain Tumor Research Center Tissue Bank began collecting tissue in 1978 and has established an organized repository of characterized tissues--frozen, paraffin-embedded, blood and cultures--that are maintained in a manner useful for a wide range of studies. Samples are collected only from patients who have agreed to have their tissues banked and used for future research. Consent documents are maintained in a secure area and associated clinical data are held in a double-password protected computer database. Each sample received into the Tissue Bank is non-identifying number. No protected health information (PHI) is released. To obtain samples, investigators submit a request form to the Manager. The request form requires an explanation of the tissue requested (type, number of samples, justification), description of the study, CHR approval (see new policy regarding human vs. non-human research) and Project Leader authorization. The Manager reviews each request for feasibility before presentation to the Scientific Core Committee. The UCSF Neurosurgery Tissue Bank makes its inventory of stock cell lines available to all investigators. Requested cells are grown in T-25 flasks and shipped FedEx Priority Overnight at the receipient's expense. However, if you prefer, we can ship the frozen cells, packed in dry ice. (Note: some countries restrict dry ice shipments.)
Proper citation: UCSF Brain Tumor Tissue Bank (RRID:SCR_000647) Copy
http://www.childrennetwork.org/
Database of clinical information and serum and tissue samples from children across the United States and Canada with Biliary Atresia, Idiopathic Neonatal Hepatitis, Cystic Fibrosis Liver Disease, Alagille Syndrome, Alpha-1 Antitrypsin Deficiency, Bile Acid Synthesis Defects, Mitochondrial Hepatopathies, and Progressive Familial Intrahepatic Cholestasis in order to facilitate research and to perform clinical, epidemiological, and therapeutic trials in these important pediatric liver diseases. Three NIDDK-funded consortia, Biliary Atresia Research Consortium (BARC), Cholestatic Liver Disease Consortium (CLiC), and the Cystic Fibrosis Liver Disease (CFLD) Network were consolidated to form ChiLDREN. Most of the ChiLDREN studies are natural history studies aimed at acquiring information and data that will provide a better understanding of these rare conditions. Participants will be asked to allow study personnel to obtain information from medical records and an interview, and to collect blood, urine, and tissue samples when clinically indicated, in order to understand the causes of these diseases and to improve the diagnosis and treatment of children with these diseases. All of the information obtained in these studies is confidential and no names or identifying information are used in the study.
Proper citation: Childhood Liver Disease Research and Education Network (RRID:SCR_001497) Copy
http://www.som.soton.ac.uk/research/sites/cruk/translation/tumour.asp
Collects and distributes human tissue for ethically approved studies to aid the study of cancer biology and other associated research. All tissue is collected with patient consent and tissue is distributed only to ethically approved studies. The purpose of the Tissue Bank is to source, organize, collect, prepare, store and distribute a diverse collection of human tissues and biological products. This valuable core resource is available to all local academics and researchers. The on-site bank allows for rapid access to a plethora of biological materials supported by an informatics system of databases acting as an inventory management system. In addition, the Tissue Bank provides a licensed facility to store surplus tissue when studies close. Tissues currently available include normal and malignant snap frozen blocks, freshly prepared spleen and lymph nodes, fresh biopsy tissues, blood products and biological fluids. Collections can be organized by bank staff or ran in parallel with current research activities and include a wide variety of cancer classifications. We currently hold over 38,000 vials. Tissue Availability: Lymphoma - solid tissue and cells - 843; Breast - solid tissue and cells - 540; Colon - solid tissue and cells - 238; Lung - solid tissue and cells - 43; Upper Gi - BIOPSY tissue - 114; Pleural fluid and cells - 14
Proper citation: Southampton Tumour Bank (RRID:SCR_000673) Copy
http://bioinf.scri.sari.ac.uk/cgi-bin/atnopdb/home
Database of proteins found in the nucleoli of Arabidopsis, identified through proteomic analysis. The Arabidopsis Nucleolar Protein database (AtNoPDB) provides information on the plant proteins in comparison to human and yeast proteins, and images of cellular localizations for over a third of the proteins. A proteomic analysis was carried out of nucleoli purified from Arabidopsis cell cultures and to date 217 proteins have been identified. Many proteins were known nucleolar proteins or proteins involved in ribosome biogenesis. Some proteins, such as spliceosomal and snRNP proteins, and translation factors, were unexpected. In addition, proteins of unknown function which were either plant-specific or conserved between human and plant, and proteins with differential localizations were identified.
Proper citation: Arabidopsis Nucleolar Protein Database (RRID:SCR_001793) Copy
A platform composed of three modules: the Database, the Search Engine, and rSNPs, for the computational identification of transcription factor binding sites (TFBSs) in multiple genomes, that combines TRANSFAC and JASPAR data with the search power of profile hidden Markov models (HMMs). The Database contains putative TFBSs found in the upstream sequences of genes from the human, mouse and D.melanogaster genomes. For each gene, they scanned the region from 10,000 base pairs upstream of the transcript start to 50 base pairs downstream of the coding sequence start against all their models. Therefore, the database contains putative binding sites in the gene promoter and in the initial introns and non-coding exons. Information displayed for each putative binding site includes the transcription factor name, its position (absolute on the chromosome, or relative to the gene), the score of the prediction, and the region of the gene the site belongs to. If the selected gene has homologs in any of the other two organisms, the program optionally displays the putative TFBSs in the homologs. The Search Engine allows the identification, visualization and selection of putative TFBSs occurring in the promoter or other regions of a gene from the human, mouse, D.melanogaster, C.elegans or S.cerevisiae genomes. In addition, it allows the user to upload a sequence to query and to build a model by supplying a multiple sequence alignment of binding sites for a transcription factor of interest. rSNPs MAPPER is designed to identify Single Nucleotide Polymorphisms (SNPs) that may have an effect on the presence of one or more TFBSs.
Proper citation: MAPPER - Multi-genome Analysis of Positions and Patterns of Elements of Regulation (RRID:SCR_003077) Copy
The EuroBioBank network is the first operating network of biobanks in Europe providing human DNA, cell and tissue samples as a service to the scientific community conducting research on rare diseases. It is the only network dedicated to rare disease research in Europe. By creating a critical mass of collections and facilitating the exchange of biological material, the EuroBioBank network helps accelerate research on these diseases. * Over 440,000 samples are available across the network and can be requested via the online catalogue. Approximately 13,000 samples are collected each year and 7,000 samples distributed in Europe and beyond. The biological samples are obtained from patients affected by rare diseases, including rare neuromuscular disorders. * The EuroBioBank Network is currently composed of 18 members, of which 16 biobanks from 8 European countries (France, Germany, Hungary, Italy, Malta, Slovenia, Spain and the United-Kingdom) as well as Israel and Canada. Goals * Identify and localize biological material of interest to researchers * Build a critical mass of rare disease sample collections * Distribute high quality material and associated data to users * Promote best-practice guidelines for biobanking activities * Disseminate knowledge and know-how to the scientific community through training courses * Enhance collaboration with the medical and scientific community in the field of rare diseases EuroBioBank acts as a clearing house or virtual bank, with all samples listed in the central online catalogue remaining in the possession of the member biobanks, where they are located and can be requested. The network was established by patients and researchers to facilitate research on rare diseases by guaranteeing quick and easy access to samples via an online catalogue. The catalogue lists the samples available throughout the EuroBioBank network by type of biomaterial. A search engine enables a search by disease or by bank contact. Once a sample has been located in the catalogue, it can be requested by email. Therefore, the biological material is exchanged faster. If a sample does not appear in the EuroBioBank catalogue, help can be provided to further search it at: eurobiobank (at) telethon.it Funding and Collaboration Originally funded by the EC between 2003-2006, the EuroBioBank received further EC support between 2007-2011 within the European Network of Excellence TREAT-NMD (FP6), which covered the cost sustained by Eurordis for the network coordination and website hosting. Each biobank of the network is financed by its own Institution or charitable organization. As of January 2012, the Fondazione Telethon provides the administrative support for coordinating the EuroBioBank network and hosting the website.
Proper citation: EuroBioBank (RRID:SCR_003599) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 9, 2023. In this web site you will find the central European database of OECI-TuBaFrost collecting the information of biobanks or in the project support environment on human material; i.e., frozen tumor tissue specimens, pathology blocks, blood samples in different forms, cell lines, Tissue Micro Arrays, etc. Our goal is by centralizing the tumor tissues information to facilitate the search of doctors / researchers for tumor materials, which they need for their cancer research there with facilitating cancer research. OECI members only can participate in the OECI-TuBaFrost exchange platform, or those introduced by an OECI member. We are a group of pathology and research departments as well as bio-bankers in clinical based biobanking based in comprehensive cancer centers or hospitals with a competence in comprehensive cancer care across Europe. Each participating institute is involved in cancer research resulting in innovative procedures, new drugs, improved diagnosis and new insights in disease development. The overall result is better care and treatment for cancer patients. To maximize the scientific value of the human tissue samples, information about the clinical status of the patient in combination with the quality and type of samples is very important. A TuBaFrost electronic database will securely store all this information. Within the closed project supporting environments, the data collected will include: * Diagnosis - identification of the type of cancer * Type of tissue collected - the origin, i.e. breast, skin, colorectal * Quality of tissue collected - collection and storage details The tissue is stored in the hospital where the donor was diagnosed/treated. It stays there until it is used or sent to another hospital or research center within the TuBaFrost group. The electronic database will track samples throughout the network. The tissue is not sold. The exchange of tissue to other hospitals is regulated by a contract, which uses the national regulations of the country supplying the tissue. Tissue samples within the TuBaFrost collection will only be used for research, which has been approved by ethics committees. This ensures that the tissue is only used for the best quality research and only for the specific reasons given to the ethics committee.
Proper citation: OECI - Tubafrost: The European Human Frozen Tissue Bank (RRID:SCR_004280) Copy
http://www.uclaaidsinstitute.org/researchareas/clinical_nnab.php
THIS RESOURCE IS NO LONGER IN SERVICE, documented on March 23, 2012. The National Neurologic AIDS Bank (NNAB) is a site of the HIV/CNS Tissue Network. Based in Los Angeles, which has the largest and most diverse AIDS population in the western United States, the NNAB provides researchers with well-characterized neural tissue from HIV-1-infected and seronegative control donors. The NNAB collaborates with the other designated sites, funding agencies, and outside experts to develop local and national tissue networks. There are plans to create a Network Steering Committee, a panel of outside advisers, and a protocol to recruit and characterize human donors. The NNAB collects pre- and post-mortem clinical data and neural tissues using a standardized autopsy protocol, and the bank stores, codes, catalogs, and distributes this tissue. An electronic database and an Internet-based application process that researchers can use to access the Network's resources are being designed.
Proper citation: National Neurological AIDS Bank (RRID:SCR_003583) Copy
http://www.masy.com/biopharma-repository/biopharma-repository
Safe and secure environmentally controlled storage for the biotech, pharmaceutical and medical device industries. Masy provides same-day retrieval and shipping of your biomaterials. Our cost-effective repository space is comprised of multiple chamber styles, from walk-in refrigerators / freezers for large containers, to single-shelf storage units for individual vials. Segregated & unsegregated storage is available. Our sophisticated inventory management system utilizes a precise bar-code inventory track-and-trace system with data safely stored on dedicated servers. Critical data access is secured by password protection. Environmental storage condition information and sample access is limited to customer approved personnel only. Our in-house Validation and Calibration teams allow us to offer unique storage conditions. And, we now offer GMP labeling and distribution of clinical samples. Masy is ISO 9001:2009 Certified and NVLAP ISO/IEC 17025:2005 Accredited. Our state-of-the-art facility is conveniently located less than an hour from Metro-Boston, just 15 minutes from the Devens Commerce Park.
Proper citation: BioPharma Storage Facility - Masy Systems (RRID:SCR_004155) Copy
Nevada Donor Network (NDN) is a federally designated, not-for-profit organ, tissue, and eye procurement organization. NDN is responsible for the coordination, recovery, and distribution of donated human organs and tissues for transplantation and medical research throughout the Las Vegas area. In addition, NDN participates in national organ and tissue sharing in an effort to meet the ever-growing needs of patients awaiting transplantation therapy. NDN is one of the few organ procurement agencies in the country to manage the recovery of organs, tissues, and eyes in the same facility, making Nevada progressive in the field of organ and tissue procurement. NDN is certified by the Department of Health and Human Services and the Center for Medicare and Medicaid Services (CMS). The Network is accredited by the Eye Bank Association of America (EBAA), the American Society for Histocompatibility and Immunogenetics (ASHI), the Clinical Laboratory Improvement Act (CLIA), and the American Association of Tissue Banks (AATB).
Proper citation: Nevada Donor Network, Inc. (RRID:SCR_004276) Copy
http://www.southtexasblood.org/
A non-profit, community resource that works with volunteer donors to provide the highest quality blood and tissue components to patients. They collect and test more than 200,000 components of life-saving blood and tissue each year from volunteers all over South Texas. Because patients are in constant need of blood, blood components, and/or tissue, donors are essential. By using cutting-edge technology, the team of dedicated professionals have helped save hundreds of thousands of lives over more than 35 years. They are a member of the American Association of Blood Banks (AABB); American Association of Tissue Banks (AATB) and America''s Blood Centers (ABC). We are also one of the first blood centers in the country to be registered by the International Standards Organization.
Proper citation: South Texas Blood and Tissue Center (RRID:SCR_004272) Copy
New Life Generation is a not-for-profit tissue agency headquartered in Indianapolis, Indiana. We recognize our responsibility to recover, process, store and distribute human tissues in a professional manner that is of service to the medical community, ensures safety of transplantable tissue, and increases the availability of quality allograft tissue. While our primary focus is tissue donation, we recognize that donation also includes organ, bone marrow, blood, and blood products.
Proper citation: New Life Generation, Inc. (RRID:SCR_004273) Copy
http://www.utsouthwestern.edu/utsw/home/research/transplantsvcs/
Transplant Services Center is a clinical and academic service center of UT Southwestern Medical Center which completes the Circle of Care from donation to transplantation by providing a full service tissue bank which procures, processes, stores and distributes tissue allografts. These transplantable tissues include corneas, sclera, skin, musculoskeletal and cardiovascular allografts, which restore function, improve the quality of life and in some cases even save lives. Transplant Services Center provides services to hospitals and physicians throughout Texas, the nation and on occasion worldwide. The mission of the Transplant Services Center is to * provide quality tissue grafts for transplantation, teaching, research and medical need that is responsive and appropriate to both the recipient need and the donor family; * to promote public and professional education to increase donor awareness; * and to contribute to advancements in transplantation technology.
Proper citation: Transplant Services Center (RRID:SCR_004274) Copy
http://www.ncbi.nlm.nih.gov/homologene
Automated system for constructing putative homology groups from complete gene sets of wide range of eukaryotic species. Databse that provides system for automatic detection of homologs, including paralogs and orthologs, among annotated genes of sequenced eukaryotic genomes. HomoloGene processing uses proteins from input organisms to compare and sequence homologs, mapping back to corresponding DNA sequences. Reports include homology and phenotype information drawn from Online Mendelian Inheritance in Man, Mouse Genome Informatics, Zebrafish Information Network, Saccharomyces Genome Database and FlyBase.
Proper citation: HomoloGene (RRID:SCR_002924) Copy
http://www.biocomputing.it/fidea/
A web server for the functional interpretation of differential expression analysis. It can: * Calculate overrepresentation statistics using KEGG, Interpro, Gene Ontology Molecular Function, Gene Ontology Biological Process, Gene Ontology Cellular Component and GoSlim classifications; * Analyze down-regulated and up-regulated DE genes separately or together as a single set; * Provide interactive graphs and tables that can be modified on the fly according to user defined parameters; the user can set a fold change filter and interactively see the effects on the gene set under examination; * Output publication-ready plot of the graph; * Compare the results of several experiments in any combination.
Proper citation: FIDEA (RRID:SCR_004187) Copy
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