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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
CEM
 
Resource Report
Resource Website
1+ mentions
CEM (RRID:SCR_013241) CEM software resource An algorithm to assemble transcripts and estimate their expression levels from RNA-Seq reads. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of California at Riverside; California; USA
OMICS_01271, biotools:cem https://bio.tools/cem SCR_013241 CEM: Transcriptome Assembly and Isoform Expression Level Estimation from Biased RNA-Seq Reads 2026-09-12 12:58:00 1
BEADS
 
Resource Report
Resource Website
10+ mentions
BEADS (RRID:SCR_013229) BEADS software resource Software for a normalization scheme that corrects nucleotide composition bias, mappability variations and differential local DNA structural effects in deep sequencing data. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
has parent organization: University of Cambridge; Cambridge; United Kingdom
PMID:21646344 OMICS_00466, biotools:beads https://bio.tools/beads SCR_013229 BEADS: Bias Elimination Algorithm for Deep Sequencing, Bias Elimination Algorithm for Deep Sequencing 2026-09-12 12:58:00 38
Trans-ABySS
 
Resource Report
Resource Website
50+ mentions
Trans-ABySS (RRID:SCR_013322) Trans-ABySS software resource A software pipeline for analyzing ABySS-assembled contigs from shotgun transcriptome data. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
OMICS_01326, biotools:trans-abyss https://bio.tools/trans-abyss/ SCR_013322 2026-09-12 12:58:02 72
Dali Server
 
Resource Report
Resource Website
500+ mentions
Dali Server (RRID:SCR_013433) analysis service resource, data analysis service, production service resource, service resource, software resource Network service for comparing protein structures in 3D. You submit the coordinates of a query protein structure and Dali compares them against those in the Protein Data Bank (PDB). You receive an email notification when the search has finished. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. Requests can also be submitted by e-mail to dali-server at helsinki dot fi. The body of the e-mail message must contain atomic coordinates in PDB format. If you want to know the structural neighbours of a protein already in the Protein Data Bank (PDB), you can find them in the Dali Database. If you want to superimpose two particular structures, you can do it in the pairwise DaliLite server. Academic users may download the DaliLite program for local use. Protein structure comparison server, protein structure, comparison server, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
has parent organization: University of Helsinki; Helsinki; Finland
PMID:20457744 Free, Freely available biotools:dali https://bio.tools/dali SCR_013433 Dali 2026-09-12 12:58:03 534
ENIGMA
 
Resource Report
Resource Website
100+ mentions
ENIGMA (RRID:SCR_013400) data analysis software, data processing software, software application, software resource A software tool to extract gene expression modules from perturbational microarray data, based on the use of combinatorial statistics and graph-based clustering. The modules are further characterized by incorporating other data types, e.g. GO annotation, protein interactions and transcription factor binding information, and by suggesting regulators that might have an effect on the expression of (some of) the genes in the module. Version : ENIGMA 1.1 used GO annotation version : Aug 29th 2007 genome, gene, genetic software, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Ghent University; Ghent; Belgium
is parent organization of: ENIGMA-DTI Pipeline
PMID:18402676 biotools:enigma, nlx_144365 https://bio.tools/enigma SCR_013400 2026-09-12 12:58:02 133
Pairwise Conservation Scores - An Algorithm to Identify Conserved K-mers
 
Resource Report
Resource Website
1+ mentions
Pairwise Conservation Scores - An Algorithm to Identify Conserved K-mers (RRID:SCR_013409) PCS software resource A stand-alone package to identify and analyze conserved k-mers in pairwise alignment. This program shows high performance for identifying miRNA seed binding sites in 3''-UTRs. perl, perl script, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Tsinghua University; Beijing; China
biotools:pcs, nlx_33020 https://bio.tools/pcs http://bioinfo.au.tsinghua.edu.cn/member/~gujin/pcs/ SCR_013409 Pairwise Conservation Scores 2026-09-12 12:58:03 3
CNV-seq
 
Resource Report
Resource Website
100+ mentions
CNV-seq (RRID:SCR_013357) CNV-seq software resource A method for detecting DNA copy number variation (CNV) using high-throughput sequencing., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
THIS RESOURCE IS NO LONGER IN SERVICE biotools:cnv-seq, OMICS_00339 https://bio.tools/cnv-seq SCR_013357 2026-09-12 12:58:02 167
COPASI
 
Resource Report
Resource Website
100+ mentions
COPASI (RRID:SCR_014260) COPASI data analysis software, data processing software, simulation software, software application, software resource, standalone software Software application for simulation and analysis of biochemical network models and their dynamics. COPASI supports models in the SBML standard and can simulate their behavior using ODEs or Gillespies stochastic simulation algorithm. Arbitrary discrete events can be included in such simulations. Models in COPASI are based on reactions that convert a set of species into another set of species. Simulation can be performed either with stochastic kinetics or with differential equations. COPASI also includes various methods of analysis and data visualization. standalone software, simulation software, data analysis, biochemical system simulator, biochemical network model, biochemical network dynamics, bio.tools is listed by: Debian
is listed by: bio.tools
DOI:10.1093/bioinformatics/btl485 Free, Available for download, Acknowledgement requested biotools:copasi https://bio.tools/copasi SCR_014260 COPASI: Biochemical System Simulator 2026-09-12 12:58:14 445
CYANA
 
Resource Report
Resource Website
100+ mentions
CYANA (RRID:SCR_014229) data analysis software, data processing software, software application, software resource Software for automated structure calculation of biological macromolecules on basis of conformational constraints from nuclear magnetic resonance. Program for automated NMR protein structure calculation. CYANA requires a sufficient list of assigned chemical shifts and lists of cross-peak positions and columns from 2D, 3D, or4D NOESY spectra in order to calculate the assignment of the NOESY cross-peaks and the 3D structure of the protein in solution. protein structure, nmr, noesy, 3d structure, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Goethe University Frankfurt am Main; Hessen; Germany
has parent organization: RIKEN
PMID:15318003
PMID:25801209
Available to the academic community, Available to commercial user, Pay for license SCR_021949, biotools:cyana http://www.las.jp/english/products/cyana.html, https://bio.tools/cyana, https://dbpedia.org/page/CYANA_(software) SCR_014229 2026-09-12 12:58:14 428
Coot
 
Resource Report
Resource Website
10000+ mentions
Coot (RRID:SCR_014222) COOT data or information resource, model, simulation software, software application, software resource, software toolkit Software for macromolecular model building, model completion and validation, and protein modelling using X-ray data. Coot displays maps and models and allows model manipulations such as idealization, rigid-body fitting, ligand search, Ramachandran plots, non-crystallographic symmetry and more. Source code is available. software toolkit, simulation software, model manipulation, protein modeling, bio.tools is used by: PDB-REDO
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
is related to: MolProbity
has parent organization: MRC Laboratory of Molecular Biology
PMID:15572765 Available for download, Acknowledgement requested biotools:coot http://strucbio.biologie.uni-konstanz.de/ccp4wiki/index.php/Coot, https://bio.tools/coot SCR_014222 Crystallographic Object-Oriented Toolkit 2026-09-12 12:58:14 15682
SHELX
 
Resource Report
Resource Website
500+ mentions
SHELX (RRID:SCR_014220) data processing software, image analysis software, image reconstruction software, software application, software resource, standalone software A set of software programs that utilizes dual spaces algorithms for the determination of small and macromolecular crystal structures by single crystal X-ray and neutron diffraction. Libraries, extra files and environment variables are not required for the executables. SHELX is intended to be run on a command prompt but may be called from GUIs such as shelXle, Olex2, Oscail or WinGX, or hkl2map., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. standalone software, image reconstruction software, image analysis software, crystal structure, crystal xray, neutron diffraction, bio.tools is listed by: bio.tools
is listed by: Debian
DOI:10.1107/S2053273314026370 THIS RESOURCE IS NO LONGER IN SERVICE biotools:shelx https://bio.tools/shelx SCR_014220 2026-09-12 12:58:13 523
Crystallography and NMR System (CNS)
 
Resource Report
Resource Website
1+ mentions
Crystallography and NMR System (CNS) (RRID:SCR_014223) CNS data processing software, data visualization software, software application, software resource, software toolkit Software designed to provide a multi-level hierachical approach for the most commonly used algorithms in macromolecular structure determination. Features include heavy atom searching, experimental phasing (including MAD and MIR), density modification, crystallographic refinement with maximum likelihood targets, and NMR structure calculation using NOEs, J-coupling, chemical shift, and dipolar coupling data. Modules, libraries, utility programs, tutorials, and a syntax manual are available on the website. structure determination, software suite, macromolecular structure determination, data visualization software, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Yale University; Connecticut; USA
PMID:9757107 Available to academic institutions, Request form must be submitted biotools:cnssolve https://bio.tools/cnssolve SCR_014223 Crystallography and NMR System 2026-09-12 12:58:14 8
PsyGeNET
 
Resource Report
Resource Website
10+ mentions
PsyGeNET (RRID:SCR_014406) data analysis software, data or information resource, data processing software, database, software application, software resource Knowledge platform on psychiatric disorders and their genes. Resource for exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of database and set of analysis tools and is the result of the integration of information from DisGeNET and data extracted from the literature by text mining, followed by curation by domain experts. psychiatric disease, associated gene, database, analysis tool, bio.tools is used by: DisGeNET
is listed by: Debian
is listed by: bio.tools
Psychiatric disorder DOI:10.1093/bioinformatics/btv301 Available for the research community biotools:psygenet2r https://bio.tools/psygenet2r SCR_014406 Psychiatric disorders Gene association NETwork, Psychiatric disorders Gene association Network 2026-09-12 12:58:16 11
SCRATCH
 
Resource Report
Resource Website
100+ mentions
SCRATCH (RRID:SCR_014291) analysis service resource, data access protocol, production service resource, service resource, software resource, web service Web protein structure and structural feature prediction server.Software suite includes predictors for secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts and tertiary structure. User provides amino acid sequence and selects desired predictions, then submits to the server. Protein predictor, secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts, tertiary structure prediction, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:15980571 Free, Freely available biotools:scratch https://bio.tools/scratch http://www.igb.uci.edu/servers/psss.html SCR_014291 Scratch Protein Predictor 2026-09-12 12:58:15 141
NNcon
 
Resource Report
Resource Website
1+ mentions
NNcon (RRID:SCR_014292) prediction, software tool Protein contact map prediction is useful for protein folding rate prediction, model selection and 3D structure prediction. Here we describe NNcon, a fast and reliable contact map prediction server and software. NNcon was ranked among the most accurate residue contact predictors in the Eighth Critical Assessment of Techniques for Protein Structure Prediction (CASP8), 2008. text mining objective, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:19420062 biotools:nncon https://bio.tools/nncon http://casp.rnet.missouri.edu/nncon.html SCR_014292 2026-09-12 12:58:15 2
RepeatScout
 
Resource Report
Resource Website
500+ mentions
RepeatScout (RRID:SCR_014653) algorithm resource, data analysis software, data processing software, sequence analysis software, software application, software resource Algorithm used to identify de novo repeat families in newly sequenced genomes. Repeat libraries for C. briggsae, M. muscles (X chromosome), R. novegicus (X chromosome), armadillo, H. sapiens (X chromosome), and various other mammals created using RepeatScout are available on the main site., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. algorithm, sequence analysis, repeat, genome sequence, de novo, repeat family, repeat library, bio.tools is used by: RepeatModeler
is listed by: Debian
is listed by: bio.tools
has parent organization: University of California at San Diego; California; USA
PMID:15961478 THIS RESOURCE IS NO LONGER IN SERVICE BioTools:RepeatScout, biotools:RepeatScout https://bio.tools/RepeatScout, https://bio.tools/RepeatScout, https://bio.tools/RepeatScout SCR_014653 2026-09-12 12:58:20 818
I-TASSER
 
Resource Report
Resource Website
1000+ mentions
I-TASSER (RRID:SCR_014627) data analysis software, data processing software, software application, software resource Web server as integrated platform for automated protein structure and function prediction. Used for protein 3D structure prediction. Resource for automated protein structure prediction and structure-based function annotation. Automated prediction, protein structure prediction, protein function prediction, protein 3D structure, amino acid sequence, alignment, simulation, 3D atomic model, protein, bio.tools is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
has parent organization: University of Michigan; Ann Arbor; USA
has parent organization: University of Kansas; Kansas; USA
NIGMS GM083107;
NIGMS GM084222
DOI:10.1186/1471-2105-9-40
DOI:10.1093/nar/gkv342
PMID:20360767
PMID:18215316
Free, Available for download, Freely available biotools:i-tasser, SCR_018803 https://bio.tools/i-tasser SCR_014627 Iterative Threading Assembly Refinement, Iterative Threading ASSEmbly Refinement 2026-09-12 12:58:19 3874
Cufflinks
 
Resource Report
Resource Website
5000+ mentions
Cufflinks (RRID:SCR_014597) data analysis software, data processing software, sequence analysis software, software application, software resource Software tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality. transcriptome, rna-seq, rna seq, cuffmerge, cufflink, cuffcompare, transfrags, artifacts, gtf file, transcriptome assembly, expression analysis, bio.tools, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
is listed by: SoftCite
works with: GeneScissors
is hosted by: GitHub
DOI:10.1038/nbt.1621 Acknowledgement requested, Source code available on GitHub biotools:cufflinks, OMICS_01304, SCR_013307 https://github.com/cole-trapnell-lab/cufflinks, https://bio.tools/cufflinks, https://sources.debian.org/src/cufflinks/ SCR_014597 2026-09-12 12:58:19 9083
RAST Server
 
Resource Report
Resource Website
1000+ mentions
RAST Server (RRID:SCR_014606) RAST production service resource, service resource A SEED-quality automated service that annotates complete or nearly complete bacterial and archaeal genomes across the entire phylogenetic tree. RAST can also be used to analyze draft genomes. microbiome, seed, annotate, genome, bacteria, archaea, service, bio.tools is listed by: Human Microbiome Project
is listed by: Debian
is listed by: bio.tools
National Science Foundation 0850546;
NIAID contract HHSN272200900040C
PMID:18261238 Free for the scientific community, Login required biotools:theseed https://bio.tools/theseed SCR_014606 Rapid Annotation using Subsystem Technology, Rapid Annotation using Subsystem Technology Server 2026-09-12 12:58:19 1198
Prokka
 
Resource Report
Resource Website
1000+ mentions
Prokka (RRID:SCR_014732) data analysis software, data processing software, sequence analysis software, software application, software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software tool for the rapid annotation of prokaryotic genomes. It produces GFF3, GBK and SQN files that are ready for editing in Sequin and ultimately submitted to Genbank/DDJB/ENA. A typical 4 Mbp genome can be fully annotated in less than 10 minutes on a quad-core computer, and scales well to 32 core SMP systems., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. annotation, prokaryote, genome, prokaryotic genome, sequence analysis software, annotation software, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
DOI:10.1093/bioinformatics/btu153 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_04220, biotools:prokka https://bio.tools/prokka, https://sources.debian.org/src/prokka/, https://sources.debian.org/src/prokka/ SCR_014732 2026-09-12 12:58:21 4882

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