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http://www.mattmahoney.net/dc/fastqz/

Source code used to compress FASTQ files. FASTQ is DNA sequencing machine output.

Proper citation: fastqz (RRID:SCR_001006) Copy   

•   Source: SciCrunch Registry

http://hihg.med.miami.edu/software-download/seqem-version-1.0

Online tool for utilizing a genotype calling algorithm for next-generation sequence data.

Proper citation: SeqEM (RRID:SCR_002021) Copy   

•   Source: SciCrunch Registry

http://www.refgenes.org/rg/

Tool for the identification of reliable and condition specific reference genes for RT-qPCR data normalization. RefGenes is available within Genevestigator.

Proper citation: RefGenes (RRID:SCR_003372) Copy   

•   Source: SciCrunch Registry

https://github.com/jts/sga

Software package that functions as a de novo genome assembler based on the concept of string graphs. It is designed as a modular set of programs used to assemble large genomes from high coverage short read data.

Proper citation: SGA (RRID:SCR_001982) Copy   

•   Source: SciCrunch Registry

http://www.mged.org/Workgroups/MAGE/mage.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 27,2023. Group providing a standard for the representation of microarray expression data that would facilitate the exchange of microarray information between different data systems.

Proper citation: MAGE (RRID:SCR_002313) Copy   

•   Source: SciCrunch Registry

http://sak042.github.io/Wessim/

Software simulator for a targeted resequencing generally known as exome sequencing. Wessim generates a set of artificial DNA fragments for next generation sequencing (NGS) read simulation.

Proper citation: Wessim (RRID:SCR_002567) Copy   

•   Source: SciCrunch Registry

http://blocks.fhcrc.org/blocks/codehop.html

This COnsensus-DEgenerate Hybrid Oligonucleotide Primer (CODEHOP) strategy has been implemented as a computer program that is accessible over the World-Wide Web and is directly linked from the BlockMaker multiple sequence alignment site for hybrid primer prediction beginning with a set of related protein sequences. This is a new primer design strategy for PCR amplification of unknown targets that are related to multiply-aligned protein sequences. Each primer consists of a short 3' degenerate core region and a longer 5' consensus clamp region. Only 3-4 highly conserved amino acid residues are necessary for design of the core, which is stabilized by the clamp during annealing to template molecules. During later rounds of amplification, the non-degenerate clamp permits stable annealing to product molecules. The researchers demonstrate the practical utility of this hybrid primer method by detection of diverse reverse transcriptase-like genes in a human genome, and by detection of C5 DNA methyltransferase homologs in various plant DNAs. In each case, amplified products were sufficiently pure to be cloned without gel fractionation. Sponsors: This work was supported in part by a grant from the M. J. Murdock Charitable Trust and by a grant from NIH. S. P. is a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 15,2026.

Proper citation: COnsensus-DEgenerate Hybride Oligonucleotide Primers (RRID:SCR_002875) Copy   

•   Source: SciCrunch Registry

http://research-pub.gene.com/gmap/

Software to align single and paired end reads as short as 14 nt and of arbitrarily long length. Can detect short and long distance splicing, including interchromosomal splicing, in individual reads, using probabilistic models or database of known splice sites. Permits SNP-tolerant alignment to reference space of all possible combinations of major and minor alleles, and can align reads from bisulfite-treated DNA for study of methylation state.

Proper citation: GSNAP (RRID:SCR_005483) Copy   

•   Source: SciCrunch Registry

http://genome.jgi.doe.gov/programs/fungi/index.jsf

Fungal genomics database and interactive analytical tools that integrates all fungal genomes for diverse fungi that are important for energy and environment, the focus of the JGI Fungal program. It integrates genomics data from the DOE JGI and its users and promotes user community participation in data submission, annotation and analysis. Over 100 newly sequenced and annotated fungal genomes from JGI and elsewhere are available to the public through MycoCosm, and new annotated genomes are being added to this resource upon completion of annotation. MycoCosm offers web-based genome analysis tools for fungal biologists to ''navigate'' through sequenced genomes and explore them in the context of ''genome-centric'' and ''comparative views''.

Proper citation: MycoCosm (RRID:SCR_005312) Copy   

•   Source: SciCrunch Registry

http://bioinfo.cs.technion.ac.il/atrhunter/

Software that finds and displays approximate tandem repeats in DNA sequences.

Proper citation: ATRHUNTER (RRID:SCR_006480) Copy   

•   Source: SciCrunch Registry

http://last.cbrc.jp/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software tool for aligning sequences, similar to BLAST 2 sequences that colour-codes the alignments by reliability. Another useful feature of LAST is that it can compare huge (vertebrate-genome-sized) datasets. Unfortunately, this only applies to the downloadable version of LAST, not the web service. The web service can just about handle bacterial genomes, but it will take a few minutes and the output will be large. LAST can: * Handle big sequence data, e.g: ** Compare two vertebrate genomes ** Align billions of DNA reads to a genome * Indicate the reliability of each aligned column. * Use sequence quality data properly. * Compare DNA to proteins, with frameshifts. * Compare PSSMs to sequences * Calculate the likelihood of chance similarities between random sequences. LAST cannot (yet): * Do spliced alignment., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: LAST (RRID:SCR_006119) Copy   

•   Source: SciCrunch Registry

http://www.ncbi.nlm.nih.gov/clinvar/

Archive of aggregated information about sequence variation and its relationship to human health. Provides reports of relationships among human variations and phenotypes along with supporting evidence. Submissions from clinical testing labs, research labs, locus-specific databases, expert panels and professional societies are welcome. Collects reports of variants found in patient samples, assertions made regarding their clinical significance, information about submitter, and other supporting data. Alleles described in submissions are mapped to reference sequences, and reported according to HGVS standard.

Proper citation: ClinVar (RRID:SCR_006169) Copy   

•   Source: SciCrunch Registry

http://facil-host.cmbi.umcn.nl/facil

Genetic code prediction tool that infers the genetic code directly from any set of nucleic acid sequences and assigns a Random Forest-based reliability score to its predictions.

Proper citation: FACIL (RRID:SCR_004375) Copy   

•   Source: SciCrunch Registry

http://foldx.crg.es/

A computer algorithm that provides a fast and quantitative estimation of the importance of the interactions contributing to the stability of proteins and protein complexes. The predictive power of FOLDEF has been tested on a very large set of point mutants (1088 mutants) spanning most of the structural environments found in proteins . FoldX uses a full atomic description of the structure of the proteins. The different energy terms taken into account in FoldX have been weighted using empirical data obtained from protein engineering experiments.

Proper citation: FoldX (RRID:SCR_008522) Copy   

•   Source: SciCrunch Registry

http://www.ebi.ac.uk/Tools/sss/fasta/

Software package for DNA and protein sequence alignment to find regions of local or global similarity between Protein or DNA sequences, either by searching Protein or DNA databases, or by identifying local duplications within a sequence.

Proper citation: FASTA (RRID:SCR_011819) Copy   

•   Source: SciCrunch Registry

http://www.lcb.uu.se/lcbdw.php

A microarray-experiment oriented warehouse for collections of expression data, integrated with gene annotation profiling and used to support genomic data mining processes. It provides means to access and extract valuable information from a Laboratory Information Management System (LIMS) and makes use of several plug-ins to process and analyze the data. The system consists of two parts: MIAME compliant data storage is handled by the LIMS while data analysis is performed in the DWH. The core of the system is BASE. Accessing LIMS and DWH is accomplished through secure connections.

Proper citation: LCB-DWH (RRID:SCR_010942) Copy   

•   Source: SciCrunch Registry

https://sourceforge.net/projects/fraggenescan/

A software application for finding fragmented genes in short reads and may be applied to predict prokaryotic genes in incomplete assemblies or complete genomes.

Proper citation: FragGeneScan (RRID:SCR_011929) Copy   

•   Source: SciCrunch Registry

http://genecodis.cnb.csic.es/

Web-based tool for the ontological analysis of large lists of genes. It can be used to determine biological annotations or combinations of annotations that are significantly associated to a list of genes under study with respect to a reference list. As well as single annotations, this tool allows users to simultaneously evaluate annotations from different sources, for example Biological Process and Cellular Component categories of Gene Ontology., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: GeneCodis (RRID:SCR_006943) Copy   

•   Source: SciCrunch Registry

http://samtools.sourceforge.net/

A generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms.

Proper citation: SAM format (RRID:SCR_012093) Copy   

•   Source: SciCrunch Registry

http://migen.sourceforge.net/

Standard specification for the information required to report a genotyping experiment, covering: study and experiment design, subject information, genotyping procedure, and data analysis methods. The goal is to set a reporting standard for adoption by the research community to facilitate consistent data interpretation and independent validation/reproduction, and to serve as guidance for database design for storing genotyping experiment data. MIGen is being developed as a collaborative project involving international domain experts and is a registered project under MIBBI: Minimum Information for Biological and Biomedical Investigations.

Proper citation: MIGen (RRID:SCR_006959) Copy   

•   Source: SciCrunch Registry