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https://sites.dartmouth.edu/toxmetal/program-resources/trace-element-analysis/

Analysis of elemental composition of biological tissues and fluids by Inductively Coupled Plasma Mass spectrometry. Analysis of Arsenic species in urine and blood by chromatography-ICP-MS. Laser ablation analysis of tissue sections for imaging of elemental distributions.

Proper citation: Dartmouth Trace Element Analysis Core Facility (RRID:SCR_009777) Copy   

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http://dartmouth.eagle-i.net/i/0000012c-3d04-56dc-96ed-bdf580000000

TRAC is affiliated with the the Irradiation and Small Animal Imaging Shared Resource, which together provides irradiation services for basic and translational researchers and state-of-the-art non-invasive in vivo imaging of cultured cells and small animals. Services are used by Dartmouth investigators to irradiate cells in culture and small experimental animals. A separate set of irradiation devices is available through Norris Cotton Cancer Center for clinical and experimental irradiation of human patients.

Proper citation: Dartmouth Translational Research Animal Core (RRID:SCR_009778) Copy   

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http://harvard.eagle-i.net/i/0000013a-2c63-ce13-5088-2eef80000000

The SBGrid Core team provides research computing sysadmin support to structural biology laboratories in the Boston area.

Proper citation: HMS SBGrid Core (RRID:SCR_009811) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-c7bd-3029-a061-4a6580000000

Core facility that provides the following services: Enzyme-linked immunosorbent spot assay service, Fluorescence microscopy service, Real-time PCR Service.

The NERCE Microbiology and Animal Resources Core maintains two laboratories, a BSL-2 and a BSL-3 laboratory, to support the research efforts of all New England investigators conducting research on NIAID priority pathogens. Each laboratory provides the physical environment, equipment, and support personnel required for scientists to work with these agents. The BSL-3 laboratory is an isolated suite that includes individual laboratory rooms and rooms for housing experimental animals, all within a single containment facility. The BSL-3 lab provides the extensive security and administrative support structure required for possession of CDC select agents. The laboratory acquires strains of viruses and bacteria, prepares seed stocks, and characterizes these seed stocks using phenotypic and molecular methods to ensure a well-characterized, pure biological reagent. Laboratory staff members assist investigators with experiments involving pathogen culture, fractionation of biological material, animal challenge, and vaccine and drug administration. The laboratory is equipped for commonly used analytical methods, including fluorescence microscopy, PCR, EIA, and ELISPOT. A single suite with both laboratory and experimental animal capability eliminates the need to transport infectious material between laboratories. The BSL-2 laboratory provides support required by the BLS-3 facility, access to attenuated strains exempt from select agent registration, and laboratory space for visiting investigators. Investigators interested in working with the Microbiology and Animal Resources core laboratory should complete the Core A Request Form and send it to Christine Anderson. See lab website for details. There are no charges for projects focused on NIAID priority pathogens and agents of emerging infectious disease.

Proper citation: HMS NERCE Microbiology and Animal Resources Core (RRID:SCR_009807) Copy   

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http://harvard.eagle-i.net/i/0000012c-c7a7-e0e5-a061-4a6580000000

Core facility that provides the following services: Protein production, Bacterial fermentation for recombinant protein production, Baculovirus culture, Protein purification.

The NERCE Biomolecule Production Core Laboratory is a core service laboratory with capability for expression and purification of recombinant proteins using bacterial and baculoviral expression systems, and preparation of bacterial carbohydrate components. It supports all New England investigators conducting research on NIAID priority pathogens that requires purified proteins or carbohydrates. Investigators are expected to provide data demonstrating efficacy of production and purification methods, as well as strains or purified recombinant plasmid preparations where applicable. See lab website for details. Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.

Proper citation: HMS NERCE Biomolecule Production Core Laboratory (RRID:SCR_009804) Copy   

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http://harvard.eagle-i.net/i/0000012b-00c3-845c-db6e-7a3f80000000

Core facility that provides the following services: Soft-lithography service, Soft-lithography training and consultation.

The HMS Microfluidics Facility aims to make the tools of Microfabrication and Microfluidics available to all HMS users.

Proper citation: HMS Microfluidics Core Facility (RRID:SCR_009801) Copy   

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http://harvard.eagle-i.net/i/0000012e-5961-f9b9-55da-381e80000000

Core facility that provides the following services: Flow cytometric analysis and cell sorting. The cell sorting and analysis lab provides access to the most sophisticated flow cytometers presently available. The core is able to analyze and physically separate cells based upon features detectable with fluorescently labeled monoclonal antibodies. This facilities has two locations: the Simches site and the Charlestown Navy Yard (CNY) site.

Proper citation: MGH Flow Cytometry Core Facility (RRID:SCR_009887) Copy   

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http://jsu.eagle-i.net/i/0000012a-2505-c6a1-b307-36d480000000

Core facility that provides the following services: Statistical design and analysis. Applied statistical methodologies and data analysis techniques are critical under-girding factors in research and knowledge advancement. Appropriate experimental design lays foundation of sound research plans; sample size determines the power of significance and efficient utilization of scarce resources; and adequate data analysis generate results that are valid and true representative of the population in question. The Biostatistical Support Unit (BSU) provides statistical services and research support to RCMI investigators, other faculty, as well as to graduate and undergraduate students.(http://www.jsums.edu/cset/rcmi/bsu.htm)

Proper citation: JSU BSU-RCMI Biostatistics Core Laboratory (RRID:SCR_009888) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012b-00bc-22cd-3984-bcfb80000000

Core facility that provides the following services: Animal husbandry service. The Animal Care Facility (ACF) is one of the essential units of support and service to the biomedical research at Jackson State University. Its long term goal is to develop a state-of-the-art infrastructure as well as to provide technical and logistic support to RCMI investigators and other JSU faculty and students to conduct a high quality of animal research, in compliance with the guidelines and policies set for by accrediting and regulatory agencies, especially as they relate to IACUC protocol development, animal husbandry, food and water supply, veterinary care, quarantine and euthanasia, sanitation procedures, environmental monitoring, and record keeping. ACF provides accommodation for long-term storage of animals and maintains them in accordance with and in compliance with the PHS Policy on the Humane Care and Use of Laboratory Animals and the Animal Welfare Act, as described in the 2002 Guide for the Care and Use of Laboratory Animals.

Proper citation: JSU Animal Core Facility (RRID:SCR_009886) Copy   

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http://harvard.eagle-i.net/i/0000012e-a183-b053-55da-381e80000000

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 24, 2019. Core provides the following services: Trypsinization service. Core provides a full range of services to the Joslin research community spanning from consulting on proteomic experimental design to data acquisition and analysis. The core operates a high throughput nano liquid chromatography, nanospray ionization, LTQ 2D ion trap tandem mass spectrometer system. This system is used for two routine proteomic services, including Targeted Protein Analysis and Protein Inventory. Targeted Protein Analysis is used to identify and provide in depth characterization, including phosphorylation site mapping, of proteins isolate by SDS-PAGE. Protein Inventory is used to catalogue the protein composition in a sample separated by 1D SDS-PAGE. This service provides information on protein identification, molecular weight (gel mobility), and spectral/peptide counts, a semi-quantitative measure of protein abundance. In addition, the Core works with investigators on specialized analyses involving tandem mass spectrometry, including specialized enzymatic digests (peptide preparation), selective reaction monitoring (SRM), and targeted peptide detection. The Proteomic Core provides in house database resources and analysis tools and also coordinates with Joslin's Bioinformatics Core to provide further assistance with data organization and interpretation. The Core hosts seminars on proteomic topics and provides instruction on practical and theoretical aspects of mass spectrometry-based proteomics.

Proper citation: Joslin Diabets Center Proteomics Core Facility (RRID:SCR_009883) Copy   

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https://hddc.hms.harvard.edu/core-b

Core facility that provides service for paraffin embedding, sectioning, staining, and frozen sectioning; shared equipment and service for confocal, widefield, photodocumentation, electron microscopy, and digital image processing; and an immunostaining service.

Proper citation: Harvard Digestive Diseases Center Biomedical CORE B: Microscopy and Histopathology (RRID:SCR_009836) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c2-c99a-db6e-7a3f80000000

Core facility that provides the following services: Use of instruments service, Training service. The Harvard Center for Biological Imaging (HCBI) has been created to foster collaborative research in the most state-of-the-art facility available. To do this, we have set up a unique partnership with Carl Zeiss International in which our microscopy systems are continually replaced every 2-3 years ensuring we always have the most up-to-date equipment possible. The facility is open 24 hours/day, 7 days/week and access to the facility is open to all Harvard investigators as well as to affiliates and investigators from collaborating institutions.

Proper citation: Harvard Center for Biological Imaging (RRID:SCR_009834) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000141-ff7a-fbff-89f9-43eb80000000

Core facility that provides the following services: Computational image data analysis.

IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).

Proper citation: HMS Image and Data Analysis Core (RRID:SCR_009799) Copy   

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http://harvard.eagle-i.net/i/00000130-7571-ee45-1971-4f2080000000

Center for Nanoscale Systems facility dealing with FIB, XPS, AFM, Optical Microscopy and Spectroscopy, Biomaterials, Soft Lithography, Microfluidics, Nano Particles, Chemical Nanotechnology, etc.

Proper citation: Harvard CNS Nanomaterial Facility (RRID:SCR_009833) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6d67-5282-55da-381e80000000

Core facility that provides the following services: Autoantibody determination, HLA typing and Genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4).

The Human Sample Procurement Core will support translational research endeavors within the JDRF Center by providing the Center''s laboratories access to well-characterized blood samples from patients with diabetes at different stages of the disease. This availability will greatly facilitate the translational exploration of concepts and targets emerging from the basic research projects. Individuals with T1D (recent onset, long-standing Type-1 diabetes) and matched controls (healthy or T2D) will be recruited from the patient population at the Joslin Diabetes Center and neighboring institutions. The Core will perform and record a basic characterization of patients and their samples. This analysis will include a thorough evaluation of clinical characteristics from a diabetes and autoimmune standpoint, and an immunogenetic workup (outsourced to Joslin or other cores): autoantibody determination, HLA typing and genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4). A relational database will be adapted to record all patient information, copies of which will be provided in a de-identified manner to the investigators.

Proper citation: HMS Human Sample Procurement Core Facility (RRID:SCR_009797) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012a-2502-2ecd-f94c-e32480000000

Core facility that provides the following services: Access/training service.

Lab performs services related to paleontology, paleopathology, and paleohistology. This core houses significant expertise in processing and analysis of mineralized tissues.

Proper citation: MSU Paleohistology Core Laboratory (RRID:SCR_009831) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-e9d1-5617-794280000000

Core facility that provides the following services: Small molecule and peptide NMR spectrometry service. Formerly the NERCE NMR Resource. Nuclear magnetic resonance spectroscopy is a powerful tool for studying structural and conformational parameters of molecules. This tool is vital for the chemical analysis of both small molecules (like those discovered in small-molecule screens) and large molecules, such as carbohydrates and proteins found to have potential biologic importance.

Proper citation: HMS East Quad NMR Core Facility (RRID:SCR_009795) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-25bf-69ed-f5ed-943080000000

Core facility that provides the following services: Maintainence and dissemination of transgenic and mutant mice.

The Genetically Modified NOD Mouse Core provides Center investigators, as well as researchers elsewhere, with access to transgenic and mutant lines derived from the NOD mouse model: some will be generated within the Core; others are established lines of proven experimental value that are maintained in the Core. The Core will construct transgenic mice in strains that have a high susceptibility to diabetes (in particular in the NOD line). This includes trangenesis by conventional pronuclear injection or by delivery of RNAi cassettes on lentiviral vectors. The Core will also provide a panel of existing transgenic and mutant lines. These lines are chosen because of their established interest in allowing the dissection of immunological tolerance in Type 1 Diabetes, and in response to Center investigator needs.

Proper citation: HMS Genetically Modified NOD Mouse Core Facility (RRID:SCR_009796) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-4d06-be70-2162-17a280000000

Core facility that provides the following services: Drosophila genome-wide and focused cell-based RNAi libraries, Custom synthesis of double-stranded RNAs for Drosophila cell-based RNAi.

The DRSC facilitates genome-wide and related cell-based screening at our state-of-the-art facility. Since our beginnings in 2003, we have successfully guided screeners through the process, including help with assay development and optimization, data and image analysis, and planning of follow-up assays. Screens performed at the DRSC have resulted in an impressive number of publications on a wide range of topics in high-profile journals.

Proper citation: HMS Drosophila RNAi Screening Center (RRID:SCR_009794) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-3576-60d7-550e-f59280000000

Flow cytometry access facility. All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility. All users must obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility.

Proper citation: HSPH Flow Cytometry Facility (RRID:SCR_009825) Copy   

•   Source: SciCrunch Registry