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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
https://www.hupo.org/human-antibody-initiative/
THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 19, 2022.The mission of the Human Antibody Initiative (HAI) aims to promote and facilitate the use of antibodies for proteomics research. The initiative consists of two separate activities; (1) the generation of a catalogue of validated antibodies from many different sources and (2) a protein atlas for the expression and localization of human proteins in normal and disease tissue. The two separate activities have as their primary deliverables to generate databases with free public accessibility. The Antibody Resource database (www.antibodypedia.org) is aimed to produce a comprehensive catalogue of validated antibodies towards human proteins. This initiative depends on input from a large number of academic groups and commercial companies. The Protein Atlas initiative (www.proteinatlas.org) is aimed to provide comprehensive and annotated database of high-resolution images showing tissue profiles in normal and cancer tissues. Both databases will be open to the public without restriction (no passwords).
Proper citation: HUPO Antibody Initiative (RRID:SCR_004568) Copy
An open source and domain independent Workflow Management System ����?? a suite of tools used to design and execute scientific workflows and aid in silico experimentation. Taverna Workbench now has support for service sets, offline workflow editing, workflow validation, improved workflow run monitoring, and the pausing and canceling of workflow runs. The command line tool allows you to run workflows outside of the workbench and is available as a stand-alone download or bundled with the Taverna Workbench 2.2.0 download. The Taverna suite is written in Java and includes the Taverna Engine (used for enacting workflows) that powers both the Taverna Workbench (the desktop client application) and the Taverna Server (which allows remote execution of workflows). Taverna is also available as a Command Line Tool for a quick execution of workflows from a terminal. Taverna 2.2.0 includes * Copy/paste, shortcuts, undo/redo, drag and drop * Animated workflow diagram * Remembers added/removed services * Secure Web services support * Secure access to resources on the web * Up-to-date R support * Intermediate values during workflow runs * myExperiment integration * Excel and csv spreadsheet support * Command line tool
Proper citation: Taverna (RRID:SCR_004437) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented October 13, 2014. The resource has moved to the NIDDKInformation Network (dkNET) project. Contact them at info_at_dknet.org with any questions. Database of large pools of data relevant to the mission of NIDDKwith the goal of developing a community-based network for integration across disciplines to include the larger DKuniverse of diseases, investigators, and potential users. The focus is on greater use of this data with the objective of adding value by breaking down barriers between sites to facilitate linking of different datasets. To date (2013/06/10), a total of 1,195 resources have been associated with one or more genes. Of 11,580 total genes associated with resources, the ten most represented are associated with 359 distinct resources. The main method by which they currently interconnect resources between the providers is via EntrezGene identifiers. A total of 780 unique genes provide the connectivity between 3,159 resource pairs across consortia. To further increase interconnectivity, the groups have been further annotating their data with additional gene identifiers, publications, and ontology terms from selected Open Biological and Biomedical Ontologies (OBO).
Proper citation: dkCOIN (RRID:SCR_004438) Copy
http://magnet.c2b2.columbia.edu/
The mission of the Center for the Multiscale Analysis of Genomic and Cellular Networks (MAGNet) is to develop novel Structural and Systems Biology methods and tools for the dissection of molecular interactions in the cell and for the interaction-based elucidation of cellular phenotypes. These tools are made freely available to the the members of the research community. They are also validated in the context of the Center''''s own research program through collaborative projects with experimental biologists. MAGNet is one of 7 National Centers for Biomedical Computing (NCBC). These Centers, in conjunction with individual investigator awards, are creating a networked effort to build the computational infrastructure for biomedical computing in the nation. The NCBC program is devoted to all facets of biomedical computing, from basic research in computational science to providing the tools and resources that biomedical and behavioral researchers need to do their work. In addition to carrying out fundamental research the NCBCs play a major role in educating and training researchers to engage in biomedical computing. MAGNet is also one of 12 inter-disciplinary Centers for Cancer Systems Biology (CCSBs), a component of the National Cancer Institute''''s Integrative Cancer Biology Program. The CCSBs provide a core framework for applying systems biology approaches to cancer research through the development and implementation of computational models of processes relevant to cancer prevention, diagnostics and therapeutics. The CCSBs seek to integrate experimental biology with mathematical modeling to foster new insights in the biology and new approaches to the management of cancer. MAGNet''''s Training Core ensures that the methods developed by the Center are integrated into the educational offerings of Columbia University''''s Medical School.
Proper citation: MAGNet - Multiscale Analysis of Genomic and Cellular Networks (RRID:SCR_004399) Copy
http://okcam.cbi.pku.edu.cn/ontology.php
CAMO (Cell Adhesion Molecule Ontology) is a set of standard vocabulary that provide a hierarchical description of cell adhesion molecules and their functions. We compiled a list for cell adhesion molecules by integrating Gene Ontology annotations, domain structure information, and keywords query against NCBI Entrez Gene annotations. Totally 496 unique human genes were identified to function as cell adhesion molecules, which is by far the most comprehensive dataset including cadherin, immunoglobulin/FNIII, integrin, neurexin, neuroligan, and catenin families. CAMO was constructed as a directed acyclic graph (DAG) using DAG-Edit to input, manage and update data. We annotated each term with name, definition and source references, as well as the relationship to other terms, based on manual reviews of domain architecture and functional annotations. If vertices represent terms and the relationships between terms are represented by edges, the terms in a DAG can be connected via a directed graph without cycles. CAMO thus provides a hierarchical description of functions of CAMs with five top-level categories: CAM gene families, CAM genetics, CAM regulation, CAM expression and CAM diseases. Each top-level term is further divided into several categories to describe the functions in detail.
Proper citation: CAMO - Cell Adhesion Molecule Ontology (RRID:SCR_004392) Copy
The Biomedical Research Program (PIB) of the School of Medical Sciences was created in 2007, after a Collaboration Protocol was established between UCA and the National Council of Scientific and Technical Research (CONICET). Research at PIB aims at unraveling the molecular, biochemical and genetic aspects of human diseases, therefore contributing to understanding complex pathologies. Research Groups include: * Molecular and Cell Biology Lab (LBCM) - Group leader: Tom��s A. Santa Coloma, Ph.D. * Nanotechnology Lab - Group leader: Tom��s A. Santa Coloma, Ph.D. * Molecular Neurobiology Lab - Group leader: Francisco J. Barrantes, Ph.D.
Proper citation: Biomedical Research Program UCA (RRID:SCR_004395) Copy
http://www.openanesthesia.org/
OpenAnesthesia.org is a wiki promoting evidence-based medicine in anesthesiology, critical care and pain management. It is divided into several, major Units (Anesthesia Text, Critical Care Manual, Practice-Changing Articles, Controversies in Anesthesia, ABA keywords, Audio/Video Archives, CME, GME, Pharmacology...), each of which is subdivided into Chapters (or in some cases, even smaller subdivisions, such as sections, individual key words, topics, points of interest, or bibliographic references). The goal of Anasthesia Text is to collect and distribute evidence-based information regarding all aspects of anesthesia. This section is similar to a traditional textbook in the broad range of topics covered, but different in that it will provide this information in the form of a wiki (i.e. anyone can edit, add, or subtract to it). OpenAneshesia.org provides anesthesia residents with GME credit and Program Directors with a tool to document core competency activities for Accreditation Council for Graduate Medical Education (ACGME)-mandated learning portfolios. Residents are invited invited to read the Anesthesia & Analgesia article of the month and listen to an interview with one of the article''s authors. During the interview, the author will discuss the specifics of the article as well as general topics geared towards improving each resident''s appreciation of basic or clinical research. After listening to the podcast and reading the article, residents can answer 5 questions in order to demonstrate their mastery of the topics discussed (similar to the Anesthesia & Analgesia Continuing Medical Education (CME) section). Like the CME section, after demonstrating proficiency, a resident will receive a printable certificate that will specify which ACGME core competencies were addressed in the article and interview. The certificates can be put in each resident''s ACGME-required learning portfolio.
Proper citation: OpenAnesthesia.org (RRID:SCR_004547) Copy
http://en.wikibooks.org/wiki/Diagnostic_Radiology
This is a wiki on diagnostic radiology. Major topics include General Types of Radiology, Imaging Modalities, Radiography, CT scanning, Sonography, MRI Magnetic Resonance Imaging, Nuclear medicine, Normal Radiological Anatomy, Imaging of Specific Anatomic Regions, Diagnosis of Specific Anatomic Regions, Imaging in Pediatric Radiology, and External resources. Radiology is the branch of medical science dealing with medical imaging. It may use x-ray machines or other such radiation devices. It also uses techniques that do not involve radiation, such as MRI and ultrasound. The medical information provided on Wikibooks is, at best, of a general nature and cannot substitute for the advice of a medical professional (for instance, a qualified doctor/physician, nurse, pharmacist/chemist, and so on). Wikibooks is not a doctor.
Proper citation: Diagnostic Radiology (RRID:SCR_004427) Copy
An accurate and reliable method for identifying athletes with head trauma, and a strong candidate rapid sideline screening test for concussion. The test is able to capture impairments of eye movement, attention, language and other symptoms of impaired brain function. It is a physical method of evaluating visual tracking and saccadic eye movements is based on the time to perform rapid number naming. It involves reading aloud a series of single digit numbers from left to right on three test cards. Participants are asked to read the numbers on each card from left to right as quickly as possible but without making any errors. The sum of the three test card time scores constitutes the summary score for the entire test. The test is a proven indicator of oculomotor inefficiencies regarding eye movements during reading. Published medical studies have determined that deficiencies in saccadic eye movements can be an indicator of mild Traumatic Brain Injury (mTBI) or concussions. Studies have shown that there is a significant relationship between poor oculomotor functions and learning disabilities (including dyslexia detection). Saccadic eye movement deficiencies can be improved with training and correspondingly reading performance also can be improved. Simply put, subjects who don''t perform well on this test are not efficient readers, although because there are many reasons for poor reading unrelated to eye movements, some poor readers do fine on the test. They believe that the test should be in the hands of teachers in order to help them determine if a student''s poor reading performance is related to deficiencies in their ability to move their eyes efficiently.
Proper citation: King-Devick Test (RRID:SCR_004500) Copy
http://www.chdifoundation.org/
A private, not-for-profit research organization that serves as an international collaborative enabler in order to discover drugs that slow the progression of Huntington's disease (HD). The activities of CHDI extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials. CHDI works with biotech and pharmaceutical companies and funds and works with academic HD researchers at universities.
Proper citation: CHDI Foundation (RRID:SCR_004622) Copy
SchistoDB is a genomic database for the parasitic organism Schistosoma mansoni, one of the major causative agents of schistosomiasis worldwide. It currently incorporates sequences and annotation for S. mansoni in a single user-friendly database. Several genomic scale analyses are available as well as ESTs, oligonucleotides, metabolic pathways and drugs. Make your data available: If you''d like to have your updates and/or datasets integrated in SchistoDB, drop us an email.
Proper citation: Schistosoma mansoni Database (RRID:SCR_004341) Copy
http://code.google.com/p/rna-star/
Software performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
Proper citation: STAR (RRID:SCR_004463) Copy
http://www.essentialtremor.us/
Finding a cure for any neurological disorder begins with the scientific study of the disorder''s causes, processes, and development in the brain. For essential tremor (ET), rigorous study of this kind had not been undertaken until 2003, when the Essential Tremor Centralized Brain Repository (ETCBR) was established at Columbia University. For the past five years, brain tissue from ET donors has been collected, processed and compared alongside age-matched control brains at the ETCBR, and already several significant findings have been made. However, there is still much to learn and a severe shortage of ET brains for scientific study. If you have been diagnosed with essential tremor, donating your brain tissue in the hours immediately after your death is of utmost importance in providing crucial information about what causes ET. Direct analysis of the shape and number of nerve cells and their content will provide medical researchers with the information they need in order to understand this complex illness. By advancing our medical knowledge of ET, the gift of brain tissue is a central piece of the puzzle in the search to develop better treatments and find a cure.
Proper citation: Essential Tremor Centralized Brain Repository (RRID:SCR_004464) Copy
The National Alliance for Medical Image Computing (NA-MIC) is a multi-institutional, interdisciplinary team of computer scientists, software engineers, and medical investigators who develop computational tools for the analysis and visualization of medical image data. The purpose of the Center is to provide the infrastructure and environment for the development of computational algorithms and open-source technologies, and then oversee the training and dissemination of these tools to the medical research community. Electronic resources provided by NA-MIC include software, data, tutorials, presentations, and more.
Proper citation: National Alliance for Medical Image Computing (RRID:SCR_004460) Copy
Platform to facilitate sharing, discovery, and secure access to UCSF biomedical data. It''s powered by the Dataverse Network platform, which supports a variety of data types, as well as attribution and licensing needs. Researchers may share datasets, discover data from other labs, and reuse data. Links to tools and information that help scientists properly organize, manage, and document their datasets are also provided.
Proper citation: UCSF DataShare (RRID:SCR_004340) Copy
https://bams1.org/ontology/viewer.php
Ontology designed for neuroscience. Includes complete set of concepts that describe parts of rat nervous system, growing set of concepts that describe neuron populations identified in different brain regions, and relationships between concepts.
Proper citation: BAMS Neuroanatomical Ontology (RRID:SCR_004616) Copy
http://www.xenbase.org/anatomy/xao.do?method=display
A structured, controlled vocabulary of the anatomy and development of the African clawed frogs (Xenopus laevis and tropicalis), organized in a graphical structure. Tissues are shown as being part of other tissues and the timing of their development is indicated by start and end stages. The lineage of tissues is represented by develops from relationships between different tissues at different developmental stages. Many items have been classified according to the Common Anatomy Reference Ontology. The Xenopus Anatomical Ontology will be used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes. Its robust developmental map will enable powerful database searches and data analyses. They encourage community recommendations for updates and improvements to the ontology.
Proper citation: Xenopus Anatomy Ontology (RRID:SCR_004337) Copy
http://www.ganfyd.org/index.php?title=Main_Page
Simply put ganfyd is an evolving textbook of medicine: a free medical knowledge base that anyone can read and any registered medical practitioner may edit. This collaborative medical reference by medical professionals and invited non-medical experts is based around the wiki format, enabling true sharing of knowledge. Please join and help us to create a great source of information and experience! Ganfyd is the first of its type and relies on your contributions to make it a truly world-class resource. Contents: * Medical Specialties * Surgical Specialties * Primary Care * Public Health * Laboratory-based specialties * Imaging Specialties * Basic Medical Sciences * Miscellaneous * Women''s health * Survival Guides * How-tos & Practical Advice * Resources for Trainees * Computing * Medical Dictionary
Proper citation: Ganfyd - Get A Note From Your Doctor (RRID:SCR_004606) Copy
A web-based browser for Gene Ontology terms and annotations, which is provided by the UniProtKB-GOA group at the EBI. It is able to offer a range of facilities including bulk downloads of GO annotation data which can be extensively filtered by a range of different parameters and GO slim set generation. The software for QuickGO is freely available under the Apache 2 license. QuickGO can supply GO term information and GO annotation data via REST web services.
Proper citation: QuickGO (RRID:SCR_004608) Copy
Database providing access to quality controlled Open Access Journals. For a journal to be included it should exercise quality control on submitted papers through an editor, editorial board and/or a peer-review system. It is not be limited to particular languages or subject areas. Offering free online access to high quality full text content, plus excellent search tools, the portal enables researchers to find, use and re-use a vast range of materials with ease. The content of DOAJ will be even more visible and disseminated through this portal. The aim of the Directory is to increase the visibility and ease of use of open access scientific and scholarly journals thereby promoting their increased usage and impact. As of April 2014, DOAJ has 9,709 journals, 5,624 journals searchable at article level, 133 Countries and 1,600,991 articles. The database may be browsed by title or subject, or searched through the interface to for journals or articles.
Proper citation: DOAJ - Directory of Open Access Journals (RRID:SCR_004521) Copy
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