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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
MUSCLE
 
Resource Report
Resource Website
10000+ mentions
MUSCLE (RRID:SCR_011812) MUSCLE data analysis service, data processing software, alignment software, data analysis software, analysis service resource, software resource, software application, image analysis software, production service resource, service resource Multiple sequence alignment method with reduced time and space complexity.Multiple sequence alignment with high accuracy and high throughput. Data analysis service for multiple sequence comparison by log- expectation. bio.tools is used by: TranslatorX
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
is related to: PREFAB
has parent organization: European Bioinformatics Institute
PMID:15034147
PMID:15318951
DOI:10.1093/nar/gkh340
biotools:muscle, OMICS_00982 https://bio.tools/muscle, http://www.drive5.com/muscle/, https://www.drive5.com/muscle/manual/, https://www.drive5, http://bioconductor.org/packages/release/bioc/html/muscle.html.com/muscle/manual/install.html, https://sources.debian.org/src/muscle/ SCR_011812 MUltiple Sequence Comparison by Log- Expectation 2026-08-04 09:42:51 16137
neXtProt
 
Resource Report
Resource Website
100+ mentions
neXtProt (RRID:SCR_008911) topical portal, portal, database, data or information resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2025. Human protein knowledge platform. Knowledge platform for human proteins selects and filters high throughput data pertinent to human proteins from UniProtKB. Extends UniProtKB/Swiss-Prot annotations for human proteins to include several new data types. Protein, proteomics, sirna, 3d, pathway, variant, protein-protein interaction, protein-drug interaction, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
is related to: UniProtKB
has parent organization: SIB Swiss Institute of Bioinformatics
Swiss Commission for Technology and Innovation ;
SIB
PMID:22139911 THIS RESOURCE IS NO LONGER IN SERVICE biotools:nextprot, nlx_151482 https://bio.tools/nextprot SCR_008911 2026-08-04 09:42:14 166
PLINK/SEQ
 
Resource Report
Resource Website
50+ mentions
PLINK/SEQ (RRID:SCR_013193) software application, software toolkit, software resource, software library An open-source C/C++ library for working with human genetic variation data. The specific focus is to provide a platform for analytic tool development for variation data from large-scale resequencing projects, particularly whole-exome and whole-genome studies. However, the library could in principle be applied to other types of genetic studies, including whole-genome association studies of common SNPs. (entry from Genetic Analysis Software) gene, genetic, genomic, c/c++, r, macos, linux, bio.tools is listed by: Genetic Analysis Software
is listed by: bio.tools
is listed by: Debian
is related to: PLINK
has parent organization: Harvard University; Cambridge; United States
Open unspecified license nlx_154213, biotools:plink-seq https://bio.tools/plink-seq SCR_013193 2026-08-04 09:43:09 77
PASA
 
Resource Report
Resource Website
500+ mentions
PASA (RRID:SCR_014656) data processing software, data analysis software, software resource, sequence analysis software, software application Gene structure annotation and analysis tool that uses spliced alignments of expressed transcript sequences to automatically model gene structures. It also incorporates gene structures based on transcript alignments into existing gene structure annotations. It is one component of a larger eukayotic annotation pipeline implemented at the Broad Institute. gene structure, annotation, gene structure analysis tool, spliced alignment, transcript sequence, bio.tools is used by: BRO_annotation
is listed by: Debian
is listed by: bio.tools
DOI:10.1093/nar/gkg770 Available for download biotools:PASA https://bio.tools/PASA SCR_014656 Program to Assemble Spliced Alignments (PASA), Program to Assemble Spliced Alignments 2026-08-04 09:43:30 999
Molecular Dynamics Workflow (BioKepler)
 
Resource Report
Resource Website
1+ mentions
Molecular Dynamics Workflow (BioKepler) (RRID:SCR_014389) data processing software, software application, software resource, workflow software A workflow for running molecular dynamics simulations. It can be used for all-atom molecular dynamic simulations, which involve five steps of minimization, one step of heating, three steps of equilibration, and one or more instances of production. The input is a set of directories that include the MD simulation input scripts, system topology and coordinate files. Output files are list of plots, simulation trajectories, intermediate files, restart files, and the like. workflow, MD, molecular dynamics, simulation, software, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: bioKepler
has parent organization: University of California at San Diego; California; USA
NIGMS P41GM103426 Requires Linux biotools:ambergpumdsimulation http://nbcr.ucsd.edu/data/downloads/workflows/, https://bio.tools/ambergpumdsimulation SCR_014389 Molecular Dynamics Workflow, AmberGPUMDSimulation, Molecular Dynamics Workflow Software, Amber GPUMD Simulation 2026-08-04 09:43:25 1
tximport
 
Resource Report
Resource Website
50+ mentions
tximport (RRID:SCR_016752) data processing software, software application, software resource, data analysis software Software R package for importing pseudoaligned reads into R for use with downstream differential expression analysis. Used for import and summarize transcript level estimates for transcript and gene level analysis. pseudoaligned, reads, R, differential, expression, analysis, gene, transcript, bio.tools is listed by: Bioconductor
is listed by: Debian
is listed by: bio.tools
works with: edgeR
works with: DESeq2
SNSF 143883;
European Commission ;
NCI T32 CA009337
DOI:10.12688/f1000research.7563.1 Free, Available for download, Freely available biotools:tximport https://bioconductor.org/packages/tximport/, https://bioconductor.org/packages/devel/bioc/vignettes/tximport/inst/doc/tximport.html, https://github.com/F1000Research/tximport, https://bio.tools/tximport https://zenodo.org/record/35123#.W_w3behKiM8 SCR_016752 tximport v1.4.0 2026-08-04 09:43:59 91
Nephele
 
Resource Report
Resource Website
10+ mentions
Nephele (RRID:SCR_016595) data analysis service, analysis service resource, software resource, production service resource, service resource, web application Cloud based platform for simplified, standardized and reproducible microbiome data analysis. Allows users to process microbiome datasets through pipelines of existing software tools. microbiome, datasets, process, analyze, metagenome, sequencing, data, bio.tools uses: mothur
uses: QIIME
uses: biobakery
uses: A5-miseq
is listed by: NIAID
is listed by: bio.tools
is listed by: Debian
has parent organization: OCICB
NIH Department of Health and Human Services GS35F0373X PMID:29028892 Free, Available for download, Freely available biotools:nephele https://github.com/niaid/Nephele, https://bio.tools/nephele SCR_016595 2026-08-04 09:43:56 27
ngsRelate
 
Resource Report
Resource Website
1+ mentions
ngsRelate (RRID:SCR_016588) data processing software, software application, software resource, data analysis software Software tool for estimating pairwise relatedness from next-generation sequencing data. estimating, pairwise, relatedness, next, generation, sequencing, data, bio.tools, bio.tools is listed by: Debian
is listed by: bio.tools
Danish National Research Foundation ;
Danish Council for Independent Research
PMID:26323718 Free, Available for download, Freely available biotools:ngsRelateV2, biotools:ngsrelate https://bio.tools/ngsRelateV2, https://bio.tools/ngsrelate http://www.popgen.dk/software/index.php?title=NgsRelate&oldid=694 SCR_016588 ngsRelateV2 2026-08-04 09:43:56 6
HiC-Pro
 
Resource Report
Resource Website
100+ mentions
HiC-Pro (RRID:SCR_017643) data processing software, software application, software resource, workflow software Software tool as optimized and flexible pipeline for Hi-C data processing. Used to process Hi-C data, from raw fastq files, paired end Illumina data, to normalized contact maps. Hi-C, data, raw, fastq, file, paired, Illumina, normalized, contact, map, bio.tools is listed by: Debian
is listed by: bio.tools
France Genomique National infrastructure ;
Labex Deep ;
European Research Coucil ;
ERC Advanced Investigator award ;
European Commission ;
ABS4NGS project ;
National Human Genome Research Institute ;
Paris Alliance of Cancer Research Institutes ;
Howard Hughes Medical Institute
PMID:26619908 Free, Available for download, Freely available biotools:hic-pro https://bio.tools/hic-pro SCR_017643 2026-08-04 09:44:12 206
OrthoFinder
 
Resource Report
Resource Website
1000+ mentions
OrthoFinder (RRID:SCR_017118) data processing software, software application, software resource, data analysis software Software Python application for comparative genomics analysis. Finds orthogroups and orthologs, infers rooted gene trees for all orthogroups and identifies all of gene duplcation events in those gene trees, infers rooted species tree for species being analysed and maps gene duplication events from gene trees to branches in species tree, improves orthogroup inference accuracy. Runs set of protein sequence files, one per species, in FASTA format. comparative, genomic, analysis, find, orthogroup, ortholog, infer, gene, tree, duplicate, accuracy, protein, sequence, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Bill and Melinda Gates Foundation ;
UKAID
PMID:26243257
DOI:10.1101/466201
Free, Available for download, Freely available biotools:OrthoFinder, OMICS_09733, BioTools:OrthoFinder https://bio.tools/OrthoFinder, https://bio.tools/OrthoFinder, https://bio.tools/OrthoFinder SCR_017118 OrthoFinder2, OrthoFinder 2026-08-04 09:44:04 2899
scanpy
 
Resource Report
Resource Website
100+ mentions
scanpy (RRID:SCR_018139) data processing software, software application, software resource, data analysis software Software Python tool for large scale single cell gene expression data analysis. Integrates analysis possibilities of established R-based frameworks, provides pre processing, visualization, graph-drawing and diffusion maps, clustering, identification of marker genes for clusters via differential expression tests and pseudo temporal ordering via diffusion pseudo time. Large scale, single cell, gene expression, data analysis, R, pre processing, visualization, graph drawing, diffusion map, clustering, marker gene, differential expression test, bio.tools uses: BBKNN
is used by: triku
is used by: MUON
is listed by: Debian
is listed by: bio.tools
is related to: Anndata
has plug in: infercnvpy
Helmholtz Postdoc Programme ;
German Research Foundation
PMID:29409532 Free, Available for download, Freely available biotools:scanpy, BioTools:scanpy https://icb-scanpy.readthedocs-hosted.com/en/stable/, https://bio.tools/scanpy, https://bio.tools/scanpy, https://bio.tools/scanpy SCR_018139 Single Cell Analysis in Python 2026-08-04 09:44:16 221
DrivAER
 
Resource Report
Resource Website
1+ mentions
DrivAER (RRID:SCR_019076) data processing software, software application, software resource, data analysis software Software tool as method for identification of driving transcriptional programs based on AutoEncoder derived Relevance scores. Infers relevance scores for transcriptional programs with respect to specified outcomes of interest in single-cell RNA sequencing data, such as psuedotemporal ordering or disease status.Used for manifold interpretation in scRNA-seq data. Manifold interpretation, scRNAseq data, relevance scores infering, transcriptional program, psuedotemporal ordering, disease status, data, bio.tools is listed by: bio.tools
is listed by: Debian
Free, Available for download, Freely available biotools:drivaer https://bio.tools/drivaer SCR_019076 Driving transcriptional programs using AutoEncoder based Relevance scores 2026-08-04 09:44:28 1
Epigenomics Workflow on Galaxy and Jupyter
 
Resource Report
Resource Website
1+ mentions
Epigenomics Workflow on Galaxy and Jupyter (RRID:SCR_017544) data processing software, data analysis software, workflow, software resource, training material, software application, narrative resource, data or information resource Software tool as epigenomics analysis pipeline for analysis of ChIP-Seq and RNA-Seq data using Docker images containing Galaxy and Jupyter. Epigenomic, analysis, pipeline, ChIP-Seq, RNA-Seq, data, Galaxy, Jupyter, bio.tools is listed by: bio.tools
is listed by: Debian
Agencia Estatal de Investigación of Spain SEV-2016-0672 (2017-2021) Free, Available for download, Freely available biotools:Epigenomics_Workflow_on_Galaxy_and_Jupyter https://zenodo.org/record/3298029, https://bio.tools/Epigenomics_Workflow_on_Galaxy_and_Jupyter SCR_017544 REA pipeline 2026-08-04 09:44:09 2
IMGT HighV-QUEST
 
Resource Report
Resource Website
10+ mentions
IMGT HighV-QUEST (RRID:SCR_018196) data processing software, portal, alignment software, analysis service resource, software resource, software application, image analysis software, production service resource, service resource, data or information resource Next generation B and T cell sequence alignment and characterization online surface by IMGT. Web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing. Next generation sequencing, B cell, T cell, sequence alignment, immunoglobulin, antibody, T cell receptor, analysis, sequence, bio.tools is listed by: bio.tools
is listed by: Debian
NHMRC ;
MESR ;
CNRS ;
Université Montpellier 2 ;
France ;
GENCI
PMID:22647994
PMID:23995877
PMID:22665256
Restricted biotools:IMGt_HighV-QUESt https://bio.tools/IMGT_HighV-QUEST SCR_018196 IMGT/HighV QUEST, IMGT/HighV-QUEST, IMGT web portal 2026-08-04 09:44:18 11
PM4NGS
 
Resource Report
Resource Website
1+ mentions
PM4NGS (RRID:SCR_019164) data processing software, data analysis software, data management software, software resource, software application, workflow software, software toolkit Software tool to generate standard organizational structure for Next Generation Sequencing data analysis. Includes directory structure for project, several Jupyter notebooks for data management and CWL workflows for pipeline execution. NGS workflow, standard organizational structure generation, Next Generation Sequencing data, NGS data analysis, NGS data analysis workflow, data integration, Jupyter notebook, CWL format, bio.tools is listed by: bio.tools
is listed by: Debian
Intramural Research Program of the National Library of Medicine NIH DOI:10.7490/f1000research.1117155.1 Free, Freely available biotools:pm4ngs https://bio.tools/pm4ngs SCR_019164 Project Manager for Next Generation Sequencing 2026-08-04 09:44:30 1
ComplexHeatmap
 
Resource Report
Resource Website
1000+ mentions
ComplexHeatmap (RRID:SCR_017270) data processing software, data analysis software, software resource, software application, data visualization software Software package to arrange multiple heatmaps and support various annotation graphics. Used to visualize associations between different sources of data sets and to reveal potential patterns. arrange, multiple, heatmap, visualize, data, pattern, genomic, dataset, bio.tools is listed by: Debian
is listed by: bio.tools
German Cancer Research Center-Heidelberg Center for Personalized Oncology ;
BMBF
PMID:27207943 Free, Available for download, Freely available biotools:complexheatmap https://github.com/jokergoo/ComplexHeatmap, https://bio.tools/complexheatmap SCR_017270 2026-08-04 09:44:07 3266
SWISS-MODEL
 
Resource Report
Resource Website
1000+ mentions
SWISS-MODEL (RRID:SCR_018123) web service, software resource, data access protocol, service resource, data or information resource Software tool as fully automated protein structure homology modeling server, accessible via ExPASy web server, or from program DeepView Swiss Pdb-Viewer. Structural bioinformatics web-server dedicated to homology modeling of 3D protein structures. Used to make protein modelling accessible to all biochemists and molecular biologists. 3D protein structure, homology modeling server, protein modeling, structural bioinformatics, automated comparative modeling, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: ExPASy Bioinformatics Resource Portal
is related to: Swiss-PdbViewerDeepViewv4.0
has parent organization: University of Basel; Basel; Switzerland
provides: SWISS-MODEL Repository
PMID:12824332 Free, Freely available biotools:swiss-model_workspace, biotools:swiss_model https://bio.tools/swiss_model, https://bio.tools/swiss-model_workspace SCR_018123 2026-08-04 09:44:17 2796
SIGNOR
 
Resource Report
Resource Website
10+ mentions
SIGNOR (RRID:SCR_018485) storage service resource, data repository, service resource, database, data or information resource Software application to organize and store in structured format signaling information published in scientific literature. Information is stored as binary causative relationships between biological entities and can be represented graphically as activity flow. Each relationship is linked to literature reporting experimental evidence. Each node is annotated with chemical inhibitors that modulate its activity. Signaling information is mapped to human proteome. SIGNOR 2.0 stores manually annotated causal relationships between proteins and other biologically relevant entities including chemicals, phenotypes, complexes, etc with compliance to FAIR data principles. Signal transduction data, signaling information, published data collection, activity flow, chemical inhibitor, human proteome, manually annotated data, protein, protein relationship, FAIR data, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: REDIportal
Italian Association for Cancer Research ;
ELIXIR-IIB ;
Italian Node of the European ELIXIR infrastructure ;
EMBL-EBI
PMID:31665520 Free, Available for download, Freely available biotools:signor https://bio.tools/signor SCR_018485 SIGnaling Network Open Resource, SIGNOR 2.0 2026-08-04 09:44:21 40
AmphoraNet
 
Resource Report
Resource Website
10+ mentions
AmphoraNet (RRID:SCR_005009) AmphoraNet data analysis service, analysis service resource, production service resource, service resource Webserver implementation of the AMPHORA2 workflow for phylogenetic analysis of metagenomic shotgun sequencing data. It is capable of assigning a probability-weighted taxonomic group for each phylogenetic marker gene found in the input metagenomic sample. dna sequence, amino acid sequence, dna, sequence, amino acid, phylogenetic, reliability score, nucleotide, protein, nucleotide sequence, protein sequence, phylogenetic analysis, metagenomic, metagenomics, phylotyping, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Eotvos Lorand University; Budapest; Hungary
PMID:24144838 Acknowledgement requested, Free, Public biotools:amphoranet, OMICS_01450 https://bio.tools/amphoranet SCR_005009 2026-08-04 09:41:16 16
MLTreeMap
 
Resource Report
Resource Website
1+ mentions
MLTreeMap (RRID:SCR_004792) MLTreeMap data analysis service, analysis service resource, production service resource, service resource Data analysis service that analyzes DNA sequences and determines their most likely phylogenetic origin. Its main use is in metagenomics projects, where DNA is isolated directly from natural environments and sequenced (the organisms from which the DNA originates are often entirely undescribed). It will search such sequences for suitable marker genes, and will use maximum likelihood analysis to place them in the ''''Tree of Life''''. This placement is more reliable than simply assessing the closest relative of a sequence using BLAST. More importantly, MLTreeMap decides not only who is the closest relative of your query sequence, but also how deep in the tree of life it probably branched off. Additionally, MLTreeMap searches the sequences for genes, which are coding for key enzymes of important functional pathways, such as RuBisCo, methane monooxygenase or nitrogenase. In case of a positive hit, MLTreeMap uses maximum likelihood analysis to place them in the respective ''''gene-family tree''''. phylogeny, gene, fasta, dna sequence, nucleotide sequence, metagenomics, metagenome, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: COG
has parent organization: University of Zurich; Zurich; Switzerland
PMID:20687950 biotools:mltreemap, OMICS_01457 https://bio.tools/mltreemap SCR_004792 Phylogenetic analysis of metagenomics sequence data 2026-08-04 09:41:13 4

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