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http://harvard.eagle-i.net/i/0000012d-b8ed-227f-4882-b08d80000000

Within Children''s Hospital Boston''s Department of Radiology, Diagnostic Radiology offers standard radiography (conventional X-rays) and fluoroscopy, an imaging technique that uses X-rays to create real-time images of the body. We perform more than 135,000 exams each year in Boston and at our satellite locations, which makes us one of the country''s largest general diagnostic centers for children.

Proper citation: CHB Diagnostic Radiology Core (RRID:SCR_009711) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2517-1d49-5617-794280000000

Core facility that provides the following services: Data acquisition service, Data storage service.

The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. The Data Collection Core will provide expert services including: study forms design and implementation; training in all aspects of using TELEform software; database construction and exporting / preparing data for statistical applications such as SAS and SPSS; and technical assistance with scanners and computers running electronic form capture process.

Proper citation: BIDMC eData Collection Core (RRID:SCR_009679) Copy   

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http://harvard.eagle-i.net/i/0000012a-2512-776b-5617-794280000000

Computed Tomography (CT) at Children''s Hospital Boston helps doctors quickly answer urgent questions about your child''s health. In just seconds or minutes, CT scans can produce incredibly detailed, three-dimensional images of your child''s bone, tissue and blood vessels. CT exams in our powerful multi-detector scanners are quick, painless and non-invasive. Located at two locations: Boston and Waltham. Should be contacted about scanner technology, image acquisition, etc., but not for actual access to the facility.

Proper citation: CHB Computed Tomography Core Imaging Facilities (RRID:SCR_009710) Copy   

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http://harvard.eagle-i.net/i/0000012a-2519-e7a3-5617-794280000000

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

Proper citation: BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) Copy   

•   Source: SciCrunch Registry

http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

Proper citation: BIDMC Mass Spectrometry Core (RRID:SCR_009672) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-09f6-d7d6-6a45-990480000000

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

Proper citation: BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-1465-5617-794280000000

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

Proper citation: CHB Cellular Imaging Core (RRID:SCR_009671) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c7-c357-db6e-7a3f80000000

Core facility that provides the following services: Rapid golgi staining service, Luxol fast blue service, Electron microscopy service, Electron microscopy embedding service, Electron microscopy sectioning service, H&E and cresyl violet staining service, Golgi Cox service, Cryostat, vibratome, and microtome usage service, Ultramicrotome usage service. The core allows investigators to perform diverse types of histological studies at several levels, including light and electron microscopy. Furthermore, since mental retardation may not be associated with structural abnormalities visible at the light microscopic level, analysis of protein expression by immunohistochemistry and gene expression by in situ hybridization are also facilitated by this Core.

Proper citation: CHB Cellular Neuroscience Core Laboratory (RRID:SCR_009708) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-9ff6-5676-4882-b08d80000000

Core facility that provides the following services: Flow cytometry analysis service, Cell cycle analysis, Cell sorting service, Side population cell sorting, Zebrafish cell sorting and analysis. The Stem Cell Core Facility has been part of the IDDRC center for more than 30 years fostering collaboration and innovation among IDDRC investigators and members of the academic research community. It was used to develop chromosome sorting for human chromosome specific recombinant libraries and these techniques were utilized by others to generate large scale libraries for the early genome project. The facility was the first to develop cell sorting of fetal cells in the maternal circulation as a means to detect fetal genetic abnormalities. Throughout its history the Stem Cell Core has provided careful and accurate cell cycle analysis via DNA content analysis using Hoechst dye uptake. This service is still used today by investigators. The facility was among the first to take advantage of the ability to express GFP in cells transfected with vectors and induced to express GFP in transgenic animals conditionally expressing a specific gene promoter. This ability allowed IDDRC investigators to isolate neurons, muscle cells and other cell types which express GFP from those which do not. IDDRC investigators were among the first to subsequently culture sorted neurons. Based on the extensive experience of the core using Hoechst dye for cell cycle analysis, the core was able to help IDDRC investigators prepare side population cells (tissue derived potential multipotent progenitor cells) based on Hoechst dye efflux. These methods have allowed the isolation of different muscle side population cells and have facilitated experiments that aim to use the cells for treating muscle disease. The interactive and collaborative nature of the core has fostered these developments, and the interests of the core director, advisory committee, manager and IDDRC investigators will continue to make this core as innovative in the future as it has been in the past. The overall goal of the Stem Cell Core Facility is to provide both IDDRC and non-IDDRC researchers comprehensive analytical flow cytometry and cell sorting services in a timely, dependable and cost-effective manner., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CHB Cell Sorter Core (RRID:SCR_009706) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-a940-5617-794280000000

Core facility that provides the following services: Gene targeting service, Transgenics service. The Transgenic Core centralizes the production of genetically altered mice for MRRC investigators in a cost-effective and efficient manner. The Core also provides expert assistance in the additional areas required for generating genetically altered mice, including transgene and targeting construct production, and transgenic mouse colony management. Core personnel are available to train investigators in all of the techniques required for the generation of genetically modified mice.

Proper citation: CHB Transgenic Core Laboratory (RRID:SCR_009707) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82ef-5677-1a88-e81c80000000

Core facility that provides the following services: Assay analysis consulting services, Sandwich immunoassays, Competitive immunoassays, Hormone immunoassay service, Inflammation marker immunoassay service, Oxidative stress immunoassay service, Cancer marker immunoassay service, Kidney function immunoassay service, Cardiovascular immunoassay service, DNA damage/repair assay service, Metabolic profile assay service, Apoptosis/ survival pathways assay service. Since its inception fifteen years ago, the Technology Core Laboratory has surpassed its goals in new assay development and assay refinement. It has provided top-quality services, been innovative in developing new assays, and has encouraged collaborations between molecular biologists and clinical investigators. This core laboratory has an outstanding record of accomplishments and has supported many high-impact, peer-reviewed publications.

Proper citation: CDU Metabolic and Oxidative Stress Core Laboratory (RRID:SCR_009702) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82f1-6b82-1a88-e81c80000000

A 3,000 square foot Exercise Physiology Lab is located in the ERC Business Park approximately one mile from KDMC. It is fully equipped with Keiser pneumatic resistance training equipment, free weights, treadmills, stationary exercise cycles, as well as state-of-the-art, computerized equipment for measuring muscle performance, cardiopulmonary response, and body composition. These tools are available for utilization by investigators working the field of health disparities related to endocrine metabolism and exercise physiology.

Proper citation: CDU Exercise Physiology Laboratory (RRID:SCR_009700) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-020d-f054-b2b9-4d8780000000

Core facility that provides the following services: DNA extraction from whole blood, saliva, isolated cell pellet, RNA extraction from whole blood with PaxGene tubes, Lymphoblast transformation, Isolation and cryo-preservation of white blood cells. The BioSample Services Facility (BSF) provides sample handling and preparation resources to investigators in the Partners research community. Our goal is to efficiently and effectively process specimens enabling the generation of high quality data via down stream processes. All projects containing subject samples and submitted to the BSF for handling must be IRB approved in advance. All specimens must be entered into our Laboratory Information Management System (GIGPAD) prior to delivery to the BSF. Our staff will work with you to design an implementation plan that would best fit your research needs.

Proper citation: Harvard PCPGM Biosample Services Facility (RRID:SCR_009856) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a527-eb04-bf4c-ca4080000000

Core facility that provides the following services: Imaging training, Imaging equipment access. The Molecular Imaging Laboratory?s research focuses on small animal in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. In particular, we are interested in using molecular imaging techniques to study mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small animal disease models.

Proper citation: Howard Imaging Core Facility: Molecular Imaging Laboratory (RRID:SCR_009857) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c1a-059b-55da-381e80000000

Core facility that provides the following services: Microscope access service, Microscope training service. Confocal and multiphoton are modern fluorescence techniques in microscopy for generating optical sections from live or fixed biological specimens. In general, both techniques employ a point scanning and point detecting design. The confocal microscope achieves point detection by using a confocal pinhole to block off out-of-focus emission from the specimen. The multiphoton microscope, on the other hand, generates intrinsic point emission directly from the in-focus spot, thereby eliminating the need for a confocal pinhole. Subsequent scanning of the entire field of view results in an optical section. Computer reconstruction of serial optical sections, collected at consecutive axial (z) positions, can reveal the spatial localization of cells and tissues (sometime subcellular molecules) in 3D. The ability to see biochemical processes in live cells, in real time, sheds light on the vastly complex molecular world of cells and may allow IDI scientists to identify new targets for drugs that will treat exposure to dangerous toxins and bacteria as well as fight a wide variety of diseases.

Proper citation: Harvard PCMM Optical Microscopy Core (RRID:SCR_009854) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-0214-5945-b2b9-4d8780000000

The Partners Biorepository for Medical Discovery (PBMD), operated by the Partners HealthCare Center for Personalized Genetic Medicine, aims to foster collaborations among investigators, physicians and patients seen at Partners HealthCare institutions. This Partners-wide project is at the forefront of developing the tools needed to expedite the discovery and introduction of new ways to fight disease. As we advance the age of personalized medicine, it is critical that physicians and scientists work with large numbers of patients to advance the delivery of healthcare. The Biorepository provides an opportunity for patients to interact with investigative studies ? safely, securely and privately ? in ways that could have an enormous benefit for us all. The Biorepository continues in a development phase, and is actively working with a number of groups at BWH and MGH who are consenting patients for clinical and translational research studies. Samples are maintained in an institution-wide repository which is a growing resource available to Partners investigators and research groups.

Proper citation: Harvard PCPGM Biorepository for Medical Discovery (RRID:SCR_009855) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-e1a8-0ec0-2162-17a280000000

Core facility that provides the following services: Introduction to the GE In Cell Analyzer 1000 for High Content Analysis (HCA). In collaboration with GE Healthcare Bio-sciences, the NeuroDiscovery Center has established a program centered around the IN Cell Analyzer 1000 - a flexible and easy to use sub-cellular analysis system suitable for medium-throughput screening, assay development and basic research. Based in the NeuroDiscovery Laboratory for Drug Discovery in Neurodegeneration, the IN Cell Analyzer 1000 is available for use by NeuroDiscovery members. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome enquiries from all investigators.)

Proper citation: Harvard NeuroDiscovery Center - Cell-based Assays Core (RRID:SCR_009852) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-e198-9f3f-2162-17a280000000

High quality statistical support is important in the preparation of grant applications or study protocols for clinical trials. Such support typically is not readily available to investigators who are new to clinical trials. To address this weakness, the NeuroDiscovery Center provides consulting and collaborative services to its members who are engaged in clinical research applicable to neurodegenerative disease.

Proper citation: Harvard NeuroDiscovery Center - Biostatistics Consultation (RRID:SCR_009850) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c4-8067-db6e-7a3f80000000

Core facility that provides the following services: Transgene microinjection service, Embryonic stem cell gene targeting service, Blastocyst injection service, Cryopreservation of embryos and sperm, Genotyping service, Mouse consulting service. The Genome Modification Facility (GMF) provides transgenic, gene targeting, and other services to investigators of Harvard University and its affiliated institutions, as well as to investigators within the US and abroad. The GMF performs microinjections of DNA into fertilized embryos to generate transgenic mice, DNA transfection into ES cells for the creation of recombinant ES cell clones, injection of gene-targeted ES cells into host blastocysts to generate gene knock-out or knock-in mice, teratoma formation studies, and other related ES cell-based services. Other services include cryopreservation of mouse sperm and embryos, in vitro fertilization (IVF), recovery of cryopreserved mouse sperm and embryos, rederivation of pathogen free mouse lines, and derivation ES cell lines from wild type and mutant mice with a variety of genetic backgrounds. Our staff provides general consultations on experimental designs and vectors for gene modification-related projects, DNA preparation, recombinant ES clones, mouse genotyping, colony breeding and husbandry. We can also customize services as requested to support development of animal models of human diseases.

Proper citation: Harvard Genome Modification Facility Harvard University (RRID:SCR_009849) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-021d-e404-b2b9-4d8780000000

Core facility that provides the following services: ABI Prism Taqman Allelic Discrimination Assay, OpenArray SNP genotyping, Illumina genotyping, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping analysis, Illumina methylation analysis. The Partners Genotyping Facility, part of the Partners HealthCare Center for Personalized Genetic Medicine (PCPGM), provides flexible, high quality, high-throughput SNP genotyping to the Harvard-Partners research community, including Harvard Medical School, hospitals in the Partners HealthCare network, investigators in the Dana-Farber-/ Harvard Cancer Center, and the Harvard School of Public Health. The portfolio of Genotyping methods at PCPGM now includes Illumina, TaqMan and TaqMan OpenArrays. Note: DF/HCC members will receive the DF/HCC discount on both genotyping and sequencing services from our facility

Proper citation: Harvard PCPGM Genotyping Facility (RRID:SCR_009846) Copy   

•   Source: SciCrunch Registry