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http://www.med.unc.edu/cgibd/cores/histology

Core facility that provides a full range of histology services, encompassing routine and specialized grossing, tissue processing, paraffin embedding, microtomy, H&E and special staining, and immunohistochemistry. It also offers image analysis and consultations to CGIBD members and non-members.

Proper citation: University of North Carolina Center for Gastrointestinal Biology and Disease Histology Core (RRID:SCR_015614) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/molecular/core_morphology.shtml

Core facility that provides histological services, equipment usage, and technical expertise to digestive and liver research projects.

Proper citation: University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core (RRID:SCR_015618) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/molecular/core_molecular.shtml

Core facility that provides services that will enhance the analysis of both host and microbial biological processes as well as facilitate translation into the clinical arena via human subject research.

Proper citation: University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Host-Microbial Analytic and Repository Core (RRID:SCR_015620) Copy   

•   Source: SciCrunch Registry

https://hddc.hms.harvard.edu/epithelial-cell-and-mucosal-immunology

Core facility that provides the infrastructure, biologic resources, expertise, and training for cross-disciplinary research on epithelial biology and immune function in mucosal surfaces and solid organs of the GI tract.

Proper citation: Harvard Digestive Diseases Center Biomedical CORE C: Epithelial Cell and Mucosal Immunology (RRID:SCR_015588) Copy   

•   Source: SciCrunch Registry

http://livercenter.ucsf.edu/immunology-core

Core that takes advantage of local expertise and resources to enable Center members to analyze cell populations in mouse or human livers. It performs complex analyses on small numbers of human cells, such as those obtained from liver biopsies.

Proper citation: UCSF Liver Center Immunology Core (RRID:SCR_015596) Copy   

•   Source: SciCrunch Registry

http://livercenter.ucsf.edu/clinical-translational-core

Core that supports study design to sample procurement and storage, to data analysis and presentation, and also focuses on research involving human subjects.

Proper citation: UCSF Liver Center Clinical & Translational Core (RRID:SCR_015598) Copy   

•   Source: SciCrunch Registry

http://mmoc.med.umich.edu/CoreIntegrativeBiostatisticsInformatics.php

Core facility whose services include expertise in experimental design and modeling for preclinical, clinical and translational research studies that integrate clinical, molecular, neurobehavioral and other phenotype data. It also offers support for data acquisition and analysis by the MMOC phenotyping Cores and Investigational Weight Management Clinic, expertise in database construction, maintenance and security relevant to investigators studies, and development and use of database and software tools for information organization and visualization of tightly-linked multiscale data for T1 translation of research knowledge relevant to obesity.

Proper citation: University of Michigan Nutrition and Obesity Research Center Integrative Biostatistics and Informatics Core (RRID:SCR_015478) Copy   

•   Source: SciCrunch Registry

http://livercenter.ucsf.edu/pathology-imaging-core

Core that provides services from routine liver histology to complex microscopy and image analysis.

Proper citation: UCSF Liver Center Pathology & Imaging Core (RRID:SCR_015599) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/uwnorc/core-facilities/administrative-and-enrichment-core/

Core that is responsible for the overall administrative coordination of the NORC. It also administers the Biostatistics Subcore, Pilot and Feasibility Program, and Enrichment Seminar Series.

Proper citation: University of Washington Nutrition and Obesity Research Center Administrative and Enrichment Core (RRID:SCR_015471) Copy   

•   Source: SciCrunch Registry

https://hddc.hms.harvard.edu/clinical-translational-research-program

Core facility that supports basic, translational, and clinical research in the digestive diseases by providing access to human materials and resources in statistics and study design. Its services promote translation of basic research advances into improved clinical care by offering fresh and archived human specimens, associated clinical metadata, biostatistics and aid in study design.

Proper citation: Harvard Digestive Diseases Center Clinical Translational Research Program (RRID:SCR_015592) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/uwnorc/core-facilities/analytic-core/

Core that provides affiliated investigators with access to nutritional assays, new methods development, and consultation services. Services also include quantitative measures of nitrogen-containing compounds, carbohydrates and related compounds, lipids and related compounds, and more.

Proper citation: University of Washington Nutrition and Obesity Research Center Analytic Core (RRID:SCR_015470) Copy   

•   Source: SciCrunch Registry

http://www.uchicagoddrcc.org/research-cores/administrative-core

Core that has oversight of the other four cores of University of Chicago's Digestive Disease Research Core Center and determines the center's overall direction.

Proper citation: University of Chicago Digestive Diseases Research Core Center Administrative Core (RRID:SCR_015602) Copy   

•   Source: SciCrunch Registry

http://www.uchicagoddrcc.org/research-cores/host-microbe-core

Core that consists of two components: The Enteric Microbiology and The Gnotobiotic Mouse components. The Enteric Microbiology component offers novel screening and advanced technologies for compositional and functional profiling of the resident microbial communities in the gastrointestinal tract. The Gnotobiotic Mouse component enables investigators to study the effects and causal role of specific microorganisms or profiles in vivo.

Proper citation: University of Chicago Digestive Diseases Research Core Center Host-Microbe Core (RRID:SCR_015603) Copy   

•   Source: SciCrunch Registry

https://joslinresearch.org/drc-cores/molecular-phenotyping-and-genotyping-core

Core facility that supports the study of molecular mechanisms of disease by providing equipment, expertise, and services in molecular phenotyping, including nucleic acid sequence analyses, gene expression, and other "omics" analyses, which would be too specialized or costly for individual laboratories to perform independently. Formerly known as the Advanced Genomics and Genetics Core, the Molecular Phenotyping Core is newly-named in recognition of the expansion of its analytical capacities to reflect not only genetic and genomic analyses but also metabolic phenotyping.

Proper citation: Joslin Diabetes Center Molecular Phenotyping and Genotyping Core (RRID:SCR_015733) Copy   

•   Source: SciCrunch Registry

http://www.med.umich.edu/mgpc/cores/mbc.htm

Core whose services include the following programs: Transgenic Rodent Program, Genome Editing Program, Viral Vector Program, and Integrated Genomics Program.

Proper citation: University of Michigan Center for Gastrointestinal Research Molecular Biology Core (RRID:SCR_015610) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/uwnorc/core-facilities/adipose-tissue-and-obesity-core/

Core that provides affiliated investigators with assistance for in vivo and in vitro studies in both subcutaneous and visceral human adipose tissue. Body and liver fat measurement by DXA and MRI are also provided, as is support for translational studies that assist investigators in the design conduct of clinical obesity research.

Proper citation: University of Washington Nutrition and Obesity Research Center Adipose Tissue and Obesity Core (RRID:SCR_015481) Copy   

•   Source: SciCrunch Registry

https://www.ngvbcc.org/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 11, 2023. Archiving services, insertional site analysis, pharmacology and toxicology resources, and reagent repository for academic investigators and others conducting gene therapy research. Databases and educational resources are open to everyone. Other services are limited to gene therapy investigators working in academic or other non-profit organizations. Stores reserve or back-up clinical grade vector and master cell banks. Maintains samples from any gene therapy related Pharmacology or Toxicology study that has been submitted to FDA by U.S. academic investigator that require storage under Good Laboratory Practices. For certain gene therapy clinical trials, FDA has required post-trial monitoring of patients, evaluating clinical samples for evidence of clonal expansion of cells. To help academic investigators comply with this FDA recommendation, the NGVB offers assistance with clonal analysis using LAM-PCR and LM-PCR technology.

Proper citation: National Gene Vector Biorepository (RRID:SCR_004760) Copy   

•   Source: SciCrunch Registry

http://diabetes.niddk.nih.gov/dm/pubs/control/index.aspx

Clinical study that showed that keeping blood glucose levels as close to normal as possible slows the onset and progression of eye, kidney, and nerve diseases caused by diabetes. EDIC is a follow-up study of people who participated in DCCT. The DCCT involved 1,441 volunteers, ages 13 to 39, with type 1 diabetes and 29 medical centers in the United States and Canada. Volunteers had to have had diabetes for at least 1 year but no longer than 15 years. They also were required to have no, or only early signs of, diabetic eye disease. The study compared the effects of standard control of blood glucose versus intensive control on the complications of diabetes. Intensive control meant keeping hemoglobin A1C levels as close as possible to the normal value of 6 percent or less. The A1C blood test reflects a person''''s average blood glucose over the last 2 to 3 months. Volunteers were randomly assigned to each treatment group. DCCT Study Findings * Intensive blood glucose control reduces risk of ** eye disease: 76% reduced risk ** kidney disease: 50% reduced risk ** nerve disease: 60% reduced risk When the DCCT ended, researchers continued to study more than 90 percent of participants. The follow-up study, called Epidemiology of Diabetes Interventions and Complications (EDIC), is assessing the incidence and predictors of cardiovascular disease events such as heart attack, stroke, or needed heart surgery, as well as diabetic complications related to the eye, kidney, and nerves. The EDIC study is also examining the impact of intensive control versus standard control on quality of life. Another objective is to look at the cost-effectiveness of intensive control. EDIC Study Findings * Intensive blood glucose control reduces risk of ** any cardiovascular disease event: 42% reduced risk ** nonfatal heart attack, stroke, or death from cardiovascular causes: 57% reduced risk

Proper citation: Diabetes Control and Complications Trial (RRID:SCR_006805) Copy   

•   Source: SciCrunch Registry

https://www.baderc.org/cores/metaboliccore/

Core in BADERC that provides services in consultation and teaching, use of DEXA scanner for determination of body fat and/or bone density, and use of Coulter Counter to measure cell number and cell size distribution.

Proper citation: Boston Area Diabetes Endocrinology Research Center Metabolic Physiology and Energy Balance Core Facility (RRID:SCR_008293) Copy   

•   Source: SciCrunch Registry

https://joslinresearch.org/drc-cores/Flow-Cytometry-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core that provides cell sorting and flow cytometry services. Specific services include cell analysis, large object sorting,magnetic cell enrichment, and automatic cell counting.

Proper citation: Joslin Diabetes Center Flow Cytometry Core Facility (RRID:SCR_009878) Copy   

•   Source: SciCrunch Registry