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http://pingstudy.ucsd.edu/

A large multi-site pediatric MRI and genetics data resource to facilitate studies of the genomic landscape of the developing human brain. It includes information about the developing mental and emotional functions of the children to understand the genetic basis of individual differences in brain structure and connectivity, cognition, and personality. Investigators on the project are studying 1400 children between the ages of 3 and 20 years so that links between genetic variation and developing patterns of brain connectivity can be examined. Investigators interested in the effects of a particular gene will be able to search the database for any brain areas or connections between areas that differ as a function of variation in a particular gene, and also to determine if the genes appear to affect the course of brain development at some point during childhood. A data exploration tool has been created for mapping and analyzing MRI data sets collected for PING and related developmental studies. Approved investigators will be able to view raw image sets and derived 3D brain maps of MRI and DTI data, conduct hypothesis testing, and graph brain area measures as they change across the time course of development. PING Cores * Coordinating Core: Functions include project management, screening of participants and maintaining the database * Neuroimaging Core: applying a standardized high-resolution structural MRI protocol involving 3-D T1-weighted scans, a T2-weighted volume, and a set of diffusion-weighted scans with multiple b values and diffusion directions, scans to estimate MRI relaxation rates, and gradient echo EPI scans for resting state fMRI. Importantly, adaptive motion compensation, using ����??PROMO����??, a novel real-time motion correction algorithm will be used. Specific PING protocols for each scanner manufacturer: ** PING MRI Protocol - GE ** PING MRI Protocol - Philips ** PING MRI Protocol - Siemens * Assessment Core: Cognitive assessments for the PING project are conducted using the NIH Toolbox for Cognition. * Genomics Core: functions as a central repository for receipt of saliva samples collected for each study participant. Once received, samples are catalogued, maintained, and DNA is extracted using state-of-the-field laboratory techniques. Ultimately, genome-wide genotyping is performed on the extracted DNA using the Illumina Human660W-Quad BeadChip. PING involves 10 sites throughout the country including UCSD, University of Hawaii, Scripps Genomics, UCLA, UC Davis, Kennedy Krieger Institute/Johns Hopkins, Sacker Institute/Cornell University, University of Massachusetts, Massachusetts General Hospital/Harvard, and Yale. Families who may want to participate in the study, or others who want to know more about it, may email questions to ping (at) ucsd.edu.

Proper citation: Pediatric Imaging Neurocognition and Genetics (RRID:SCR_008953) Copy   

•   Source: SciCrunch Registry

http://recombineering.ncifcrf.gov/

Recombineering (recombination-mediated genetic engineering) is a powerful method for fast and efficient construction of vectors for subsequent manipulation of the mouse genome or for use in cell culture experiments. It is also an efficient way of manipulating the bacterial genome directly. Recombineering is a method based on homologous recombination in E. Coli using recombination proteins provided from ? phage. Our bacterial strains contain a defective ? prophage inserted into the bacterial genome. The phage genes of interest, exo, bet, and gam, are transcribed from the ?PL promoter. This promoter is repressed by the temperature-sensitive repressor cI857 at 32C and derepressed (the repressor is inactive) at 42C. When bacteria containing this prophage are kept at 32C no recombination proteins are produced. However, after a brief (15 minutes) heat-shock at 42C a sufficient amount of recombination proteins are produced. exo is a 5''-3'' exonuclease that creates single-stranded overhangs on introduced linear DNA. bet protects these overhangs and assists in the subsequent recombination process. gam prevents degradation of linear DNA by inhibiting E. Coli RecBCD protein. Linear DNA (PCR product, oligo, etc.) with sufficient homology in the 5'' and 3'' ends to a target DNA molecule already present in the bacteria (plasmid, BAC, or the bacterial genome itself) can be introduced into heat-shocked and electrocompetent bacteria using electroporation. The introduced DNA will now be modified by exo and bet and undergo homologous recombination with the target molecule. The method is so efficient that co-electroporation of a supercoiled plasmid and a linear piece of DNA into heat-shocked, electrocompetent bacteria will work as well.

Proper citation: Recombineering Information (RRID:SCR_008556) Copy   

•   Source: SciCrunch Registry

http://biobehavioural.blogspot.com/

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. Biobehavioral blog on research and medicine as a continuum from biological mechanisms to behavioural phenomena., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Biobehavioral (RRID:SCR_008710) Copy   

•   Source: SciCrunch Registry

http://mips.helmholtz-muenchen.de/funcatDB/

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 19, 2019. The Functional Catalogue is an annotation scheme for the functional description of proteins of prokaryotic and eukaryotic origin. Taking into account the broad and highly diverse spectrum of known protein functions, the FunCat consists of 28 main functional categories (or branches) that cover general fields like cellular transport, metabolism and cellular communication/signal transduction. The main branches exhibit a hierarchical, tree like structure with up to six levels of increasing specificity. In total, the FunCat version 2.1 includes 1362 functional categories. This general concept was retained since the annotation of the Saccharomyces cerevisiae genome with only 4 revisions and later on also proved to be well suited for the annotation of genomes from different domains of life (Ruepp et al. 2004). The present and previous versions as well as a version mapping file of the FunCat and annotation data of our core projects can be downloaded via FTP. The MIPS Functional Catalogue Database provides a search tool to browse and search the Functional Categories including the FunCat Number, description, EC number, GO number or keywords associated with the categories. All FunCat annotated proteins and the amount of Co-annotated-FunCats can be retrieved starting with a specific category in a selected organism. A statistical survey of the functional distribution of a given set of genes/entries, e. g. a set of genes with up-regulated expression under a certain condition can be retrieved.

Proper citation: MIPS FunCat (RRID:SCR_008709) Copy   

•   Source: SciCrunch Registry

http://www.nordgen.org/index.php/en/content/view/full/467

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 18,2023.

Proper citation: Nordic Genetic Resource Center (RRID:SCR_008706) Copy   

•   Source: SciCrunch Registry

http://gump.qimr.edu.au/general/daleN/SNPSpD/

SNPSpD is a method of correcting for non-independance of single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of LD between SNP''s. Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor loadings after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region.

Proper citation: Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD) (RRID:SCR_008621) Copy   

•   Source: SciCrunch Registry

http://empai.iab.keio.ac.jp/

emPAI (exponentially modified protein abundance index), developed by Ishihama et al., is a measure to describe the protein composition in sample solutions. When the total protein amount in the sample is available, emPAI can be converted to the absolute amount of each protein in the sample. emPAI is derived from PAI, which is defined as the number of the observed peptides divided by the number of the observable peptides per protein. We recently found that log (PAI) had linear relationship to the protein amounts, and that emPAI, 10^(PAI)-1, was proportional to the protein amounts for whole cell lysate digested by trypsin. The accuracy of this method was within factor 5, similar or better than determination of abundance by protein staining

Proper citation: Exponentially Modified Protein Abundance Index (RRID:SCR_008616) Copy   

•   Source: SciCrunch Registry

http://lsid.tdwg.org/

A web based life sciences identifier (LSID) resolution service allows you to view the data and metadata of an LSID with a web browser. This service will display the metadata, formatted as a standard webpage, for any LSID.

Proper citation: LSID Web Resolver (RRID:SCR_009737) Copy   

•   Source: SciCrunch Registry

http://www.danubianbiobank.de/

Not yet vetted by NIF curator

Proper citation: Danubian Biobank Consortium (RRID:SCR_010566) Copy   

•   Source: SciCrunch Registry

http://www.alphagenesisinc.com/#welcomefront

A company which provides nonhuman primate products and bio-research services for the global scientific community. They provide serum, plasma, whole blood, and tissue samples from primates such as the Cynomolgus macaque, the Rhesus macaque, and the African Green. Products based on others species are available upon request.

Proper citation: Alpha Genesis (RRID:SCR_010568) Copy   

•   Source: SciCrunch Registry

http://dtp.nci.nih.gov/branches/npb/open_repository.html

Not yet vetted by NIF curator

Proper citation: NCI National Products Branch (RRID:SCR_010603) Copy   

•   Source: SciCrunch Registry

http://neuromorphometrics.com/?page_id=23

Collection of neuroanatomically labeled MRI brain scans, created by neuroanatomical experts. Regions of interest include the sub-cortical structures (thalamus, caudate, putamen, hippocampus, etc), along with ventricles, brain stem, cerebellum, and gray and white matter and sub-divided cortex into parcellation units that are defined by gyral and sulcal landmarks.

Proper citation: Manually Labeled MRI Brain Scan Database (RRID:SCR_009604) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/transgenic-mouse-models-core

Core assists investigators with developing genetically engineered rodent models of human diseases for studying mutant genes and investigating molecular mechanisms underlying pathological processes.

Proper citation: OHSU Animal Model Support Core Facility (RRID:SCR_009994) Copy   

•   Source: SciCrunch Registry

http://wren.bcf.ku.edu/

The Autism Genetic Database currently contains the full list of autism susceptibility genes as well as all Copy Number Variations (CNVs) found to have a relationship to autism. Additionally, all noncoding RNA molecules (snoRNA, miRNA, and piRNA) and chemically induced fragile sites are stored as well. This information is currently accessible via an in-house human genome browser focusing specifically on the chromosomal features associated with autism, and in a tabular format broken down by chromosome. Genome Browser:A genome browser that displays the genes, CNVs, ncRNAs and fragile sites in an easily accessible graphical visualization tool Tabular Data Display:A tabular data display that allows the user to observe the chromosomal spatial relationship between the genes, CNVs, ncRNAs and fragile sites. This also provides links to Entrez and pubmed for each gene, as well as miRBase for miRNAs, snoRNA-LBME-db for snoRNAs, and piRNABank for piRNAs.

Proper citation: Autism Genetic Database (RRID:SCR_010545) Copy   

•   Source: SciCrunch Registry

http://www.brc.riken.go.jp/lab/cell/english/

Not yet vetted by NIF curator

Proper citation: Riken BRC Cell Bank (RRID:SCR_010553) Copy   

•   Source: SciCrunch Registry

https://www.twbiobank.org.tw/new_web_en/index.php

Taiwan Biobank intends to conduct large-scale cohort studies and case-control studies on local diseases. The cohort study will call for 200,000 volunteers, while the case-control study will invite 100,000 patients with the 10 to 15 most common diseases. These studies will enable Taiwan Biobank to identify the disease-causing factors and mechanisms of common diseases to facilitate the development of better treatment and prevention, reduce the cost of medical treatment and make it possible to achieve the goal of improving the island nation’s health.

Proper citation: Taiwan Biobank (RRID:SCR_010557) Copy   

•   Source: SciCrunch Registry

http://bis.zju.edu.cn/DaTo/

A biological database and software tool catalog based on text mined and human annotated url mentions in PubMed abstracts. Data are annotated as to the author''''s country of origin and url status is checked.

Proper citation: DaTo (RRID:SCR_010280) Copy   

•   Source: SciCrunch Registry

http://www.citeab.com/

Citation-ranked antibody search engine that provides a simple way to find antibodies that work. They use the number of citations as a transparent method to rank antibodies. Nobody can pay to be ranked higher. They are always looking for more commercial and academic antibodies to make CiteAb better. There is no charge to list.

Proper citation: CiteAb (RRID:SCR_009653) Copy   

•   Source: SciCrunch Registry

https://www.tycho.pitt.edu/

Database to advance the availability and use of public health data for science and policy making that includes data from all weekly notifiable disease reports for the United States dating back to 1888. Additional U.S. and international data will be released twice yearly.

Proper citation: Project Tycho (RRID:SCR_010489) Copy   

•   Source: SciCrunch Registry

http://www.accessdata.fda.gov/scripts/opdlisting/oopd/index.cfm

Database of Orphan Drug Product designations. Searches may be run by entering the product name, orphan designation, and dates. Results can be displayed as a condensed list, detailed list, or an Excel spreadsheet.

Proper citation: Search Orphan Drug Designations and Approvals (RRID:SCR_010256) Copy   

•   Source: SciCrunch Registry