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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease Resource Report Resource Website 1+ mentions |
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (RRID:SCR_000690) | CRISP | resource, clinical trial | A five-year prospective cohort study following 240 patients who have autosomal-dominant polycystic kidney disease (PKD) to determine whether changes in anatomic characteristics of their kidneys as measured by magnetic resonance imaging will be useful in providing surrogate measures for disease progression. CRISP's overall goal is to develop methods that would facilitate shortening the observation period necessary to determine efficacy of treatment interventions in PKD patients. Specific goals of this study are to: * Quantify cyst growth and ascertain severity of renal parenchymal involvement by sequential measurement of total kidney volume and the ratio of intact parenchyma to renal parenchyma occupied by cysts over time * Establish useful clinical correlations of imaging data with other markers of disease progression * Identify and test other potential markers or indices of disease progression, for example, assessment of loss of heterozygosity of renal cells shed in the urine, or other markers, in cohorts of patients with PKD * Gain information about the cost-effectiveness, patient acceptability, and advantages and disadvantages of different imaging techniques used serially in patients with PKD. Some experience has been gained in establishing that repeat imaging of the same PKD patient, using these techniques, yields reproducible estimates of kidney size and the proportion of renal parenchyma occupied by cysts. MRI may also have the advantage of permitting simultaneous estimation of GFR. Ultrasound has the advantage of being more cost-effective and perhaps more acceptable to patients for repetitive studies, but the measurements may be less accurate and reproducible. Nonetheless, there is very limited experience in applying these techniques to follow progression of the renal disease. Development of improved, reproducible imaging methods that assess cyst growth and provide markers of disease progression could markedly improve the feasibility of clinical trials. Participating clinical centers are Emory University, the Mayo Clinic, University of Kansas, and the University of Alabama at Birmingham. The data coordinating and imaging analysis center is at Washington University. (PI has since moved to University of Pittsburgh) The study found that kidney enlargement resulting from the expansion of cysts is continuous, quantifiable, and associated with the decline of renal function. Cystic expansion occurs at a consistent rate per individual, although it is heterogeneous in the population, and that larger kidneys are associated with more rapid decrease in renal function. These anatomic characteristics of patient kidneys may provide useful surrogate measures for disease progression, and hence enhance the development of targeted therapies for autosomal dominant PKD. CRISP III is a five-year prospective cohort study to follow ~170 remaining autosomal dominant polycystic kidney disease (ADPKD) patients who were part of the original CRISP cohort study. CRISP III will verify and extend the preliminary observations of CRISP to determine the extent to which quantitative (kidney volume and blood flow, and hepatic and kidney cyst volume) or qualitative (cyst distribution and character) structural parameters predict renal insufficiency and develop and test new metrics to quantify and monitor disease progression. Urine metabolites and the genome will be correlated with the progression of disease to look for new, predictive disease biomarkers. This information from CRISP III will help determine if the kidney enlargement, blood flow, cyst distribution, or urine metabolites can function as an informative surrogate measure for disease progression. | mri, kidney volume, cyst volume, kidney, renal function, disease progression, measure, blood flow, hepatic cyst volume, kidney cyst volume, renal insufficiency, urine metabolite, surrogate measure, clinical, intervention |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Pittsburgh; Pennsylvania; USA |
Polycystic kidney disease, Autosomal dominant polycystic kidney disease | NIDDK 5U01DK056961 | THIS RESOURCE IS NO LONGER IN SERVICE | nlx_152795 | SCR_000690 | Consortium of Radiologic Imaging Study of PKD | 2026-08-03 09:31:08 | 3 | |||||
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Medical Therapy of Prostatic Symptoms Resource Report Resource Website 1+ mentions |
Medical Therapy of Prostatic Symptoms (RRID:SCR_001556) | MTOPS | resource, clinical trial | Multi-center double-masked, placebo-controlled randomized clinical trial designed to evaluate the long-term efficacy of finasteride, or doxazosin, or the combination of both, in delaying or preventing the clinical progression of symptomatic benign prostatic hyperplasia (BPH). MTOPS was the largest and longest study to test whether drug therapy can prevent or delay the noncancerous growth of the prostate. A unique feature of MTOPS that has not been done in prior studies of pharmacotherapy of BPH is the biopsy substudy. A total of 1,082 volunteers from the 2,931 participants randomized during the full-scale phase are currently participating in this substudy. Biopsies of the prostate will be obtained on these volunteers at predetermined times during the course of the trial to evaluate the status of the prostate at key event times. The purpose of the substudy was to provide additional information regarding the histopathobiology of BPH and to test existing biomarkers for their prognostic ability regarding response to drug therapy. | male, adult human, prostate, placebo, finasteride, doxazosin, drug, treatment, prostate biopsy, tissue, prostate tissue, intervention, biomaterial supply resource, biomarker, serum |
is listed by: One Mind Biospecimen Bank Listing is listed by: ClinicalTrials.gov is affiliated with: MTOPS Prostate Samples Analysis Consortium has parent organization: George Washington University; Washington D.C.; USA |
Benign prostatic hyperplasia | NIDDK U01DK46472 | Free, Freely available | nlx_152863 | SCR_001556 | Medical Therapy of Prostatic Symptoms (MTOPS) | 2026-08-03 09:31:23 | 1 | |||||
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National Diabetes Education Program Resource Report Resource Website 10+ mentions |
National Diabetes Education Program (RRID:SCR_001477) | NDEP | resource, training resource | Federal government public education program that promotes diabetes prevention and control. They aim to reduce the morbidity and mortality associated with diabetes and its complications. The NDEP is jointly sponsored by the National Institutes of Health and the Centers for Disease Control and Prevention and over 200 partner organizations. Target audiences include people with diabetes and those at risk, including the racial and ethnic populations disproportionately affected by the disease, health care providers and payers and purchasers of health care. | treatment, outcome, diabetes, diagnosis, prevention, blood glucose level, complication, education, disease-related portal |
is listed by: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Type 1 diabetes, Type 2 diabetes, Diabetes | NIDDK N02DK72927-8-0-1 | Free, Freely available | nlx_152708 | SCR_001477 | 2026-08-03 09:31:20 | 38 | ||||||
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Look AHEAD Resource Report Resource Website 10+ mentions |
Look AHEAD (RRID:SCR_001490) | Look AHEAD | resource, clinical trial | 16-center, randomized clinical trial investigating the long-term health consequences of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity in overweight volunteers with type 2 diabetes. The Look AHEAD cohort comprises approximately 5,000 overweight or obese participants with type 2 diabetes, aged 45-76. Participants were randomized to one of two interventions: an intensive lifestyle intervention designed to produce and sustain weight loss over the long term or a diabetes support and education arm. Participants will be followed for a total of 11 to 13.5 years from randomization. The primary hypothesis is that the incidence rate of the first post-randomization occurrence of a composite outcome, which includes * cardiovascular death (including fatal myocardial infarction and stroke), * non-fatal myocardial infarction, * hospitalized angina, and * non-fatal stroke, over a planned follow-up period of up to 13.5 years will be reduced among participants assigned to the Lifestyle Intervention compared to those assigned to the control condition, Diabetes Support and Education. Look AHEAD will also test for reductions in the incidence of three secondary composite outcomes and examine the effect of the intervention on cardiovascular disease risk factors, diabetes control and complications, general health, and quality of life, and psychological outcomes. The cost and cost-effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed. The Look AHEAD intensive lifestyle intervention ended September, 2012. Participants continue to be followed to determine the long-term effects of the intervention on health outcomes. | weight loss, caloric intake, physical activity, health outcome, long-term effect, longitudinal, intervention, late adult human, middle adult human, cardiovascular disease, risk factor, diabetes control, diabetes complication, health, quality of life, psychological outcome, clinical |
is listed by: NIDDK Information Network (dkNET) has parent organization: Wake Forest University; North Carolina; USA |
Type 2 diabetes, Overweight, Control | NIDDK U01DK057136 | Restricted | nlx_152745 | https://www.lookaheadtrial.org/public/home.cfm | SCR_001490 | Action for Health in Diabetes, Look AHEAD - Action for Health in Diabetes | 2026-08-03 09:31:21 | 46 | ||||
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Frequent Hemodialysis Network Daily Trial Resource Report Resource Website |
Frequent Hemodialysis Network Daily Trial (RRID:SCR_001527) | FHN Daily Trial | resource, clinical trial | Randomized controlled clinical trial to understand how increasing hemodialysis to six times a week from the standard of three times a week may result in improved heart health. Subjects were recruited from dialysis units associated with designated Clinical Centers in the U.S. and Canada and followed for 1 year. Subjects will be randomized to either conventional hemodialyis Daily HD delivered for at least 2.5 hours (typically 3 to 4 hours), 3 days per week, or to more frequent hemodialysis delivered for 1.5 - 2.75 hours, 6 days per week. The study has two co-primary outcomes: 1) a composite of mortality with the change over 12 months in left ventricular mass by magnetic resonance imaging, and 2) a composite of mortality with the change over 12 months in the SF-36 RAND physical health composite (PHC) quality of life scale. In addition, main secondary outcomes have been designated for each of seven outcome domains: 1) cardiovascular structure and function (change in LV mass), 2) health-related quality of life/physical function (change in the PHC), 3) depression/burden of illness (change in Beck Depression Inventory), 4) nutrition (change in serum albumin), 5) cognitive function (change in the Trail Making Test B), 6) mineral metabolism (change in average predialysis serum phosphorus), and 7) clinical events (rate of non-access hospitalization or death). Hypertension and anemia are also main outcome domains, but without designation of single first priority outcomes. | hemodialysis, cardiovascular, kidney, heart |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is related to: Frequent Hemodialysis Network Nocturnal Trial has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Hemodialysis, End Stage Renal Disease | NIDDK | PMID:21091062 PMID:17164834 PMID:17699439 |
Free, Freely available | nlx_152828 | https://www.niddk.nih.gov/news/for-reporters/frequent-hemodialysis-network-daily-trial/Pages/default.aspx | SCR_001527 | Frequent Hemodialysis Network (FHN) Daily Trial | 2026-08-03 09:31:21 | 0 | |||
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Viral Resistance to Antiviral Therapy of Chronic Hepatitis C Resource Report Resource Website |
Viral Resistance to Antiviral Therapy of Chronic Hepatitis C (RRID:SCR_001553) | Virahep-C | resource, clinical trial | Study designed to test the hypothesis that African-Americans respond less well to combination pegylated interferon and ribavirin therapy than Caucasian-Americans who have chronic hepatitis C genotype 1 and who were not previously treated with either interferon or ribavirin. Reasons for differences in response, regardless of race, will be studied. All patients were treated with combination therapy of pegylated interferon and ribavirin for 48 weeks, and were followed for an additional 48 week safter cessation of therapy. 400 patients, half African-American and half Caucasian American, from 8 clinical centers with the goals of establishing rates of response to optimal current therapy in the two ethnic groups, identify factors predictive of response, establish patterns of viral kinetics in response to antiviral therapy, and test hypotheses concerning viral and host factors determining response to therapy. Four ancillary studies designed to elucidate biological and virological basis for non-response are also included in Virahep-C. Additionally, the study has central facilitates for pathology, the virological testing laboratory and a serum/tissue repository. | african-american, pegylated interferon, drug, ribavirin, caucasian-american, chronic hepatitis c genotype 1, biomaterial supply resource, efficacy, treatment, adult human, male, female, interferon, resistance, antiviral therapy, serum, tissue |
is listed by: One Mind Biospecimen Bank Listing is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources has parent organization: University of Pittsburgh; Pennsylvania; USA |
Chronic hepatitis C, Hepatitis C virus | NIDDK U01DK60329 | Free, Freely available | nlx_152861 | http://www.edc.gsph.pitt.edu/virahepc/, http://www.virahepc.org/ | SCR_001553 | Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C (Virahep-C), Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C | 2026-08-03 09:31:23 | 0 | ||||
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TINSAL-T2D Resource Report Resource Website 1+ mentions |
TINSAL-T2D (RRID:SCR_001546) | TINSAL-T2D, TINSAL-T2D-II | resource, clinical trial | Nationwide, randomized, double blind, multi-center research study to determine whether the drug salsalate, a member of the commonly used Non-Steroidal Anti-Inflammatory Drug (NSAID) class, is effective in lowering sugars in patients with type 2 diabetes. The study is conducted in two stages. The primary objective of the first stage is to select a dose of salsalate that is both well-tolerated and demonstrates a trend toward improvement in glycemic control. The primary objective of Stage 2 of the study is to evaluate the effects of salsalate on blood sugar control in diabetes; the tolerability of salsalate use in patients with type 2 diabetes (T2D); and the effects of salsalate on measures of inflammation, the metabolic syndrome, and cardiac risk. | salsalate, drug, intervention, treatment, hba1c, inflammation, obesity, metabolic syndrome, adult human, male, female, non-steroidal anti-inflammatory drug, diabetes management, placebo, glycemic control |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: Joslin Diabetes Center |
Type 2 diabetes, Inflammation, Metabolic syndrome, Cardiac disease, Obesity | NIDDK 5R01DK095327 | PMID:20231565 PMID:17959861 |
Free, Freely available | nlx_152855 | https://clinicaltrials.gov/ct2/show/NCT00392678 | http://www.tinsal-t2d.org/ | SCR_001546 | Targeting Inflammation Using Salsalate for Type 2 Diabetes-stage II, Targeting INflammation using SALsalate for Type 2 Diabetes | 2026-08-03 09:31:26 | 1 | ||
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Study of Nutrition in Acute Pancreatitis Resource Report Resource Website |
Study of Nutrition in Acute Pancreatitis (RRID:SCR_001544) | SNAP | resource, clinical trial | Randomized multi-center clinical trial designed to test whether duodenojejunal (DJ) feeding is more effective than nasogastric (NG) feeding in providing enteral nutrition to patients with severe acute pancreatitis. SNAP will enroll participants with severe acute pancreatitis admitted to the intensive care unit at eight clinical centers. Upon enrollment, participants are assigned to NG or DJ feeding and managed for up to 28 days or until weaned on to solid food. Follow-up continues until participants are discharged from the hospital or for a maximum of 60 days. Outcomes relate to feeding tolerance and failure, nutritional status, risk for life-threatening pancreatic/systemic complications, and hospital mortality. | duodenojejunal feeding, naso gastric feeding, enteral nutrition, feeding tolerance, outcome, acute pancreatitis, distal jejunal feeding, intervention, nutrition, treatment, adult human, male, female, pancreas |
is listed by: ClinicalTrials.gov is listed by: NIDDK Research Resources is listed by: NIDDK Information Network (dkNET) has parent organization: University of Pittsburgh; Pennsylvania; USA |
Pancreatitis | NIDDK | Free, Freely available | nlx_152854 | SCR_001544 | 2026-08-03 09:31:23 | 0 | ||||||
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Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C Resource Report Resource Website |
Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C (RRID:SCR_006787) | PEDS-C | resource, clinical trial | Multi-center, randomized controlled trial that studied peginterferon therapy, with or without ribavirin, in children with chronic hepatitis C. Approximately 120 children were randomly assigned to receive peginterferon alfa-2a alone or peginterferon with ribavirin for 48 weeks. Samples of blood, genomic DNA, and liver tissue are stored in the NIDDKrepositories. A long-term follow up study of the clinical trial participants is underway. | child, young human, peginterferon alfa-2a, ribavirin, drug, male, female, adolescent, pediatric |
is listed by: One Mind Biospecimen Bank Listing is listed by: NIDDK Research Resources is listed by: NIDDK Information Network (dkNET) is related to: NIDDK Central Repository has parent organization: ClinicalTrials.gov |
Chronic hepatitis C viral infection, Hepatitis C virus | NIDDK | PMID:18042575 | nlx_152846 | http://www.pedsc.org | SCR_006787 | Pegylated Interferon +/- Ribavirin for Children With Hepatitis C, Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C (Peds-C) | 2026-08-03 09:33:14 | 0 | ||||
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Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction Resource Report Resource Website |
Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction (RRID:SCR_006897) | EPISOD | resource, clinical trial | A prospective, double-blind, randomized, sham-controlled, multi-center clinical trial that enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi Dysfunction III (SOD III) as defined by the Rome III criteria. The goal of the study is to asses the value of endoscopic sphincterotomy as a treatment for adult subjects categorized as SOD III suffering from pain after cholecystectomy and to define the role of manometry in treating these patients. | clinical, treatment, intervention, sphincterotomy, pancreatic, pancreas, pancreatitis, biliary, adult human, male, female, manometry |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources |
Cholecystectomy, Sphincter of Oddi Dysfunction | NIDDK | nlx_152824 | http://www.episod.org/ | SCR_006897 | Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction, Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction (EPISOD) | 2026-08-03 09:33:17 | 0 | |||||
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Complementary and Alternative Medicine for Urological Symptoms Resource Report Resource Website |
Complementary and Alternative Medicine for Urological Symptoms (RRID:SCR_007131) | CAMUS | resource, clinical trial | Randomized, multicenter, double blind, placebo controlled clinical trial of phytotherapy for benign prostate symptoms among men. The CAMUS trial will test Saw palmetto in about 369 men. Men who decide to be part of the CAMUS trial will be given one out of two possible treatments at random. One out of every two men would get an inactive placebo treatment. One out of every two men would get Saw palmetto pills. This kind of scientific study is the best way to find out if the plant extracts really work to prevent men with benign prostatic hyperplasia (BPH) from getting worse. During the study, men will not know which of the two treatments they are assigned to. They will be followed very closely by a study team every 12 weeks to see how they are doing. Men in the CAMUS trial will be studied over 72 weeks. Ten clinical centers will participate in the trial. They are located at: Columbia University, NY, NY; New York University, NY, NY; University of Texas Southwestern Medical Center, Dallas, Texas; University of Colorado, Denver, CO; Washington University, St. Louis, MO; Yale University, New Haven, CT; Queens University, Hamilton, Ontario, Canada; Northwestern University, Chicago, IL; University of Maryland, Baltimore, MD; University of California at San Francisco, San Francisco, CA. | phytotherapy, prostate, benign, treatment, male, adult human, saw palmetto, placebo, herbal therapy, middle adult human, late adult human, urology |
is listed by: ClinicalTrials.gov is related to: NIDDK Information Network (dkNET) has parent organization: University of Alabama at Birmingham; Alabama; USA |
Benign prostatic hyperplasia | NCCAM ; NIDDK ; Office of Dietary Supplements ; NIDDK U01DK63795; NIDDK U01DK63797; NIDDK U01DK63825; NIDDK U01DK63835; NIDDK U01DK63866; NIDDK U01DK63833; NIDDK U01DK63862; NIDDK U01DK63840; NIDDK U01DK63883; NIDDK U01DK63831; NIDDK U01DK63778; NIDDK U01DK63788 |
PMID:21954478 PMID:21741692 PMID:21497839 |
nlx_152791 | http://www.camus.uab.edu/camus/html/index.htm |
SCR_007131 | Complementary and Alternative Medicine for Urological Symptoms Clinical Trial, Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Clinical Trial, Complementary and Alternative Medicine for Urological Symptoms (CAMUS) | 2026-08-03 09:33:19 | 0 | ||||
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Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study Resource Report Resource Website |
Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study (RRID:SCR_007130) | FSGS in Children and Young Adults Interventional Study | resource, clinical trial | Network of collaborative research centers that tested the effects of treatment with cyclosporine to treatment with mycophenalate mofetil combined with oral pulse dexamethasone in children and young adults with focal segemental glomerulosclerosis. Efficacy was assessed in terms of induction of remission of proteinuria after 52 weeks of treatment and sustained remission after 26 weeks off treatment. The clinical sites were State University of New York, Stony Brook; Montefiore Medical Center; Seattle Children''''s Medical Center; Medical City Dallas Hospital; and the University of North Carolina. The Cleveland Clinic is the data-coordinating center, and NephCure will fund ancillary studies. | child, early adult, young human, proteinuria, kidney disease, intervention, prednisone, cyclosporine, mycophenalate mofetil, dexamethasone, cyclosporine-a, male, female |
is listed by: ClinicalTrials.gov is affiliated with: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Focal Segmental Glomerulosclerosis, Focal Segmental Glomerulosclerosis Nephrotic Syndrome | NIDDK | nlx_152826 | http://www.fsgstrial.org | SCR_007130 | Focal Segmental Glomerulosclerosis Clinical Trial, Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT), Focal Segmental Glomerulosclerosis (FSGS) Clinical Trial, Focal Segmental Glomerulosclerosis (FSGS) in Children and Young Adults Interventional Study | 2026-08-03 09:33:16 | 0 | |||||
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Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia Resource Report Resource Website |
Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia (RRID:SCR_007126) | MIST for BPH | resource, clinical trial | Randomized clinical trial to determine the efficacy and safety of three treatments for benign prostatic hyperplasia (BPH): transurethral needle ablation (TUNA), transurethral microwave therapy (TUMT), and medical therapy with alfuzosin and finasteride. The study has been terminated. (Inability to recruit required sample size.) | transurethral microwave thermotherapy, transurethral needle ablation, therapy, drug, finasteride, alfuzosin, treatment, clinical, intervention, male, middle adult human, late adult human, prostate |
is listed by: ClinicalTrials.gov is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Benign Prostatic Hyperplasia | NIDDK | nlx_152844 | SCR_007126 | Minimally Invasive Surgical Therapies (MIST) Treatment Consortium for Benign Prostatic Hyperplasia (BPH), Minimally Invasive Surgical Therapy Consortium for Benign Prostatic Hyperplasia | 2026-08-03 09:33:16 | 0 | ||||||
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Renin Angiotensin System Study Resource Report Resource Website 1+ mentions |
Renin Angiotensin System Study (RRID:SCR_013385) | RASS/B-RASS, RASS | resource, clinical trial | Randomized, multicenter, double-blind study to determine if renin angiotensin medications, either losartan (angiotensin II blocker) or enalapril (converting enzyme inhibitor), can prevent or delay the onset of diabetic kidney disease in patients with type 1 diabetic patients who do not have hypertension, diabetic nephropathy, or predictive levels of microalbuminuria. Two hundred eight five patients ages 16-61 with 2-20 yrs of Type 1 Diabetes Mellitus and no renal functional abnormalities were randomized into a parallel, double-blind, placebo-controlled study involving 3 groups (95 patients/group). Each group received an angiotensin-converting enzyme inhibitor (ACEI) (enalapril), or an angiotensin II receptor blocker (Losartan), or placebo. All patients had their usual Diabetes Mellitus (DM) management. Baseline studies included measures of glomerular filtration rate (GFR), urinary albumin excretion rate (UAE), blood pressure (BP), and a percutaneous renal biopsy. Patients were followed by quarterly measures of BP, HbA1C, UAE, and drug compliance. There were annual measures of GFR and a repeat renal biopsy after 5 yrs in the study. The main endpoint is kidney structural changes over time, especially mesangial fractional volume (v(Mes/glom)). Secondary endpoints will be other DN structural measures and measures of kidney function (UAE, GFR). These studies will determine whether rennin angiotensin system blockage in the early stages of DN can prevent the early kidney structural changes in this important disorder. Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants'''' compliance. Baseline, 2.5 and 5 year retinal fundus photographs in the RASS patients were obtained. | enalapril, drug, losartan, angiotensin, medication, kidney, intervention, clinical, adolescent, adult human, renal biopsy, renin-angiotensin system, diabetic nephropathy, kidney, placebo, glomerular filtration rate, urinary albumin excretion rate, blood pressure |
is related to: NIDDK Information Network (dkNET) has parent organization: ClinicalTrials.gov has parent organization: University of Minnesota Twin Cities; Minnesota; USA |
Type 1 diabetes, Diabetic kidney disease, Retinopathy, Nephropathy, Diabetes | NIDDK | PMID:19571282 | nlx_152849 | SCR_013385 | Renin Angiotensin System Blockage-DN (RASS), Renin Angiotensin System Study (RASS/B-RASS) | 2026-08-03 09:35:23 | 1 | |||||
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Cooperative Study Group for Autoimmune Disease Prevention Resource Report Resource Website |
Cooperative Study Group for Autoimmune Disease Prevention (RRID:SCR_006803) | CSGADP | resource, knowledge environment | Collaborative network of investigators with a focus on prevention of autoimmune disease, defined as halting the development of autoimmune disease prior to clinical onset by means other than global immunosuppression, and an emphasis on Type 1 diabetes. Its mission is to engage in scientific discovery that significantly advances knowledge for the prevention and regulation of autoimmune disease. The specific goals enunciated in pursuit of this mission are: * To create improved models of disease pathogenesis and therapy to better understand immune mechanisms that will provide opportunities for prevention strategies * To use these models as validation platforms with which to test new tools applicable to human studies * To encourage core expertise and collaborative projects designed for rapid translation from animal to human studies, emphasizing the development of surrogate markers for disease progression and/or regulation which can be utilized in the context of clinical trials | prevention, clinical, immune, model, disease pathogenesis, therapy |
is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources |
Type 1 diabetes, Diabetes, Autoimmune disease | NIAID ; NIDDK ; NICHD ; NIH Office of Research on Womens Health ; Juvenile Diabetes Research Foundation International |
nlx_152797 | SCR_006803 | 2026-08-03 09:33:15 | 0 | |||||||
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Type 1 Diabetes - Rapid Access to Intervention Development Resource Report Resource Website |
Type 1 Diabetes - Rapid Access to Intervention Development (RRID:SCR_000203) | T1D-RAID | resource, service resource | NOTE: The T1D-RAID program is not currently accepting applications. Cooperative program that makes available, on a competitive basis, NCI resources for the pre-clinical development of drugs, natural products, and biologics to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions for type 1 diabetes and its complications. A partial listing of those services includes: high-throughput screening, studies in animal models, formulation, pharmacology and toxicology studies, and bulk substances acquisition. Requests to T1D-RAID are brief (20 pages or less), and should clearly outline the resources required to ready the proposed therapeutic agent for clinical trials. T1D-RAID should enable entry into the clinic of promising molecules that are not otherwise likely to receive an adequate and timely clinical test. T1D-RAID is designed to accomplish the tasks that are rate-limiting in bringing discoveries from the laboratory to the clinic. Once a project has been approved, NIDDKstaff interact directly with the Principal Investigator (PI). NCI contractors perform the T1D-RAID-approved tasks under the direction of NIDDKand NCI staff. The required tasks will vary from project to project. In some cases T1D-RAID will support only one or two key missing steps necessary to bring a compound to the clinic; in other cases it may be necessary to supply the entire portfolio of development requirements needed to file an IND. Examples of tasks that can be supported by T1D-RAID include, but are not limited to: * Definition or optimization of dose and schedule for in vivo activity * Development of pharmacology assays * Conduct of pharmacology studies with a pre-determined assay * Acquisition of bulk substance (GMP and non-GMP) * Scale-up production from lab-scale to clinical-trials lot scale * Development of suitable formulations * Development of analytical methods for bulk substances * Production of dosage forms * Stability assurance of dosage forms * Range-finding initial toxicology * IND-directed toxicology, with correlative pharmacology and histopathology * Planning of clinical trials * Regulatory affairs, so that FDA requirements are likely to be satisfied by participating investigators seeking to test new molecular entities in the clinic * IND filing advice The output of T1D-RAID activities will be both products and information that will be made fully available to the originating investigator for support of an IND application and clinical trials. T1D-RAID does not sponsor clinical trials. | therapeutic, drug, drug development, pharmacogenomics |
is listed by: NIDDK Information Network (dkNET) is related to: Type 1 Diabetes Preclinical Testing Program has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Type 1 diabetes, Diabetes | NCI ; NIDDK |
nlx_152742 | SCR_000203 | Type 1 Diabetes - Rapid Access to Intervention Development (T1D-RAID) | 2026-08-03 09:30:59 | 0 | ||||||
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University of California San Francisco Diabetes Research Center Resource Report Resource Website |
University of California San Francisco Diabetes Research Center (RRID:SCR_015102) | resource, portal, topical portal, access service resource, disease-related portal, service resource, data or information resource | One of sixteen research centers established by the National Institute of Diabetes and Digestive and Kidney Diseases that fosters research and training in the areas of diabetes and related endocrine and metabolic disorders. | diabetes research, endocrine disorders, metabolic disorders |
is listed by: NIDDK Information Network (dkNET) is affiliated with: Diabetes Research Centers has parent organization: University of California at San Francisco; California; USA is parent organization of: University of California San Francisco Diabetes Research Center Mouse Genetics Core Facility is parent organization of: University of California San Francisco Diabetes Research Center Mouse Metabolism Core is parent organization of: University of California San Francisco Diabetes Research Center Microscopy Core Facility is parent organization of: University of California San Francisco Diabetes Research Center Lentiviral RNAi Core Facility is parent organization of: University of California San Francisco Parnassus Flow Cytometry Core Facility is parent organization of: University of California San Francisco Diabetes Research Center Islet Production Core Facility has organization facet: University of California San Francisco Diabetes Research Center Islet Production Core Facility has organization facet: University of California San Francisco Diabetes Research Center Mouse Metabolism Core has organization facet: University of California San Francisco Parnassus Flow Cytometry Core Facility has organization facet: University of California San Francisco Diabetes Research Center Microscopy Core Facility has organization facet: University of California San Francisco Diabetes Research Center Mouse Genetics Core Facility has organization facet: University of California San Francisco Diabetes Research Center Lentiviral RNAi Core Facility is organization facet of: Diabetes Research Centers |
Diabetes | NIDDK P30DK063720 | Available to the research community | SCR_015102 | 2026-08-04 09:43:36 | 0 | ||||||||
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Michigan Center for Diabetes Translational Research Resource Report Resource Website 1+ mentions |
Michigan Center for Diabetes Translational Research (RRID:SCR_015187) | MCDTR | topical portal, portal, disease-related portal, data or information resource | Multidisciplinary unit of the University of Michigan funded by National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health. MCDTR is one of seven NIH Centers funded to focus on type 2 translational research in diabetes with mission to establish, promote, and enhance multidisciplinary collaboration among researchers directed at prevention and control of diabetes, its complications, and comorbidities, by providing access to specialized expertise and resources. | translational diabetes research, multidisciplinary collabroation, clinical research, implementation research |
is affiliated with: Centers for Diabetes Translation Research has parent organization: University of Michigan Medical School; Michigan; USA is parent organization of: Michigan Center for Diabetes Translational Research Administrative Core Facility is parent organization of: Michigan Center for Diabetes Translational Research Methods and Measurements Core is parent organization of: Michigan Center for Diabetes Translational Research Intervention and Technology Research Core is parent organization of: Michigan Center for Diabetes Translational Research Leveraging Community, Peer, and Family Support Core Facility has organization facet: Michigan Center for Diabetes Translational Research Administrative Core Facility has organization facet: Michigan Center for Diabetes Translational Research Methods and Measurements Core has organization facet: Michigan Center for Diabetes Translational Research Intervention and Technology Research Core has organization facet: Michigan Center for Diabetes Translational Research Leveraging Community, Peer, and Family Support Core Facility is organization facet of: Centers for Diabetes Translation Research |
Diabetes | NIDDK P30DK092926 | http://diabetesresearch.med.umich.edu | SCR_015187 | 2026-08-04 09:43:37 | 1 | |||||||
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Center for Iron and Heme Disorders at the University of Utah Resource Report Resource Website |
Center for Iron and Heme Disorders at the University of Utah (RRID:SCR_015341) | resource, portal, topical portal, access service resource, disease-related portal, service resource, data or information resource | Research center for iron and hematology research. It hosts cores that provide services for mutation generation and detection, metabolomics, and iron and heme experiments and research. In addition to these cores, it has an Enrichment Program, and Internal and External Advisory Committees, and a Pilot and Feasibility program. | iron and hematology research, mutation generation, metabolomics, enrichment progarm. |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Utah School of Medicine; Utah; USA is parent organization of: Center for Iron and Heme Disorders at the University of Utah Administrative Core is parent organization of: Center for Iron and Heme Disorders at the University of Utah Iron and Heme Core is parent organization of: Center for Iron and Heme Disorders at the University of Utah Metabolomics Core is parent organization of: Center for Iron and Heme Disorders at the University of Utah Mutation Generation and Detection Core has organization facet: Center for Iron and Heme Disorders at the University of Utah Iron and Heme Core has organization facet: Center for Iron and Heme Disorders at the University of Utah Mutation Generation and Detection Core has organization facet: Center for Iron and Heme Disorders at the University of Utah Metabolomics Core has organization facet: Center for Iron and Heme Disorders at the University of Utah Administrative Core is organization facet of: Hematology Centers |
iron disorder, heme disorder | NIDDK U54DK110858 | Available to the research community | SCR_015341 | 2026-08-04 09:43:38 | 0 | ||||||||
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University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Resource Report Resource Website |
University of North Carolina at Chapel Hill Nutrition and Obesity Research Center (RRID:SCR_015462) | resource, portal, topical portal, access service resource, disease-related portal, service resource, data or information resource | Center whose goals include providing resources and support to investigators conducting multidisciplinary and interdisciplinary research in nutritional sciences and obesity, strengthening clinical nutrition training programs for medical students, practicing physicians, and allied health personnel, and translating findings from obesity and nutrition research to the general public. | obesity research center, nutritional sciences, obesity research |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Research Facilitation Program is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Biostatistics Program is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Animal Metabolism Phenotyping Core is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Metabolic Molecular Phenotyping Core is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Communication for Health Applications and Interventions Core is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Clinical Nutrition Research Facilitation Program is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Administrative Core is parent organization of: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Diet and Physical Activity Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Administrative Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Diet and Physical Activity Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Metabolic Molecular Phenotyping Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Communication for Health Applications and Interventions Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Animal Metabolism Phenotyping Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Nutrigenetics Core has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Biostatistics Program has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Clinical Nutrition Research Facilitation Program has organization facet: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Research Facilitation Program is organization facet of: Nutrition and Obesity Research Centers |
Obesity | NIDDK DK056350 | Available to the research community | SCR_015462 | 2026-08-04 09:43:39 | 0 |
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