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http://www.t1diabetes.nih.gov/t1d-raid/index.shtml
NOTE: The T1D-RAID program is not currently accepting applications. Cooperative program that makes available, on a competitive basis, NCI resources for the pre-clinical development of drugs, natural products, and biologics to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions for type 1 diabetes and its complications. A partial listing of those services includes: high-throughput screening, studies in animal models, formulation, pharmacology and toxicology studies, and bulk substances acquisition. Requests to T1D-RAID are brief (20 pages or less), and should clearly outline the resources required to ready the proposed therapeutic agent for clinical trials. T1D-RAID should enable entry into the clinic of promising molecules that are not otherwise likely to receive an adequate and timely clinical test. T1D-RAID is designed to accomplish the tasks that are rate-limiting in bringing discoveries from the laboratory to the clinic. Once a project has been approved, NIDDKstaff interact directly with the Principal Investigator (PI). NCI contractors perform the T1D-RAID-approved tasks under the direction of NIDDKand NCI staff. The required tasks will vary from project to project. In some cases T1D-RAID will support only one or two key missing steps necessary to bring a compound to the clinic; in other cases it may be necessary to supply the entire portfolio of development requirements needed to file an IND. Examples of tasks that can be supported by T1D-RAID include, but are not limited to: * Definition or optimization of dose and schedule for in vivo activity * Development of pharmacology assays * Conduct of pharmacology studies with a pre-determined assay * Acquisition of bulk substance (GMP and non-GMP) * Scale-up production from lab-scale to clinical-trials lot scale * Development of suitable formulations * Development of analytical methods for bulk substances * Production of dosage forms * Stability assurance of dosage forms * Range-finding initial toxicology * IND-directed toxicology, with correlative pharmacology and histopathology * Planning of clinical trials * Regulatory affairs, so that FDA requirements are likely to be satisfied by participating investigators seeking to test new molecular entities in the clinic * IND filing advice The output of T1D-RAID activities will be both products and information that will be made fully available to the originating investigator for support of an IND application and clinical trials. T1D-RAID does not sponsor clinical trials.
Proper citation: Type 1 Diabetes - Rapid Access to Intervention Development (RRID:SCR_000203) Copy
https://diabetescenters.org/centers
Diabetes Research Centers (DRC) is an integrated program of diabetes, endocrinology and metabolism research.
Proper citation: Diabetes Research Centers (RRID:SCR_014535) Copy
http://chromus.vet.cornell.edu/why-chromus/
A transgenic mouse supplier which develops mouse lines expressing genetically encoded calcium indicators (GECIs) and optogenetic effectors in lineages relevant to cardiac, vascular, lung and blood diseases. The mouse strains created are designed to allow for inter crossing resulting in co-expression of sensors with discrete emission wavelengths in interacting lineages (e.g. endothelial and smooth muscle cells), as well as optically compatible effector/detector pairs.
Proper citation: Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (CHROMus) (RRID:SCR_014522) Copy
Institution which compiles and distributes small molecule crystallography data from the Cambridge Structural Database (CSD), a repository of experimentally determined organic and metal-organic crystal structures. CCDC also produces associated knowledge-based application software for structural chemists. Structures deposited with CCDC are made publically available for download at the point of publication or at consent from the depositor.
Proper citation: Cambridge Crystallographic Data Centre (CCDC) (RRID:SCR_014707) Copy
One of sixteen research centers established by the National Institute of Diabetes and Digestive and Kidney Diseases that fosters research and training in the areas of diabetes and related endocrine and metabolic disorders.
Proper citation: University of California San Francisco Diabetes Research Center (RRID:SCR_015102) Copy
Research center for iron and hematology research. It hosts cores that provide services for mutation generation and detection, metabolomics, and iron and heme experiments and research. In addition to these cores, it has an Enrichment Program, and Internal and External Advisory Committees, and a Pilot and Feasibility program.
Proper citation: Center for Iron and Heme Disorders at the University of Utah (RRID:SCR_015341) Copy
http://sph.unc.edu/norc/norc-home/
Center whose goals include providing resources and support to investigators conducting multidisciplinary and interdisciplinary research in nutritional sciences and obesity, strengthening clinical nutrition training programs for medical students, practicing physicians, and allied health personnel, and translating findings from obesity and nutrition research to the general public.
Proper citation: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center (RRID:SCR_015462) Copy
https://ww2.mc.vanderbilt.edu/ddrc/
Center whose objectives include promoting digestive diseases-related research in an integrative, collaborative and multidisciplinary manner, developing and implementing programs for attracting, training, and retaining young investigators in digestive disease-related research, and facilitating the transfer of basic research discoveries to improvements in prevention and/or clinical care.
Proper citation: Vanderbilt Digestive Disease Research Center (RRID:SCR_015225) Copy
http://depts.washington.edu/uwnorc/
Research center that facilitates the integration and coordination of the ongoing activities of the University of Washington system. Its overarching goals are to foster interdisciplinary research collaborations, stimulate new research activities, improve nutrition and obesity education, and facilitate optimal nutritional management of patients.
Proper citation: University of Washington Nutrition and Obesity Research Center (RRID:SCR_015475) Copy
http://www.urology.wisc.edu/research/u54-george-m-obrien-center-for-benign-urology-research
Research center that is dedicated to improving urologic health in aging men by promoting development of urologic research, disseminating urologic research knowledge, and performing other research-related tasks.
Proper citation: O'Brien Center for Benign Urologic Research at University of Wisconsin-Madision and University of Massachusetts-Boston (RRID:SCR_015476) Copy
https://www.niddk.nih.gov/research-funding/research-programs/urologic-disease-centers
Program that aims to enhance the effectiveness of research related to noncancerous urologic dysfunction by encouraging collaboration amongst investigators.
Proper citation: O'Brien Urology Centers (RRID:SCR_015473) Copy
Center which promotes multidisciplinary research in diabetes through raising awareness and interest in fundamental and clinical research, enhancing diabetes research, education and training opportunities, and providing core services that leverage funding and unique expertise.
Proper citation: University of Chicago Diabetes Research and Training Center (RRID:SCR_015114) Copy
https://www.bcm.edu/research/centers/digestive-disease
Center designed to serve basic and clinical scientists at institutions within the Texas Medical Center, including Baylor College of Medicine, The University of Texas Health Science Center at Houston and the MD Anderson Cancer Center. It facilitates digestive diseases research, promotes translational collaborative research between basic and clinical areas, develops new projects, nurtures new investigators, and provides GI educational activities.
Proper citation: Texas Medical Center Digestive Diseases Center (RRID:SCR_015191) Copy
https://www.cincinnatichildrens.org/research/divisions/d/dhc
Center that is located within Cincinnati Children's Hospital Medical Center, that serves as a University of Cincinnati Academic Health Center resource to foster pediatric digestive disease research and make discoveries to restore digestive health.
Proper citation: Cincinnati Digestive Health Center (RRID:SCR_015196) Copy
http://medicine.yale.edu/labmed/ycceh/
Research center that provides access to and training in hematology technologies via three technology cores, Pilot and Feasibility funding, and an Enrichment Program.
Proper citation: Yale Cooperative Center of Excellence in Hematology (RRID:SCR_015351) Copy
https://gns.wustl.edu/research/nutrition-obesity-research-center/
Research center whose activities aim to enhance understanding of the basic and clinical aspects of nutrition in the prevention, etiology, pathophysiology and therapy of nutrition-related diseases.
Proper citation: Washington University St. Louis Nutrition Obesity Research Center (RRID:SCR_015472) Copy
https://nyonrc.cumc.columbia.edu
Obesity research center which provides access to core facilities, seminars, and collaborations for researchers.
Proper citation: New York Obesity Nutrition Research Center (RRID:SCR_015442) Copy
http://www.kidneycenter.pitt.edu/
Center whose focus is to advance knowledge of normal kidney function, cellular mechanisms that contribute to kidney disease, and the myriad altered cellular functions that occur in the setting of renal insufficiency.
Proper citation: Pittsburgh Center for Kidney Research (RRID:SCR_015286) Copy
Research center whose goal is to define the underlying mechanisms of disease and to contribute to the prevention and treatment of obesity and its complications. It provides collective research facilities, a lecture program that fosters interactions amongst laboratories conducting cellular, animal, translational, clinical and epidemiologic research, pilot funding for new and interdisciplinary research directions plus administrative infrastructure that promotes these integrative goals.
Proper citation: University of California San Francisco Nutrition and Obesity Research Center (RRID:SCR_015446) Copy
http://www.massgeneral.org/csibd/
Multidisciplinary program which aims to define fundamental mechanisms underlying Crohn?s disease and ulcerative colitis. It actively promotes clinical and translational research efforts to apply insights gained in studying various disease mechanisms through its five biomedical cores: the Human Genetics and Microbiome Core, the Morphology Core, the Immunology Core, the Genetic Animal Models Core and the Clinical Core.
Proper citation: Center for the Study of Inflammatory Bowel Disease (RRID:SCR_015202) Copy
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