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http://mimas.ac.uk/

Mimas is an organization of experts. Our role is to support the advancement of knowledge, powering world-class research and teaching. Technology is at the heart of everything we do. As a nationally designated data center, we host a significant number of the UK''s research information assets. But our core expertise is building applications that enable a wide range of users to make the most of this rich resource from students and researchers working with census data to investigate social inequalities, to scientists using satellite imagery to survey and protect our environment. We have a longstanding relationship with JISC, developing services that support teaching, learning and research and strong connections with research councils, especially the Economic and Social Research Council (ESRC). We also have partnerships with commercial groups, universities and colleges, government agencies, and national libraries and archives. * An organization of experts: We''re experts in technological development, information management, user support, training, project management, and applied research. * What we do: We maintain and support quality services, develop applications and software, provide data hosting and storage, and share our learning. * What we stand for: Four main principles guide our activities: commitment to our users, technological experimentation and innovation, communication within our community, and investment in staff.

Proper citation: Mimas (RRID:SCR_006529) Copy   

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http://ecvam.jrc.it/

ECVAM was created by a Communication from the Commission to the Council and the Parliament in October 1991*, pointing to a requirement in Directive 86/609/EEC** on the protection of animals used for experimental and other scientific purposes, which requires that the Commission and the Member States should actively support the development, validation and acceptance of methods which could reduce, refine or replace the use of laboratory animals: Article 7.2: An experiment shall not be performed if another scientifically satisfactory method of obtaining the result sought, not entailing the use of an animal, is reasonably and practicably available. Article 23: The Commission and Member States should encourage research into the development and validation of alternative techniques which could provide the same level of information as that obtained in experiments using animals, but which involve fewer animals or which entail less painful procedures, and shall take such other steps as they consider appropriate to encourage research in this field. ECVAM has been established in 1992 as a unit of the Environment Institute, part of the Joint Research Centre, and has been transferred to, at that time, newly formed Institute for Health and Consumer Protection in Ispra, Italy in 1998 of which ECVAM is still part of. Duties of ECVAM As defined in the Communication of the European Commission to Council and the European Parliament in October 1991*: 1. To coordinate the validation of alternative test methods at the European Union level. 2. To act as a focal point for the exchange of information on the development of alternative test methods. 3. To set up, maintain and manage a data base on alternative procedures. 4. To promote dialogue between legislators, industries, biomedical scientists, consumer organisations and animal welfare groups, with a view to the development, validation and international recognition of alternative test methods. Moreover, ECVAM should help to expand the JRC''s role in prenormative research. ECVAM thus seeks to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, through research, new test development and validation, and the establishment of specialised databases, with the aim of contributing to the replacement, reduction and refinement of laboratory animal precedures (in accordance with the 3Rs concept of Russell & Burch***) Due to the political sensitivity of its duties, ECVAM, uniquely at the JRC, has its own Scientific Advisory Committee (ESAC) with participation from all Member States, relevant industrial associations, academic toxicology, the animal welfare movement, as well as other Commission services with interest in the alternatives topic area. The Validation Process Validation is the process by which the reliability and relevance of a procedure are established for a specific purpose. In 1995, based upon experience gained during several recent large-scale validation studies, and in consultation with various international experts (including members of ERGATT), ECVAM published recommendations concerning the practical and logistical aspects of validating alternative test methods (ECVAM workshop report 5). Five main stages in the evolution of new test methods were identified: test development; prevalidation; validation (involving a formal interlaboratory study with the testing of coded chemicals); independent assessment; and progression toward regulatory acceptance. ECVAM has implemented a prevalidation scheme, which includes three main phases: protocol refinement, protocol transfer, and protocol performance. The objective of the prevalidation process is to ensure that any method included in a formal validation study adequately fulfills the criteria defined for inclusion in such a study, so that financial and human resources are used more efficiently, and so that there is a greater likelihood that the expectations of those in the scientific, regulatory and animal welfare communities, who seek the replacement of current animal tests by relevant and reliable alternative methods, will be met. In 2004, ECVAM has published the Modular Approach to the ECVAM Principles on Test Validity (select from the top-menu bar the sector Publications followed by ECVAM Selected Articles) that makes the validation process more flexible, by breaking down the various steps in validation into indipendent modules, and defining for each module the information needed for assessing test validity. Collaborations ECVAMs activities are undertaken in collaboration with numerous laboratories and organisations in the EU Member States, and all over the world. ECVAM also works in close collaboration with other Commission services, such as DG Environment, DG Enterprise, DG Research and DG Health and Consumer Protection. Sponsor. This is a Five years project funded by DG RTD that aims to develop a testing strategy to improve the prediction of oral acute toxicity using non-animals based systems.

Proper citation: European Centre for the Validation of Alternative Methods (RRID:SCR_008504) Copy   

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http://eurobonet.pathobiology.eu/cd/

Integration objectives Training and education Standardisation in technology Share of material Web based sharing of information and communication Translational research Spreading excellence objectives Coordinated by Treviso Courses on bone pathology and molecular biology Standard Operation Protocols Web-based discussion forums Research objectives Work packages on: Cartilaginous Tumours (Leiden) Osteogenic Tumours (Munster) Giant Cell Tumours (Oxford) Ewing Sarcoma (Bologna)

Proper citation: Eurobonet (RRID:SCR_008503) Copy   

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http://www.nitrc.org/projects/autoseg/

A novel C++ based application developped at UNC-Chapel Hill that performs automatic brain tissue classification and structural segmentation. AutoSeg is designed for use with human and non-human primate pediatric, adolescent and adult data. AutoSeg uses a BatchMake pipeline script that includes the main steps of the framework entailing N4 bias field correction, rigid registration to a common coordinate image, tissue segmentation, skull-stripping, intensity rescaling, atlas-based registration, subcortical segmentation and lobar parcellation, regional cortical thickness and intensity statistics. AutoSeg allows efficient batch processing and grid computing to process large datasets and provides quality control visualizations via Slicer3 MRML scenes.

Proper citation: AutoSeg (RRID:SCR_009438) Copy   

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http://www.nitrc.org/projects/bxh_xcede_tools/

A collection of data processing and image analysis tools for data in BXH or XCEDE format. This includes data format encapsulation/conversion, event-related analysis, QA tools, and more. These tools form the basis of the fBIRN QA procedures and are also distributed as part of the fBIRN Data Upload Scripts.

Proper citation: BXH/XCEDE Tools (RRID:SCR_009439) Copy   

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http://www.cytopathology-foundation.org/

Cytopathology Foundation is a non-profit organization dedicated to the health care for the advancement of art and science of Cytopathology dealing with study of cells for proper disease management especially cancer. Cytopathology is a well established diagnostic sub-specialty of pathology. Instead of using surgically removed tissue to arrive at a diagnosis it attempts to identify diagnostic and prognostic information from dispersed cells obtained by non-invasive or minimally invasive techniques. An example, and its greatest success story thus far, is the role it has played in the battle with cervical cancer. The introduction of the Pap smear has contributed immensely to the early diagnosis and significantly decreased mortality of cervical cancer. Activities of the foundation 1. Support the mission statement in general. 2. Support the editorial and publication expenses of CytoJournal. 3. Future activities may include publication and marketing of cytopathology related literature, to generate funds. 4. Support any other scholarly activities in Cytopathology and related areas.

Proper citation: Cytopathology Foundation (RRID:SCR_008467) Copy   

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http://dsi-studio.labsolver.org

A software for diffusion MR images analysis. The provided functions include reconstruction (DTI, QBI, DSI, and GQI), deterministic fiber tracking, and 3D visualization. It has a window-based interface and operates on Microsoft Windows system.

Proper citation: DSI Studio (RRID:SCR_009557) Copy   

•   Source: SciCrunch Registry

http://nimhstemcells.org/

Induced Pluripotent Stem Cell (iPSC) and Source Cells available for distribution for postnatal-to-adult human control and patient-derived cells and their reprogrammed derivatives in support of stem cell research relevant to mental disorders. This includes but is not limited to anxiety disorders, attention deficit hyperactivity disorder, autism spectrum disorders, bipolar disorder, borderline personality disorder, depression, eating disorders, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and schizophrenia. The capabilities of the repository range from derivation and banking of primary source cells from postnatal through adult human subject tissue to more comprehensive banking and validation of induced pluripotent stem cells (iPSCs) or similar reprogrammed / de-differentiated cells. Please send a message with the Contact page if you wish to contribute source cells or iPSC.

Proper citation: NIMH Stem Cell Center (RRID:SCR_006682) Copy   

•   Source: SciCrunch Registry

https://data.aad.gov.au/

Centre is committed to free and open exchange of scientific data and is working collaboratively with international centres, networks and scientists to build sustainable polar data commons. Delivers professional data management and analysis services to Antarctic scientists and environmental managers. Supports logistical operations of Australian Antarctic Program. Data held in AADC data stores are qualified with metadata and discoverable through Catalogue of Australian Antarctic and Sub-antarctic Metadata (CAASM http://data.aad.gov.au/aadc/metadata) or through customized applications accessible via the website. All data is archived in AADC to permit its re-use. AADC has capability to create DOIs for datasets.

Proper citation: Australian Antarctic Data Centre (RRID:SCR_006320) Copy   

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http://tronolab.epfl.ch

Retroelements constitute important evolutionary forces for the genome of higher organisms, yet their uncontrolled spread, whether from endogenous loci or within the context of viral infections, can cause diseases such as cancer, hepatitis and AIDS. Correspondingly, a variety of host-encoded activities limit this process, belonging to a line of defense commonly called intrinsic or innate immunity, which notably contributes to taming endogenous retroelements and to restricting the cross-species transmission of retroviruses. Our work aims at characterizing the relationship between retroelements and their hosts, which has recently led us to become more generally interested in epigenetic mechanisms regulating the expression of mammalian genomes.

Proper citation: Tronolab (RRID:SCR_008580) Copy   

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http://bnmc.caltech.edu/

The Beckman Institute BNMC brings together researchers from many disciplines at Caltech to address problems in the mechanistic modeling of coupled genomic, intercellular and intracellular processes. It represents an attempt to encourage closer interaction and collaboration between groups in Biology, Control and Dynamical Systems, and the Center for Advanced Computing Research. The focus of BNMC is biochemical phenomena occurring within and between cells, in particular the mechanistic modeling of molecular networks of all kinds (e.g., transcriptional, regulatory, metabolic, signal transduction, mechanical, etc.) with and without spatial variation and intercellular communication. BNMC is formed as a coordinated effort aimed at (1) applying existing capabilities to collaboratively solve biological modeling problems that arise in answering scientific questions in Caltech laboratories, (2) exploring a diversity of novel approaches in order to achieve fundamental advances necessary to address the classes of modeling problems biologists want to solve, and (3) organizing projects to better share human experience as well as common infrastructure to avoid duplication and maximize solution interoperability.

Proper citation: Caltech, The Beckman Institute: The Biological Network Modeling Center (RRID:SCR_008060) Copy   

•   Source: SciCrunch Registry

http://1mind4research.org/

One Mind for Research''s plan to work smarter and share resources through public and private partnerships has the power to help us make more progress on every brain disorder from schizophrenia to traumatic brain injury. In the process, we will increase the investment in research by $1.5 billion each year for the next 10 years. And achieve a minimum 10% reduction in the cost of brain disease per year. This is how neurological cures that once seemed beyond our reach begin to take shape. When we''re all of one mind working toward the same goal, anything can be accomplished. $8 billion a year is spent on brain research, but the minimum cost of brain disease is one hundred times that. Yet amazingly, unlocking the mysteries of the human brain has less to do with resources than it does their coordination. Because though there is science, it exists in many different silos. There has never been a single organization that brings together the science, technology, financial resources and knowledge required to create an unprecedented understanding of brain disease. Until now. The One Mind for Research Forum began on May 23, 2011 and over the course of 2 days, the best and brightest from around the world gathered as part of a national collaboration of research universities, scientists, and the National Institutes of Health (NIH) Directors as they imagined an ambitious 10-year plan for neuroscience research. One Mind believes that new treatments and cures for neurological and psychiatric diseases that afflict one in three Americans, from children with autism to senior citizens with Alzheimer''s disease, are all within reach.

Proper citation: One Mind for Research (RRID:SCR_006711) Copy   

•   Source: SciCrunch Registry

http://www.sabc.murdoch.edu.au/

The SABC is the collaborative university Centre for R&D in agricultural and veterinary biotechnology in Western Australia. It provides platform technologies and world class equipment and facilities for R&D in agricultural biotechnology to researchers from universities, state government and industry. More than 20 research groups and companies rent space and use the SABC facilities. It is based at Murdoch University in Perth. Our Vision To be an eminent, internationally recognized centre for research and development in agriculture and veterinary biotechnology Our Mission To provide state-of-the-art facilities and equipment enabling multi disciplinary research in biotechnology which under pins the agricultural and veterinary industry, for the benefit of the community. This will be achieved by being recognised as the centre for agricultural biotechnology in WA providing national and international research links and collaborations fostering establishment of national centres in leading edge technologies Characteristics of the SABC * The SABC is a multi-user centre with a research spend of about $9 million pa * There is a critical mass of more than 225 researchers * The SABC combines university, state government and industry researchers in one cost-effective centre * The SABC operates as a ''Research Hotel'' in which different groups rent common laboratory space and access to platform technologies * The SABC supports incubation and co-location of new ag biotech companies in WA * The SABC promotes collaborative research, undertakes contract research, and provides many local, national and international linkages * SABC researchers are members of eight agricultural Cooperative Centres (CRCs) Research Focus The research focus is on molecular activities that involve or promote primary production of commercial livestock, crop plants or microbes, or their subsequent processing for added value. The SABC also supports research in biomedical sciences, and environmental biotechnology. Deliverables and Outcomes SABC researchers have an outstanding track record of outputs and outcomes. These include the provision of co-located, state-of-the art, well run platform technologies for all WA researchers plant breeding support leading to improved crop varieties (molecular markers, yield, resistance to diseases and pests, better quality, variety ID, diagnostics), improved productivity and health of livestock, and biomedical diagnostics. Facilities and platform technologies The SABC provides the most comprehensive set of equipment and facilities for biotechnology R&D in WA, with full facilities for: cell and molecular biology, robotics, high throughput agricultural genetic analyses and diagnostics, structural, comparative and functional genomics, microarray technologies, proteomics and mass spectroscopy and bioinformatics support via the (CBBC). Training and Mentoring The SABC plays a major role in advanced training in ag biotech. There are about 100 Honours and PhD students in the research complement. The SABC also runs a series of hands on short courses in molecular biology, gene mapping, diagnostics, proteomics and bioinformatics. In 2005 new postgraduate certificate and diploma courses on Application of Molecular Technologies was established at Murdoch University, run by internationally qualified SABC researchers. These provide advanced education at the Postgraduate Certificate, Diploma and MSc levels, for local and international participants. click here for details The SABC runs the following hands-on training workshops: * Introduction to Molecular Biology * Molecular Mapping Techniques in Diagnostic Biotechnology * High Throughput Genetic Analysis * Introduction to Proteomics * Advanced Proteomics * Bioinformatics (with the CBBC) Competitive Advantages The SABC: * combines crop, veterinary and biomedical research in biotechnology in one centre * is multidisciplinary and inclusive * provides enabling facilities, platform technologies and common laboratories * is highly cost effective Researcher Groups Using the SABC * Division of Health Sciences (Murdoch)/Veterinary Sciences * Division of Science and Engineering (Murdoch)/Biological Sciences and Biotechnology * UWA (Natural Resources and Agriculture, Biochemistry) * Curtin University (Molecular Biotechnology, Horticulture) * Edith Cowan University (Human Genetics) * WA Dept of Agriculture (animal, plant, microbial) * Fisheries * Perth Zoo * Plant Biotechnology Research Group * Australian Centre for Necrotrophic Fungal Pathogens (ACNFP) * Rumen Biotechnology * Centre for High Throughput Agricultural Genetic Analysis (CHAGA) * Veterinary Virology, Parasitology, Microbiology * Saturn Biotech Pty Ltd * Grain Biotech Australia Pty Ltd * Proteomics International * Lighthouse Laboratories Pty Ltd * ID PLUS Pty Ltd * Royal Perth Hospital * Fremantle Hospital * Australian Neuromuscular Research Institute (ANRI) Partnering Opportunities The SABC can provide full facilities for contract R&D, start up companies or co-location of existing companies in agricultural, veterinary and biomedical sciences via its incubation program. Contact the Director for further information. Partnering Needs Investors interested in commercializing outputs of SABC researchers.

Proper citation: Western Australian State Agricultural Biotechnology Centre (RRID:SCR_008577) Copy   

•   Source: SciCrunch Registry

http://www.mrli.ppdi.com

PPD is a leading global contract research organization (CRO), celebrating 25 years of providing drug discovery, development and lifecycle management services. Our clients and partners include pharmaceutical, biotechnology, medical device, academic and government organizations. With offices in 41 countries and more than 10,500 professionals worldwide, PPD applies innovative technologies, therapeutic expertise and a commitment to quality to help clients and partners accelerate the delivery of safe and effective therapeutics and maximize the returns on their R&D investments. Discovery Services: BioDuro, A PPD Company A drug discovery services company focused on integrated drug discovery programs Nonclinical development Preclinical services partners. Compound Partnering PPD''s compound partnering business is now Furiex Pharmaceuticals, Inc., an independent, publicly traded company. Collaboration with Merck Our strategic collaboration with Merck enabled us to acquire its vaccines and biologics infrastructure, broaden our therapeutic expertise and expand our existing relationship. Alliance with WHISCON We have expanded our post-approval safety expertise and risk management through an alliance with World Health Information Science Consultants. Partnership with PUL To meet growing client demand in Southeast Asia, we partnered with Peking Union Lawke Biomedical Development Limited (PUL) to establish our central lab services in China. Our e-Newsletter is your source for what is happening at PPD and in the CRO industry.

Proper citation: Clinical Trial Solutions with PPD (RRID:SCR_008457) Copy   

•   Source: SciCrunch Registry

https://corporate.qiagen.com/newsroom/press-releases/press-release-details/2009/QIAGEN-to-Acquire-SABiosciences/default.aspx

SABiosciences, as part of QIAGEN, offers nucleic acid (DNA, RNA, miRNA) and protein isolation, preparation and purification services, as well as assay,array, sequencing, NGS and biomarker services and lab essentials.Offers PCR services, assays, array systems, and expression vectors. Acquired by QIAGEN in 2009.

Proper citation: SABiosciences (RRID:SCR_008578) Copy   

•   Source: SciCrunch Registry

http://www.rickhanseninstitute.org

Organization that facilitates spinal cord injury research and care. By accelerating the translation of discoveries and best practices into improved treatments, it aims to improve the lives of people living with SCI.

Proper citation: Rick Hansen Institute (RRID:SCR_008570) Copy   

•   Source: SciCrunch Registry

http://www.nitrc.org/projects/namicdtifiber/

Project hosting binary packaged distributions, scripts, example datasets, and corresponding results of analysis using their UNC/Utah NAMIC DTI Fiber Analysis Framework. This project can be seens as a master project encompassing several current NITRC projects into a coherent set. Their workflow utilizes tools already available on NITRC including: * DTIPrep * DTIAtlasBuilder * FiberViewerLight * DTIAtlasFiberAnalyzer * FADTTS

Proper citation: UNC/Utah NAMIC DTI Fiber Analysis Framework (RRID:SCR_009615) Copy   

•   Source: SciCrunch Registry

http://www.nhpreagents.org

Center that facilitates the optimal use of nonhuman primate models in biomedical research by identifying, developing, characterizing and producing reagents for monitoring or modulating immune responses. They distribute non-human primate-specific antibodies for in vitro diagnostics, as well as develop and produce primate recombinant antibodies for in vivo cell depletion or modulating immune responses.

Proper citation: Nonhuman Primate Reagent Resource (RRID:SCR_012986) Copy   

•   Source: SciCrunch Registry

http://www.mitre.org/

The MITRE Corporation is a not-for-profit organization chartered to work in the public interest. As a national resource, we apply our expertise in systems engineering, information technology, operational concepts, and enterprise modernization to address our sponsors'' critical needs. MITRE manages Federally Funded Research and Development Centers (FFRDCs): one for the Department of Defense (known as the DoD Command, Control, Communications and Intelligence FFRDC), one for the Federal Aviation Administration (the Center for Advanced Aviation System Development), one for the Internal Revenue Service and U.S. Department of Veterans Affairs (the Center for Enterprise Modernization), and one for the Department of Homeland Security (the Homeland Security Systems Engineering and Development Institute). We believe that each FFRDC benefits from being part of an independent, not-for-profit company managing multiple FFRDCs. MITRE also has its own independent research and development program that explores new technologies and new uses of technologies to solve our sponsors'' problems in the near-term and in the future. MITRE has 7,000 scientists, engineers and support specialists65 percent of whom have Masters or Ph.D. degrees. Staff members work on hundreds of different projects across the company, demanding a high level of technical, operational, and domain knowledge. The MITRE Corporation has two principal locations: Bedford, Massachusetts, and McLean, Virginia. MITRE also has additional sites across the country and around the world.

Proper citation: MITRE (RRID:SCR_010690) Copy   

•   Source: SciCrunch Registry

http://www.tcgls.com/

Leading contract research and manufacturing services company in the area of drug discovery and development.

Proper citation: TCG Life Sciences (RRID:SCR_010571) Copy   

•   Source: SciCrunch Registry