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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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Human Genome Variation Society: Databases and Other Tools Resource Report Resource Website 10+ mentions |
Human Genome Variation Society: Databases and Other Tools (RRID:SCR_006876) | HGVS Databases & Other Tools | data or information resource, data set | A list of various databases freely available to the public, including several mutation and variation resources, such as education resources for teachers students provided by the Human Genome Variation Society. Databases listed include: * Locus Specific Mutation Databases * Disease Centered Central Mutation Databases * Central Mutation and SNP Databases * National and Ethnic Mutation Databases * Mitochondrial Mutation Databases * Chromosomal Variation Databases * Other Mutation Databases ( i.e. your round holes don''''t fit our square pegs) * Clinical and Patient Aspects Databases * Non Human Mutation Databases * Artificial Mutations Only * Other Related Databases * Education Resources for Teachers and Students | genome, artificial, chromosome, clinical, disease, human, mitochondrial, non human, snp, mutation, genetic variation, education, ethnic | has parent organization: Human Genome Variation Society | Public | nif-0000-02959 | SCR_006876 | HGVS: Databases and Other Tools | 2026-09-19 12:58:39 | 15 | |||||||
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UniProt Chordata protein annotation program Resource Report Resource Website |
UniProt Chordata protein annotation program (RRID:SCR_007071) | Chordata protein annotation program | data or information resource, data set | Data set of manually annotated chordata-specific proteins as well as those that are widely conserved. The program keeps existing human entries up-to-date and broadens the manual annotation to other vertebrate species, especially model organisms, including great apes, cow, mouse, rat, chicken, zebrafish, as well as Xenopus laevis and Xenopus tropicalis. A draft of the complete human proteome is available in UniProtKB/Swiss-Prot and one of the current priorities of the Chordata protein annotation program is to improve the quality of human sequences provided. To this aim, they are updating sequences which show discrepancies with those predicted from the genome sequence. Dubious isoforms, sequences based on experimental artifacts and protein products derived from erroneous gene model predictions are also revisited. This work is in part done in collaboration with the Hinxton Sequence Forum (HSF), which allows active exchange between UniProt, HAVANA, Ensembl and HGNC groups, as well as with RefSeq database. UniProt is a member of the Consensus CDS project and thye are in the process of reviewing their records to support convergence towards a standard set of protein annotation. They also continuously update human entries with functional annotation, including novel structural, post-translational modification, interaction and enzymatic activity data. In order to identify candidates for re-annotation, they use, among others, information extraction tools such as the STRING database. In addition, they regularly add new sequence variants and maintain disease information. Indeed, this annotation program includes the Variation Annotation Program, the goal of which is to annotate all known human genetic diseases and disease-linked protein variants, as well as neutral polymorphisms. | chordata, protein, protein annotation, functional annotation, human, non-human vertebrate, xenopus laevis, xenopus tropicalis, zebrafish, protein sequence, protein sequencing, nucleotide sequence, sequence, annotation, sequence variant, disease, proteome, gold standard |
is related to: Human Proteomics Initiative is related to: UniProtKB has parent organization: UniProt |
nlx_143879 | SCR_007071 | 2026-09-19 12:58:39 | 0 | |||||||||
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DeepBehavior Resource Report Resource Website |
DeepBehavior (RRID:SCR_021414) | data analysis software, data processing software, software application, software resource, software toolkit | Software toolbox that automates taking high speed quality video to track behavior to analyze and track behavior in rodents and humans. | track behavior, analyze and track behavior, rodent, human, automated analysis, imaging data, OpenBehavior |
is listed by: OpenBehavior is related to: DeepBehavior project |
DOI:10.3389/fnsys.2019.00020 | Free, Available for download, Freely Available | https://edspace.american.edu/openbehavior/project/deepbehavior/ | SCR_021414 | 2026-09-19 12:54:52 | 0 | ||||||||
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HC2: Human-Computer Confluence Resource Report Resource Website |
HC2: Human-Computer Confluence (RRID:SCR_005549) | HC2, HCC | knowledge environment, training resource | HC2 is an EU funded project that aims to promote, support and help define future lines of research in Human Computer Confluence (HCC). HCC is the study of the intersection of HCI, Cognitive Neuroscience, VR/AR, Presence, Pervasive Computing and how they can enable new forms of sensing, perception, interaction and understanding. In a sense it is the study of the disappearing interface. HCC, Human-Computer Confluence, is an ambitious research program studying how the emerging symbiotic relation between humans and computing devices can enable radically new forms of sensing, perception, interaction, and understanding. The horizontal character of HCC makes it a fascinating and fertile interdisciplinary field, but it can also compromise its growth, with researchers scattered across disciplines and groups worldwide. To address this we are building a community of HCC researchers. There are lots of ways you can join in. Add your name to the HCC Players Map, take advantage of our Exchange Program to work with colleagues at your favorite lab, sign up for our Summer School or just follow us on Twitter and LinkedIn to see what''s happening. In order to foster interdisciplinary research and promote HCC research we have set up an Exchange Program. Students that wish to apply for financial support from our Exchange Program should follow the steps provided. The Exchange Program is open to all graduate students (Masters and PhD). A maximum of 500 Euro support will be provided per student. | human, computing, cognitive neuroscience, summer school, funding resource | has parent organization: Starlab | European Union | nlx_144641 | SCR_005549 | Human-Computer Confluence, HC Squared, Human Computer Confluence | 2026-09-19 12:57:51 | 0 | |||||||
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NUgene Project Resource Report Resource Website 1+ mentions |
NUgene Project (RRID:SCR_007426) | NUgene | biomaterial supply resource, material resource | Collects and stores genetic (DNA) samples along with associated healthcare information from patients of Northwestern-affiliated hospitals and clinics. This resource is available to scientists to conduct groundbreaking genetic research. The information and blood samples provided will be used by researchers to examine the role genes play in the development and treatment of common diseases. The NUgene Project seeks to increase the understanding of genetic mechanisms underlying common diseases, assist in the development of DNA-based technology for diagnosis and treatment of disease, and aid physicians and other healthcare providers in the application of genetics to the practice of medicine. NUgene participants are recruited throughout the Northwestern-affiliated healthcare community in order to create an ethnically and medically diverse population for research. Participants must be 18 years of age or older and receive their medical care from a Northwestern-affiliated provider, regardless of health status. Consenting individuals complete all aspects of enrollment in a single meeting with a research coordinator. The enrollment process includes the donation of a single sample of blood and the completion of a self-administered questionnaire. Participants also sign a consent form during this encounter. The NUgene Project is an interdisciplinary project that relies on the expertise of individuals working in a variety of fields, including science, medicine, clinical research, statistics, epidemiology, and computational biology. NUgene''s multidisciplinary approach has spurred collaborations within Northwestern-affiliated institutions and with other outside institutions. This collaboration of ideas is the future of genetics and genomic research., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. | human, clinical, gene, gene bank, genetic, genomic, translational, medicine, genetic assessment, dna, genomic research, blood, self-administered questionnaire, questionnaire |
is listed by: One Mind Biospecimen Bank Listing is related to: DOAF is related to: Human Disease Ontology has parent organization: Northwestern University; Illinois; USA |
THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-00537 | SCR_007426 | 2026-09-19 12:57:54 | 6 | ||||||||
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I3-CRB: Interoperable IT Infrastructure for Biological Resources Centres / Biobanks - France Resource Report Resource Website |
I3-CRB: Interoperable IT Infrastructure for Biological Resources Centres / Biobanks - France (RRID:SCR_006991) | I3-CRB | biomaterial supply resource, material resource | Project to improve data and sample exchanges and to facilitate large scale analysis of data by improving interoperability of French Biological Resources Centres (BRC or biobanks) IT systems and biological databases. The work done in this project will be linked to other national (IBiSA, ANR, R��seau des Biobanques, Club 3C-R), European (BBMRI, ELIXIR) or international project (P3G). In the preliminary phase (2009-2010) I3-CRB has developed a directory of French Biological Resource Centres / Biobanks where one may register their French BRC or perform a search across all of them. Detail by overall data or kingdom is provided as well as many filtering options. Access to biological samples is provided by the participating BRC''''s. Biological Resources Centres (BRC or biobanks) collect annotated biological samples from various sources (human, animal, plant, bacteria...). The type of samples depends on the collection and the associated thematic (DNA, proteins, cells, tissues, blood, serum, organisms...). The aims of these centers are to collect, to store, to transform and to distribute the biological samples. They constitute a vital infrastructure for life science and health research. Goals of the French Biobanks/Biological Resource Centres: * List French biobanks and their biological collections * Improve sample exchanges * Improve the international visibility of the French biological collections MeSH terms have been integrated: Domains, diseases, and location of the disease (Anatomy). Collections/species are based on NCBI Taxonomy. | plant, animal, human, micro-organism, microorganism, bacteria, dna, protein, cell, tissue, blood, serum, organism, research |
is listed by: One Mind Biospecimen Bank Listing is related to: MeSH has parent organization: University of Lyon; France |
GIS IBiSA | Varying: Access to biological samples is provided by the participating BRC''''s., The community can contribute to this resource | nlx_36068 | SCR_006991 | Infrastructure Informatique Interop��rable pour les CRB | 2026-09-19 12:57:53 | 0 | ||||||
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NIMH Publications Resource Report Resource Website |
NIMH Publications (RRID:SCR_008846) | NIMH Publications | data or information resource, narrative resource | Publications put out by the National Institute of Mental Health. Publications are available by topic: Disorders: * Attention Deficit Hyperactivity Disorder (ADHD) * Anxiety Disorders * Autism * Bipolar Disorder * Borderline Personality Disorder * Depression * Eating Disorders * Generalized Anxiety Disorder * Obsessive-Compulsive Disorder (OCD) * Panic Disorder * Post-Traumatic Stress Disorder * Schizophrenia * Social Phobia Populations * Older Adults * Men''s Mental Health * Women''s Mental Health * Children and Adolescents Research * Basic Research * Clinical Research and Trials * Research Funding * Mental Health Services Research Other * Coping with Traumatic Events * Genetics * HIV/AIDS * Imaging * Medications * NIMH * Prevention * Statistics * Suicide Prevention * Treatments | spanish, mental health, mental disease, human, booklet, brochure, fact sheet | has parent organization: National Institute of Mental Health | NIMH | nlx_146238 | SCR_008846 | National Institute of Mental Health Publications | 2026-09-19 12:57:56 | 0 | |||||||
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ADMET Predictor Resource Report Resource Website 10+ mentions |
ADMET Predictor (RRID:SCR_014903) | software application, software resource | Software program for advanced predictive modeling of Absorption, Distribution, Metabolism, Elimination, and Toxicity (ADMET) properties of chemical substances in the human body. ADMET Predictor can estimate a number of vital ADMET properties (listed below) from molecular structures and build predictive models of new properties from user's data. | admet, absorption, distribution, metabolism, elminination, toxicity, chemical substances, human, prediction, model | Commercial | SCR_014903 | 2026-09-19 12:58:13 | 15 | |||||||||||
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4D Nucleome Resource Report Resource Website 10+ mentions |
4D Nucleome (RRID:SCR_016925) | data or information resource, portal, project portal | Research project to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect normal development and diseases. Portal provides free access to datasets, software packages, and protocols to advance biomedical research of nuclear architecture. Aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes. | nuclear, organization, gene, expression, cellular, function, normal, development, disease, map, structure, human, mouse, genome |
is listed by: NIDDK Information Network (dkNET) is related to: International Human Epigenome Consortium |
NIH Common Fund | PMID:28905911 | Public | SCR_016925 | 4D Nucleome Network; 4DN Web Portal, The 4D nucleome project, 4DN Portal | 2026-09-19 12:56:06 | 30 | |||||||
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mirDIP Resource Report Resource Website 100+ mentions |
mirDIP (RRID:SCR_016770) | data or information resource, database, portal | microRNA data integration portal to find microRNAs that target a gene, or genes targeted by a microRNA, in Homo sapiens. Software to integrate prediction databases to elucidate accurate microRNA:target relationships. Used for human microRNA prediction studies. | data, integral, portal, DIP, collect, predict, microRNA, gene, human | Canada Foundation for Innovation ; Canadian Cancer Society Research Institute ; Krembil Foundation ; Natural Sciences Research Council ; Ontario Research Fund |
PMID:29194489 | Free, Download available, Freely available, email address required to download, Acknowledgement requested | SCR_016770 | mirDIP 4.1, mirDIP, microRNA Data Integration Portal | 2026-09-19 12:56:06 | 229 | ||||||||
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brainlife.io Resource Report Resource Website 1+ mentions |
brainlife.io (RRID:SCR_016513) | data or information resource, portal | Platform for publishing reproducible code and datasets and providing access to national supercomputers, private clouds, and institutional high-performance computer systems to promote open software and data sharing to advance understanding of the human brain. | human, brain, life, data, application, technology, share, open, software, reproducible, code, dataset, |
has parent organization: Indiana University Bloomington; Indiana; USA works with: brainlife |
NSF BCS 1734853; NSF IIS 1636893 |
DOI:10.1038/s41597-019-0073-y | Public, Free, Freely available, Login required | https://github.com/brain-life | SCR_016513 | 2026-09-19 12:56:05 | 1 | |||||||
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AcceGen Biotech Resource Report Resource Website 1+ mentions |
AcceGen Biotech (RRID:SCR_017274) | biomaterial supply resource, cell repository, material resource | AcceGen offers most complete human and animal cell products and cell/molecular biology services for life science researchers worldwide. Cell line collections include primary cells, tumor cell lines, transfected stable cell lines, stem cells and immortalized cell lines. miRNA agomir/antagomir, nucleic acid kits, enzymes and custom cell/molecular biology services. | Company, AcceGen, human, animal, cell, cell lines, product, service, cell culture | SCR_017274 | 2026-09-19 12:56:07 | 3 | ||||||||||||
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ProteomeTools Resource Report Resource Website 10+ mentions |
ProteomeTools (RRID:SCR_018535) | data or information resource, portal, project portal | Project for building molecular and digital tools from human proteome to facilitate biomedical research, drug discovery, personalized medicine and life science research. | Molecular tool, human proteome, proteome, human, peptide, data |
is related to: ProteomicsDB is related to: ProteomeXchange |
Alexander von Humboldt Foundation ; American Recovery and Reinvestment Act ; European Research Council ; German Federal Ministry of Education and Research ; NCRR S10 RR027584; NHGRI RC2 HG005805; NIGMS P50 GM076547; NIGMS R01 GM087221; Swiss National Science Foundation |
PMID:28135259 | Free, Freely available | http://www.proteometools.org | SCR_018535 | 2026-09-19 12:56:10 | 23 | |||||||
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Vietnam Era Twin Registry Resource Report Resource Website 1+ mentions |
Vietnam Era Twin Registry (RRID:SCR_008807) | VET Registry | data or information resource, patient registry, people resource, portal, topical portal | The Vietnam Era Twin (VET) Registry is a closed cohort composed of approximately 7,000 middle-aged male-male twin pairs both of whom served in the military during the time of the Vietnam conflict (1964-1975). The Registry is a United States Department of Veterans Affairs (VA) resource that was originally constructed from military records; the Registry has been in existence for almost 20 years. It is one of the largest national twin registries in the US and currently has members living in all 50 states. Initially formed to address questions about the long-term health effects of service in Vietnam, the Registry has evolved into a resource for genetic epidemiological studies of mental and physical health conditions. Several waves of mail and telephone surveys have collected a wealth of health-related information on Registry twins, referred to as members. In addition to twins, selected adult offspring of twins and the mothers of those offspring are also VET Registry members. More recent data collection efforts have focused on specific sets of twin pairs and have conducted detailed clinical or laboratory testing. Selected Vietnam Era Registry Research Studies: * Veteran Health Study * VETSA 2: A Longitudinal Study of Cognitive Aging * Alcoholism Course thought Midlife: A Twin Family Study and Offspring of Twins: G, E and GxE Risk for Alcoholism * GE: Offspring of Twins with Substance Use Disorder * Mechanisms Linking Depression to Cardiovascular Risk (Twins Heart Study 2) * Post-traumatic Stress Disorder and Cardiovascular Disease * Biological Markers for Post-traumatic Stress Disorder (T3) * Memory and the Hippocampus in Vietnam-era Twins with PTSD (Time 3) | twin, male, adult, gene, genetic, post-traumatic stress disorder, cardiovascular disease, child, mother, human, substance-related disorder, depressive disorder, memory, hippocampus, mental health, physical health, epidemiology |
has parent organization: U.S. Department of Veterans Affairs is parent organization of: Vietnam Era Twin Registry Biospecimen Repository |
Aging | nlx_144388 | SCR_008807 | 2026-09-19 12:55:27 | 2 | ||||||||
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Center for Comparative Medicine and Translational Research Resource Report Resource Website |
Center for Comparative Medicine and Translational Research (RRID:SCR_008299) | CCMTR | data or information resource, department portal, organization portal, portal | The mission of the CCMTR is to promote scientific discovery and facilitate its clinical application to achieve the goal of improving the health of animals and humans. The needs of the patients direct the emphasis of basic research, patient samples provide the critical resource to investigate the basis of disease, and patient participation in clinical studies is required to generate the evidence needed to apply new drugs, vaccines and technology to the broader patient population. Initiatives at the Center are designed to develop the multidisciplinary teams necessary to bring an idea from the lab to the patient. The Center is home to service cores that provide advanced technology, collect and store clinical patient samples, and perform clinical trials to validate new medical interventions. North Carolina State University''s College of Veterinary Medicine (CVM) is a dynamic community whose members are dedicated to preparing veterinarians and veterinarian scientists while advancing animal and human health from the cellular level through entire ecosystems. | drug, ecosystem, clinical, discovery, disease, health, human, patient, research, scientific, technology, vaccine, veterinary | has parent organization: North Carolina State University; North Carolina; USA | nif-0000-24380 | http://cvm.ncsu.edu/ccmtr/index.htm | SCR_008299 | 2026-09-19 12:55:31 | 0 | ||||||||
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Candidate Genes to Inherited Diseases Resource Report Resource Website 1+ mentions |
Candidate Genes to Inherited Diseases (RRID:SCR_008190) | G2D | analysis service resource, data analysis service, data or information resource, database, production service resource, service resource | THIS RESOURCE IS NO LONGER IN SERVICE, documented August 22, 2016. A database of candidate genes for mapped inherited human diseases. Candidate priorities are automatically established by a data mining algorithm that extracts putative genes in the chromosomal region where the disease is mapped, and evaluates their possible relation to the disease based on the phenotype of the disorder. Data analysis uses a scoring system developed for the possible functional relations of human genes to genetically inherited diseases that have been mapped onto chromosomal regions without assignment of a particular gene. Methodology can be divided in two parts: the association of genes to phenotypic features, and the identification of candidate genes on a chromosonal region by homology. This is an analysis of relations between phenotypic features and chemical objects, and from chemical objects to protein function terms, based on the whole MEDLINE and RefSeq databases. | function, gene, genetic, chromosome, disease, disorder, genome, homology, human, phenotype, protein, region, candidate gene, database, data warehouse, data set, bio.tools |
is listed by: 3DVC is listed by: Gene Ontology Tools is listed by: Debian is listed by: bio.tools is related to: Gene Ontology has parent organization: European Molecular Biology Laboratory has parent organization: EMBL - Bork Group |
PMID:16115313 | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-21162, biotools:g2d | http://www.bork.embl-heidelberg.de/g2d/, http://www.ogic.ca/projects/g2d_2/, https://bio.tools/g2d | SCR_008190 | G2D - Candidate Genes to Inherited Diseases, Genes2Diseases | 2026-09-19 12:55:10 | 2 | |||||
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NEIBank Resource Report Resource Website 10+ mentions |
NEIBank (RRID:SCR_007294) | NEIBank | analysis service resource, data analysis service, data or information resource, database, production service resource, service resource | An integrated resource for genomics and bioinformatics in vision research including expressed sequence tag (EST) data and sequence-verified cDNA clones for multiple eye tissues of several species, web-based access to human eye-specific SAGE data through EyeSAGE, and comprehensive, annotated databases of known human eye disease genes and candidate disease gene loci. All expression- and disease-related data are integrated in EyeBrowse, an eye-centric genome browser. NEIBank provides a comprehensive overview of current knowledge of the transcriptional repertoires of eye tissues and their relation to pathology. The data can be interrogated in several ways. Specific gene names can be entered into the search window. Alternatively, regions of the genome can be displayed. For example, entering two STS markers separated by a semicolon (e.g. RH18061;RH80175) allows the display of the entire chromosomal region associated with the mapping of a specific disease locus. ESTs for each tissue can then be displayed to help in the selection of candidate genes. In addition, sequences can be entered into a BLAST search and rapidly aligned on the genome, again showing eye derived ESTs for the same region. To see the same region at the full UCSC site, cut and paste the location from the position window of the genome browser. EyeBrowse includes a custom track display SAGE data for human eye tissues derived from the EyeSAGE project. The track shows the normalized sum of SAGE tag counts from all published eye-related SAGE datasets centered on the position of each identifiable Unigene cluster. This indicates relative activity of each gene locus in eye. Clicking on the vertical count bar for a particular location will bring up a display listing gene details and linking to specific SAGE counts for each eye SAGE library and comparisons with normalized sums for neural and non-neural tissues. To view or alter settings for the EyeSAGE track on EyeBrowse, click on the vertical gray bar at the left of the display. Other custom tracks display known eye disease genes and mapped intervals for candidate loci for retinal disease, cataract, myopia and cornea disease. These link back to further information at NEIBank. | ear, taste, genetics, cdna, chicken, ciliary body, cornea, fovea, dog, guinea pig, human, iris, lacrimal gland, lens, mouse, ocular surface system, optic nerve, rabbit, rat, retina, rpe, choroid, sequence data, trabecular meshwork, whole eye, zebrafish, library, vision, eye, gene, library, disease, loci, ocular genomics, cdna library, expressed sequence tag, blast, cataract, cornea, glaucoma, myopia, retinal disease, genomics, eye tracking device | has parent organization: National Eye Institute (NEI) Commons | Eye disease, Cataract, Glaucoma, Myopia, Retinal disease | NIH Blueprint for Neuroscience Research ; NEI R01 EY13315; NEI R01 EY11286; NEI P30EY0054722 |
PMID:18648525 | nif-0000-00097 | SCR_007294 | NEI Bank | 2026-09-19 12:55:10 | 15 | |||||
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Human Islet Research Network (HIRN) Resource Report Resource Website 100+ mentions |
Human Islet Research Network (HIRN) (RRID:SCR_014393) | HIRN | data or information resource, disease-related portal, portal, topical portal | Network helps to organize and support collaborative research related to loss of functional beta cell mass in Type 1 Diabetes (T1D). Project consists of four independent research initiatives: Consortium on Beta Cell Death and Survival (CBDS), Consortium on Human Islet Biomimetics (CHIB), Consortium on Modeling Autoimmune Interactions (CMAI), Consortium on Targeting and Regeneration (CTAR), and Human Pancreas Analysis Program (HPAP). | islet, human, consortia, functional loss, beta cell, research network, funding resource |
is used by: Hypothesis Center is listed by: NIDDK Information Network (dkNET) is related to: Pancreatlas is related to: scPancMeta App is related to: PANC-DB has organization facet: HIRN Consortium on Beta Cell Death and Survival has organization facet: HIRN Consortium on Human Islet Biomimetics has organization facet: HIRN Consortium on Modeling Autoimmune Interactions has organization facet: HIRN Consortium on Targeting and Regeneration has organization facet: HIRN Human Pancreas Analysis Program has organization facet: HIRN Bioinformatics Center has organization facet: HIRN Coordinating Center has organization facet: HIRN Human Pancreas Analysis Consortium |
Type 1 diabetes, Diabetes | NIDDK | SCR_014393 | Human Islet Research Network | 2026-09-19 12:55:14 | 247 | |||||||
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COnsensus-DEgenerate Hybride Oligonucleotide Primers Resource Report Resource Website 1+ mentions |
COnsensus-DEgenerate Hybride Oligonucleotide Primers (RRID:SCR_002875) | analysis service resource, data analysis service, data analysis software, data processing software, production service resource, service resource, software application, software resource | This COnsensus-DEgenerate Hybrid Oligonucleotide Primer (CODEHOP) strategy has been implemented as a computer program that is accessible over the World-Wide Web and is directly linked from the BlockMaker multiple sequence alignment site for hybrid primer prediction beginning with a set of related protein sequences. This is a new primer design strategy for PCR amplification of unknown targets that are related to multiply-aligned protein sequences. Each primer consists of a short 3' degenerate core region and a longer 5' consensus clamp region. Only 3-4 highly conserved amino acid residues are necessary for design of the core, which is stabilized by the clamp during annealing to template molecules. During later rounds of amplification, the non-degenerate clamp permits stable annealing to product molecules. The researchers demonstrate the practical utility of this hybrid primer method by detection of diverse reverse transcriptase-like genes in a human genome, and by detection of C5 DNA methyltransferase homologs in various plant DNAs. In each case, amplified products were sufficiently pure to be cloned without gel fractionation. Sponsors: This work was supported in part by a grant from the M. J. Murdock Charitable Trust and by a grant from NIH. S. P. is a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 15,2026. | fractionation, gel, 3', amplification, clone, dna, genome, homolog, human, hybrid, molecule, oligonucleotide, pcr, plant, primer, protein, sequence, transcriptase-methyltransferase |
is related to: OMICtools has parent organization: University of Washington; Seattle; USA |
THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-25557 | SCR_002875 | CODEHOP | 2026-09-19 12:55:05 | 8 | ||||||||
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Metscape Resource Report Resource Website 100+ mentions |
Metscape (RRID:SCR_014687) | resource, software resource, source code | A software program that allows users to visualize and interpret human metabolim and expression profiling data by providing users with a bioinformatics framework. Its features include bulding and analyzing networks of genes and compounds, identifying enriched pathways from expression profiling data, and visualizing changes in metabolite data. | metabolomics, metabolomics tool, visualization, expression profiling, gene, compound, metabolism, human |
is listed by: Metabolomics Workbench is listed by: SoftCite |
NIDDK U24 DK097153; NIDDK P30DK089503 |
PMID:22135418 | Freely available | SCR_014687 | 2026-09-19 12:55:48 | 154 |
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